Microtubule-associated protein 1 light chain 3 alpha (MAP1LC3A) is a 121-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9H492.
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The mean pLDDT of this model is 91.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 78% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538)
3 different light chains, LC1 (a cleavage product of MAP1B), LC2 (a cleavage product of MAP1A) and LC3 (produced by one of the MAP1LC3 genes), can associate with the MAP1A or MAP1B heavy chains (By similarity). Interacts with TP53INP1 and TP53INP2 (PubMed:19056683, PubMed:22470510). Directly interacts with SQSTM1; this interaction leads to MAP1LC3A recruitment to inclusion bodies containing…
Cytoplasmic vesicle, autophagosome membrane, Endomembrane system, Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7RA0 | X-ray | 1.36 Å | A=1-120 |
| 6TBE | X-ray | 1.67 Å | A=4-119 |
| 7R9Z | X-ray | 1.72 Å | A=1-120 |
| 7R9W | X-ray | 1.75 Å | A=1-120 |
| 3WAN | X-ray | 1.77 Å | A/B=2-121 |
| 4ZDV | X-ray | 1.8 Å | A=2-120 |
| 8T36 | X-ray | 1.85 Å | A=1-121 |
| 8T35 | X-ray | 1.9 Å | A/B=1-121 |
| 3WAL | X-ray | 2.0 Å | A=2-121 |
| 8T2L | X-ray | 2.24 Å | A/B=1-121 |
| 5CX3 | X-ray | 2.3 Å | A/B/C/D=1-121 |
| 8T4T | X-ray | 2.36 Å | A/B=1-121 |
| 5DPR | X-ray | 2.5 Å | A/B/C/D=3-121 |
| 3ECI | X-ray | 2.65 Å | A/B=1-121 |
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