Death domain-associated protein 6 (DAXX) is a 740-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9UER7.
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The mean pLDDT of this model is 62.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 57% |
What pLDDT means and how to read it
Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a…
Homomultimer. Interacts (via C-terminus) with TNFRSF6 (via death domain). Interacts with PAX5, SLC2A4/GLUT4, MAP3K5, TGFBR2, phosphorylated dimeric HSPB1/HSP27, CENPC, ETS1, sumoylated PML, UBE2I, MCRS1 and TP53. Interacts (via N-terminus) with HIPK2 and HIPK3. Interacts with HIPK1, which induces translocation from PML/POD/ND10 nuclear bodies to chromatin and enhances association with HDAC1.…
Cytoplasm, Nucleus, nucleoplasm, Nucleus, PML body, Nucleus, nucleolus, Chromosome, centromere, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5GRQ | X-ray | 1.58 Å | A/B=55-144 |
| 4H9N | X-ray | 1.95 Å | C=178-389 |
| 4H9Q | X-ray | 1.95 Å | C=178-389 |
| 4H9O | X-ray | 2.05 Å | C=178-389 |
| 4H9P | X-ray | 2.2 Å | C=178-389 |
| 4H9R | X-ray | 2.2 Å | C=178-389 |
| 5Y18 | X-ray | 2.2 Å | A=55-144 |
| 4H9S | X-ray | 2.6 Å | E/F=183-398 |
| 4HGA | X-ray | 2.8 Å | A=184-390 |
| 5Y6O | X-ray | 3.1 Å | A/B/C/D/E/F/G/H/I=50-144 |
| 5KDM | X-ray | 3.5 Å | C=178-389 |
| 2KQS | NMR | B=721-740 | |
| 2KZS | NMR | A=55-144 | |
| 2KZU | NMR | A=55-144 |
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