Myeloid differentiation primary response protein MyD88 (MYD88) is a 296-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q99836.
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The mean pLDDT of this model is 80.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 15% |
| 70 to 90 | Confident: backbone generally right | 69% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575, PubMed:33718825, PubMed:37971847). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:19506249, PubMed:24316379, PubMed:40638072). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses…
Homodimer. Also forms heterodimers with TIRAP (PubMed:17322885, PubMed:19506249, PubMed:19948740). Binds to TLR2, TLR5, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII.…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4EO7 | X-ray | 1.45 Å | A=157-296 |
| 9HFV | X-ray | 1.45 Å | B=127-146 |
| 4DOM | X-ray | 1.8 Å | A=157-296 |
| 9HGH | X-ray | 1.9 Å | B=125-141 |
| 7BER | X-ray | 2.3 Å | A=155-296 |
| 7L6W | X-ray | 2.3 Å | A=159-296 |
| 8S78 | EM | 2.85 Å | A=154-296 |
| 7BEQ | EM | 3.0 Å | A=155-296 |
| 6I3N | EM | 3.1 Å | A/B/C/D/E/F/G/H/I/J/K/L/M=1-151 |
| 8W8M | EM | 3.28 Å | 1A/1B/1C/1D/1E/1F/2A/2B/2C/2D/2E/2F/3A/3B/3C/3D/3E/3F/A1/A2/A3/B1/B2/B3/C1/C2/C3/D1/D2/D3=153-296 |
| 8YYM | EM | 3.3 Å | A/AA/AB/AC/B/BA/BB/BC/C/CA/CB/CC/D/DA/DB/DC/E/EA/EB/EC/F/FA/FB/FC/G/GA/GB/GC/H/HA=153-296 |
| 3MOP | X-ray | 3.4 Å | A/B/C/D/E/F=20-117 |
| 2JS7 | NMR | A=146-296 | |
| 2Z5V | NMR | A=148-296 |
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