Partitioning defective 3 homolog (Pard3) is a 1337-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q9Z340.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 54.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 15% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 61% |
What pLDDT means and how to read it
Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:18550519). Seems to play a central role in the formation of epithelial tight junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination (PubMed:21949390). Targets the phosphatase PTEN to cell junctions…
Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3. Interacts (via PDZ 1 domain) with PARD6A, PARD6B and F11R/JAM1. Interacts with AURKA, AURKB and SIRT2 (By similarity). Interacts with PRKCI. Interacts with PRKCZ (Probable). Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. Interacts with LIMK2 and CDH5. Component of the Par…
Cytoplasm, Endomembrane system, Cell junction, Cell junction, tight junction, Cell junction, adherens junction, Cytoplasm, cell cortex, Cytoplasm, cytoskeleton, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6JUE | X-ray | 1.55 Å | L=582-685 |
| 4DC2 | X-ray | 2.4 Å | Z=813-840 |
| 9IMP | X-ray | 2.87 Å | A/B/C/D/E/F=580-685 |
| 4I6P | X-ray | 2.9 Å | A/B=2-83 |
| 3ZEE | EM | 6.1 Å | A=2-82 |
| 2K1Z | NMR | A=582-685 | |
| 2K20 | NMR | A=582-685 | |
| 2NS5 | NMR | A=2-83 | |
| 2OGP | NMR | A=454-550 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.