10NL: Xenopus KCNQ1

Xenopus KCNQ1 in complex with UCL2077. Determined by electron microscopy at 3.81 Å resolution. Released 2 Sept 2026.

Method
Electron microscopy
Resolution
3.81 Å
Organisms
Homo sapiens, Xenopus laevis
Chains
8
Atoms
14,832
Mol. weight
317.61 kDa
Ligands
A1C6W
Released
2 Sept 2026

Explore 10NL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

10NL contains 120 α-helices and 20 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and H: 8 helices, 4 β-strands

ElementResiduesLengthSheet
α-helix11-2111
β-strand2816
α-helix30-4011
α-helix46-5510
β-strand6416
α-helix66-749
α-helix80-9314
β-strand100-10237
α-helix103-11210
α-helix119-12810
β-strand136-13837
α-helix140-1456
Chains B and M: 8 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix11-2111
β-strand2818
α-helix30-4011
α-helix46-5510
β-strand6418
α-helix66-749
α-helix80-9314
β-strand100-10239
α-helix103-1119
α-helix119-12810
β-strand136-13839
α-helix140-1456
Chains C and E: 22 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix96-1049
α-helix110-13324
α-helix136-1383
α-helix141-1455
α-helix146-16722
α-helix168-1703
α-helix172-1743
α-helix176-1849
α-helix187-20317
α-helix217-22812
α-helix229-2313
α-helix236-24712
α-helix251-27323
β-strand27815
β-strand28415
α-helix289-30012
α-helix313-32816
α-helix332-35019
α-helix351-3533
α-helix357-37216
α-helix373-3753
α-helix380-3823
α-helix499-52123
α-helix527-54923
Chains D and G: 22 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix96-10510
α-helix110-13223
α-helix136-1383
α-helix139-16729
α-helix168-1703
α-helix172-1743
α-helix176-1838
α-helix188-20013
α-helix201-2044
α-helix217-2204
α-helix221-2277
α-helix228-2303
α-helix236-24712
α-helix249-27426
α-helix277-2793
α-helix289-30012
α-helix313-32513
α-helix328-35023
α-helix357-37317
α-helix380-3823
α-helix498-52124
α-helix527-55024

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Calmodulin-1A, B, H, Mprotein149Homo sapiensP0DP23 (AlphaFold model)
Potassium voltage-gated channel subfamily KQT member 1C, D, E, Gprotein545Xenopus laevisP70057 (AlphaFold model)
Sequence of entity 1 (A, B, H, M), FASTA
>10NL_1 Calmodulin-1 (chains A, B, H, M)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK
Sequence of entity 2 (C, D, E, G), FASTA
>10NL_2 Potassium voltage-gated channel subfamily KQT member 1 (chains C, D, E, G)
MATDPPRPTINLDPRVSIYSGRRPLLSRTNIQGRVYNFLERPTGWKCFVYHFTVFLIVLI
CLIFSVLSTIQQYNNLATETLFWMEIVLVVFFGAEYVVRLWSAGCRSKYVGVWGRLRFAR
KPISVIDLIVVVASVIVLCVGSNGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVV
FIHRQELITTLYIGFLGLIFSSYFVYLAEKDAIDSSGEYQFGSYADALWWGVVTVTTIGY
GDKVPQTWIGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLI
QTAWRCYAAENPDSATWKIYIRKQSRNHHLMSPSPKPKKSAMVKKKKIRTERDEGSTDKM
LNIPHITYDHVADDRKNDGYSVESYENTVRKPFGFLDPSTGPFIRTSSFTDDLDMEGDTL
LTPITHISELKEHHRAAIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRI
KELQRRLDQSLGKPSLFLSVSDKVKDKGINTIGSRLNRVEDKVTQMDHKLNLITDMLHHL
LTNQQ

Ligands and cofactors

IDNameFormulaCopies
A1C6W1,1,1-triphenyl-N-[(pyridin-3-yl)methyl]methanamineC25 H22 N22

Primary citation

Structural and kinetic mechanisms of state-dependent potassium channel inhibition. Kyriakis, E., Roscioni, A., Eldstrom, J. et al. Sci Adv (2026).

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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