Spliceosome-associated protein CWC15 homolog (CWC15) is a 229-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9P013.
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The mean pLDDT of this model is 74.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 33% |
| 50 to 70 | Low: treat with caution | 24% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)
Identified in the spliceosome C complex (PubMed:28076346, PubMed:28502770). Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8 (PubMed:20176811). Interacts directly with CTNNBL1 in the complex (PubMed:20176811). Component of the minor…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8C6J | EM | 2.8 Å | P=1-229 |
| 6ID1 | EM | 2.86 Å | P=1-229 |
| 7DVQ | EM | 2.89 Å | P=1-229 |
| 6ID0 | EM | 2.9 Å | P=1-229 |
| 6ICZ | EM | 3.0 Å | P=1-229 |
| 8I0R | EM | 3.0 Å | P=1-229 |
| 8I0T | EM | 3.0 Å | P=1-229 |
| 8I0V | EM | 3.0 Å | P=1-229 |
| 7QTT | EM | 3.1 Å | Q=1-229 |
| 6QDV | EM | 3.3 Å | P=1-229 |
| 8I0U | EM | 3.3 Å | P=1-229 |
| 9FMD | EM | 3.3 Å | P=1-229 |
| 6ZYM | EM | 3.4 Å | R=1-229 |
| 8I0P | EM | 3.4 Å | P=1-229 |
| 8I0W | EM | 3.4 Å | P=1-229 |
| 8RO2 | EM | 3.5 Å | P=1-229 |
| 5XJC | EM | 3.6 Å | P=1-229 |
| 7W59 | EM | 3.6 Å | P=1-229 |
| 7W5A | EM | 3.6 Å | P=1-229 |
| 7ABF | EM | 3.9 Å | R=1-229 |
Showing 20 of 33 experimental structures (best resolution first).
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