Sorbin and SH3 domain-containing protein 1 (SORBS1) is a 1292-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9BX66.
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The mean pLDDT of this model is 46.9 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 10% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 74% |
What pLDDT means and how to read it
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity)
Interacts (via third SH3 domain) with the Ten-1 ICD form of TENM1; the interaction induces the translocation of SORBS1 to the nucleus. Interacts with INSM1 (By similarity). Interacts with the long isoform of AFDN and with VCL. AFDN and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex. Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain.…
Cell junction, adherens junction, Cell membrane, Cytoplasm, cytoskeleton, Cell junction, focal adhesion, Nucleus, Nucleus matrix
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2O9S | X-ray | 0.83 Å | A=870-930 |
| 4LN2 | X-ray | 1.0 Å | A=866-930 |
| 4LNP | X-ray | 1.41 Å | A=794-854 |
| 2O31 | X-ray | 1.5 Å | A=870-930 |
| 2O9V | X-ray | 1.63 Å | A=870-930 |
| 2O2W | X-ray | 2.27 Å | A=870-930 |
| 2DL3 | NMR | A=796-850 | |
| 2ECZ | NMR | A=870-926 | |
| 2LJ0 | NMR | A=1228-1292 | |
| 2LJ1 | NMR | A=1228-1291 | |
| 2MOX | NMR | A=791-930 |
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