1DVN: Latent form of plasminogen activator inhibitor-1

Latent form of plasminogen activator inhibitor-1 (pai-1). Determined by X-ray diffraction at 2.1 Å resolution. Released 13 Sept 2000.

Method: X-ray diffraction
Resolution: 2.1 Å
Organism: Homo sapiens
Chains: 1
Atoms: 3,326
Mol. weight: 42.82 kDa
Released: 13 Sept 2000

Explore 1DVN in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1DVN contains 13 α-helices and 19 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 13 helices, 19 β-strands

Element	Residues	Length	Sheet
α-helix	4-26	23
β-strand	30	1	1
β-strand	32-34	3	2
α-helix	36-49	14
α-helix	52-62	11
α-helix	71-83	13
α-helix	85-87	3
β-strand	90-100	11	3
α-helix	105-106	2
α-helix	109-117	9
β-strand	122-124	3	3
α-helix	129-143	15
β-strand	163-174	12	3
β-strand	175	1	4
α-helix	178-181	4
β-strand	186-190	5	5
β-strand	196-200	5	5
β-strand	201-214	14	2
β-strand	220-227	8	2
β-strand	228	1	4
β-strand	233-240	8	2
α-helix	248-251	4
α-helix	256-264	9
β-strand	267-276	10	2
β-strand	278-285	8	3
α-helix	287-292	6
α-helix	297-299	3
β-strand	319-328	10	3
β-strand	332-343	12	3
β-strand	354	1	1
β-strand	357-364	8	2
β-strand	369-377	9	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Plasminogen activator inhibitor-1	A	protein	379	Homo sapiens	P05121 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1DVN_1 PLASMINOGEN ACTIVATOR INHIBITOR-1 (chains A)
VHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQA
AMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRST
VKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFP
DSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAP
YEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFR
QFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLF
VVRHNPTGTVLFMGQVMEP

Primary citation

Structures of active and latent PAI-1: a possible stabilizing role for chloride ions. Stout, T.J., Graham, H., Buckley, D.I. et al. Biochemistry (2000) 39:8460-8469. DOI 10.1021/bi000290w · PubMed

Other PDB entries of the same protein (UniProt P05121 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7AQF 1.77 Å, Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active…
1LJ5 1.8 Å, 1.8A Resolution Structure of Latent Plasminogen Activator Inhibitor-1(PAI-1)
6ZRV 1.88 Å, Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F)…
1A7C 1.95 Å, Human plasminogen activator inhibitor type-1 in complex with a pentapeptide
3CVM 2.02 Å, High resolution structure of a stable Plasminogen activator inhibitor type-1 in its…
6GWN 2.03 Å, Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F)…
4G8R 2.19 Å, Crystal Structure of a novel small molecule inactivator bound to plasminogen activator…
7AQG 2.27 Å, Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active…
1OC0 2.28 Å, plasminogen activator inhibitor-1 complex with somatomedin B domain of vitronectin
6GWP 2.28 Å, Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in…
3PB1 2.3 Å, Crystal Structure of a Michaelis Complex between Plasminogen Activator Inhibitor-1 and…
3Q02 2.3 Å, Crystal structure of plasminogen activator inhibitor-1 in a metastable active…

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