Pre-mRNA-splicing factor SYF1 (XAB2) is a 855-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9HCS7.
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The mean pLDDT of this model is 73.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 1% |
| 70 to 90 | Confident: backbone generally right | 75% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing (PubMed:10944529, PubMed:17981804)
Associates with RNA polymerase II, the TCR-specific proteins CKN1/CSA and ERCC6/CSB, and XPA (PubMed:10944529). Identified in the spliceosome C complex (PubMed:11991638, PubMed:28076346, PubMed:28502770). Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE (PubMed:17981804). Identified in a pentameric intron-binding (IB) complex…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8C6J | EM | 2.8 Å | T=1-855 |
| 6ID1 | EM | 2.86 Å | I=1-855 |
| 6ID0 | EM | 2.9 Å | I=1-855 |
| 6ICZ | EM | 3.0 Å | I=1-855 |
| 8I0R | EM | 3.0 Å | I=1-855 |
| 8I0T | EM | 3.0 Å | I=1-855 |
| 8I0V | EM | 3.0 Å | I=1-855 |
| 6QDV | EM | 3.3 Å | T=1-855 |
| 8I0U | EM | 3.3 Å | I=1-855 |
| 9FMD | EM | 3.3 Å | I=1-855 |
| 8I0P | EM | 3.4 Å | I=1-855 |
| 8I0W | EM | 3.4 Å | I=1-855 |
| 8RO2 | EM | 3.5 Å | I=1-855 |
| 5XJC | EM | 3.6 Å | I=1-855 |
| 7W59 | EM | 3.6 Å | I=1-855 |
| 7W5A | EM | 3.6 Å | I=1-855 |
| 5YZG | EM | 4.1 Å | I=1-855 |
| 8I0S | EM | 4.2 Å | I=1-855 |
| 7W5B | EM | 4.3 Å | I=1-855 |
| 6FF7 | EM | 4.5 Å | M=1-855 |
Showing 20 of 26 experimental structures (best resolution first).
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