1C5G: Plasminogen activator inhibitor-1

Plasminogen activator inhibitor-1. Determined by X-ray diffraction at 2.6 Å resolution. Released 17 Dec 1999.

Method: X-ray diffraction
Resolution: 2.6 Å
Organism: Homo sapiens
Chains: 1
Atoms: 3,013
Mol. weight: 45.11 kDa
Released: 17 Dec 1999

Explore 1C5G in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1C5G contains 14 α-helices and 18 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 14 helices, 18 β-strands

Element	Residues	Length	Sheet
α-helix	27-48	22
β-strand	53	1	1
β-strand	56-57	2	2
α-helix	59-68	10
α-helix	75-85	11
α-helix	94-105	12
α-helix	108-110	3
β-strand	113-123	11	3
α-helix	128-129	2
α-helix	132-140	9
β-strand	145-147	3	3
α-helix	152-166	15
α-helix	177-179	3
β-strand	186-197	12	3
β-strand	198	1	4
α-helix	201-203	3
β-strand	208-211	4	2
β-strand	221-238	18	2
β-strand	242-250	9	2
β-strand	251	1	4
β-strand	256-263	8	2
α-helix	271-274	4
α-helix	279-286	8
β-strand	290-299	10	2
β-strand	301-308	8	3
α-helix	310-316	7
α-helix	320-322	3
β-strand	340-351	12	3
β-strand	355-366	12	3
β-strand	377	1	1
β-strand	380-387	8	2
β-strand	392-400	9	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Plasminogen activator inhibitor-1	A	protein	402	Homo sapiens	P05121 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1C5G_1 PLASMINOGEN ACTIVATOR INHIBITOR-1 (chains A)
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP

Primary citation

Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition. Tucker, H.M., Mottonen, J., Goldsmith, E.J. et al. Nat Struct Biol (1995) 2:442-445. DOI 10.1038/nsb0695-442 · PubMed

Other PDB entries of the same protein (UniProt P05121 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7AQF 1.77 Å, Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active…
1LJ5 1.8 Å, 1.8A Resolution Structure of Latent Plasminogen Activator Inhibitor-1(PAI-1)
6ZRV 1.88 Å, Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F)…
1A7C 1.95 Å, Human plasminogen activator inhibitor type-1 in complex with a pentapeptide
3CVM 2.02 Å, High resolution structure of a stable Plasminogen activator inhibitor type-1 in its…
6GWN 2.03 Å, Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F)…
1DVN 2.1 Å, Latent form of plasminogen activator inhibitor-1 (pai-1)
4G8R 2.19 Å, Crystal Structure of a novel small molecule inactivator bound to plasminogen activator…
7AQG 2.27 Å, Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active…
1OC0 2.28 Å, plasminogen activator inhibitor-1 complex with somatomedin B domain of vitronectin
6GWP 2.28 Å, Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in…
3PB1 2.3 Å, Crystal Structure of a Michaelis Complex between Plasminogen Activator Inhibitor-1 and…

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