Probable ATP-dependent RNA helicase DDX23 (DDX23) is a 820-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BUQ8.
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The mean pLDDT of this model is 77.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 33% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779)
The phosphorylated form (by SRPK2) is a component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39 (PubMed:16723661, PubMed:9409622). Identified in the spliceosome C complex (PubMed:11991638). Interacts with ERBB4 (PubMed:20858735).…
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4NHO | X-ray | 2.0 Å | A=338-820 |
| 6QW6 | EM | 2.92 Å | 5X=1-820 |
| 8Q91 | EM | 3.1 Å | D=1-820 |
| 8QOZ | EM | 3.1 Å | G=1-820 |
| 8H6E | EM | 3.2 Å | 4U=1-820 |
| 8RC0 | EM | 3.2 Å | D=1-820 |
| 8H6J | EM | 3.25 Å | 4U=1-820 |
| 6QX9 | EM | 3.28 Å | 5X=1-820 |
| 8Y6O | EM | 3.38 Å | I=1-820 |
| 8QP8 | EM | 3.5 Å | G=1-820 |
| 8QPA | EM | 3.7 Å | G=1-820 |
| 8QPB | EM | 3.7 Å | G=1-820 |
| 8Q7W | EM | 3.9 Å | E=1-820 |
| 8QP9 | EM | 4.1 Å | G=1-820 |
| 8QPK | EM | 4.2 Å | G=1-820 |
| 8R09 | EM | 4.3 Å | G=1-820 |
| 8R0B | EM | 4.4 Å | G=1-820 |
| 8Q7X | EM | 4.6 Å | E=1-820 |
| 6AH0 | EM | 5.7 Å | X=1-820 |
| 8R0A | EM | 5.8 Å | G=1-820 |
Showing 20 of 24 experimental structures (best resolution first).
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