Plasminogen activator inhibitor 1 (SERPINE1) is a 402-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P05121.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 88.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 80% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:17912461, PubMed:8481516, PubMed:9207454, PubMed:21925150). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair…
Forms a heterodimer with TMPRSS7 (PubMed:15853774). Interacts with VTN (PubMed:7522053). Binds LRP1B; binding is followed by internalization and degradation (PubMed:11384978). Interacts with PPP1CB (PubMed:28296156). In complex with PLAU/uPA, interacts with PLAUR/uPAR (PubMed:15053742). Interacts with SORL1 and LRP1, either alone or in complex with PLAU; these interactions are abolished in the…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7AQF | X-ray | 1.77 Å | A/B=24-402 |
| 1LJ5 | X-ray | 1.8 Å | A=24-402 |
| 6ZRV | X-ray | 1.88 Å | A=24-402 |
| 1A7C | X-ray | 1.95 Å | A=24-402 |
| 3CVM | X-ray | 2.02 Å | A/B=21-402 |
| 6GWN | X-ray | 2.03 Å | A=24-402 |
| 1DVN | X-ray | 2.1 Å | A=24-402 |
| 4G8R | X-ray | 2.19 Å | A/B=28-402 |
| 7AQG | X-ray | 2.27 Å | A=24-402 |
| 1OC0 | X-ray | 2.28 Å | A=24-402 |
| 6GWP | X-ray | 2.28 Å | A=24-402 |
| 3PB1 | X-ray | 2.3 Å | I=24-402 |
| 3Q02 | X-ray | 2.3 Å | A/B=24-402 |
| 4IC0 | X-ray | 2.32 Å | A/B/C/D=24-402 |
| 6GWQ | X-ray | 2.32 Å | A=24-402 |
| 1DVM | X-ray | 2.4 Å | A/B/C/D=24-402 |
| 4AQH | X-ray | 2.4 Å | A/B/C=24-402 |
| 3UT3 | X-ray | 2.42 Å | A/B/C/D=28-402 |
| 1C5G | X-ray | 2.6 Å | A=1-402 |
| 3EOX | X-ray | 2.61 Å | A=24-402 |
Showing 20 of 29 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.