F-box/WD repeat-containing protein 1A (BTRC) is a 605-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Y297.
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The mean pLDDT of this model is 79.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 63% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:22087322, PubMed:25503564, PubMed:25704143, PubMed:36608670, PubMed:9859996, PubMed:9990852). Recognizes and binds to phosphorylated target proteins (PubMed:10066435,…
Homodimer. Self-associates. Component of the SCF(BTRC) complex formed of CUL1, SKP1, RBX1 and a BTRC dimer (PubMed:10066435, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:36608670, PubMed:9990852). Direct interaction with SKP1 occurs via the F-box domain. Interacts with phosphorylated ubiquitination substrates SMAD3 and SMAD4. Interacts with phosphorylated ubiquitination substrates…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9T9W | X-ray | 1.16 Å | A=222-584 |
| 9TES | X-ray | 1.22 Å | A=222-584 |
| 9TDZ | X-ray | 1.35 Å | A=222-584 |
| 9TG7 | X-ray | 1.68 Å | A=222-584 |
| 9T8Y | X-ray | 1.79 Å | A=222-584 |
| 9TFU | X-ray | 2.0 Å | A=222-584 |
| 6M90 | X-ray | 2.05 Å | A=175-605 |
| 9T95 | X-ray | 2.15 Å | A=222-584 |
| 6M92 | X-ray | 2.35 Å | A=175-605 |
| 6M91 | X-ray | 2.4 Å | A=175-605 |
| 2P64 | X-ray | 2.5 Å | A/B=128-177 |
| 6M93 | X-ray | 2.5 Å | A=175-605 |
| 6M94 | X-ray | 2.7 Å | A=175-605 |
| 1P22 | X-ray | 2.95 Å | A=175-605 |
| 6TTU | EM | 3.7 Å | T=1-605 |
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