1LT6: Heat-labile enterotoxin B-pentamer
Heat-labile enterotoxin B-pentamer complexed with metanitrophenylgalactoside. Determined by X-ray diffraction at 2.2 Å resolution. Released 3 Dec 1997.
- Method
- X-ray diffraction
- Resolution
- 2.2 Å
- Organism
- Escherichia coli
- Chains
- 10
- Atoms
- 8,702
- Mol. weight
- 121.09 kDa
- Ligands
- GAA
- Released
- 3 Dec 1997
Explore 1LT6 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
1LT6 contains 42 α-helices and 64 β-strands across 10 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains D and F: 4 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-9 | 5 | |
| β-strand | 15-22 | 8 | 1 |
| β-strand | 26-30 | 5 | 1 |
| β-strand | 37-41 | 5 | 1 |
| β-strand | 47-50 | 4 | 1 |
| α-helix | 51-53 | 3 | |
| α-helix | 59-78 | 20 | |
| α-helix | 80-81 | 2 | |
| β-strand | 82-88 | 7 | 1 |
| β-strand | 94-102 | 9 | 1 |
Chain E: 4 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-10 | 6 | |
| β-strand | 15-23 | 9 | 1 |
| β-strand | 26-30 | 5 | 1 |
| β-strand | 38-41 | 4 | 1 |
| β-strand | 47-50 | 4 | 1 |
| α-helix | 51-53 | 3 | |
| α-helix | 59-77 | 19 | |
| α-helix | 80 | 1 | |
| β-strand | 81-88 | 8 | 1 |
| β-strand | 94-102 | 9 | 1 |
Chain G: 4 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-9 | 5 | |
| β-strand | 15-23 | 9 | 1 |
| β-strand | 26-32 | 7 | 1 |
| β-strand | 35-41 | 7 | 1 |
| β-strand | 47-50 | 4 | 1 |
| α-helix | 51-53 | 3 | |
| α-helix | 61-78 | 18 | |
| α-helix | 80 | 1 | |
| β-strand | 81-88 | 8 | 1 |
| β-strand | 94-100 | 7 | 1 |
Chain H: 5 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-9 | 5 | |
| β-strand | 15-22 | 8 | 1 |
| β-strand | 26-30 | 5 | 1 |
| β-strand | 37-41 | 5 | 1 |
| β-strand | 47-50 | 4 | 1 |
| α-helix | 51-53 | 3 | |
| α-helix | 59-78 | 20 | |
| α-helix | 80-81 | 2 | |
| β-strand | 82-88 | 7 | 1 |
| α-helix | 94 | 1 | |
| β-strand | 95-102 | 8 | 1 |
Chain L: 4 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-10 | 6 | |
| β-strand | 15-22 | 8 | 2 |
| β-strand | 26-30 | 5 | 2 |
| β-strand | 32 | 1 | 3 |
| β-strand | 35 | 1 | 3 |
| β-strand | 38-41 | 4 | 2 |
| β-strand | 47-50 | 4 | 2 |
| α-helix | 51-53 | 3 | |
| α-helix | 61-78 | 18 | |
| α-helix | 80-81 | 2 | |
| β-strand | 82-88 | 7 | 2 |
| β-strand | 94-102 | 9 | 2 |
Chain M: 4 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-10 | 6 | |
| β-strand | 15-22 | 8 | 2 |
| β-strand | 26-30 | 5 | 2 |
| β-strand | 38-41 | 4 | 2 |
| β-strand | 47-50 | 4 | 2 |
| α-helix | 51-53 | 3 | |
| α-helix | 59-78 | 20 | |
| α-helix | 80-81 | 2 | |
| β-strand | 82-88 | 7 | 2 |
| β-strand | 94-102 | 9 | 2 |
Chain N: 5 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-9 | 5 | |
| β-strand | 15-22 | 8 | 2 |
| β-strand | 26-30 | 5 | 2 |
| β-strand | 38-41 | 4 | 2 |
| β-strand | 47-50 | 4 | 2 |
| α-helix | 51-52 | 2 | |
| α-helix | 59-61 | 3 | |
| α-helix | 62-78 | 17 | |
| α-helix | 80-81 | 2 | |
| β-strand | 82-88 | 7 | 2 |
| β-strand | 94-102 | 9 | 2 |
Chain O: 4 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-9 | 5 | |
| β-strand | 15-22 | 8 | 2 |
| β-strand | 26-30 | 5 | 2 |
| β-strand | 32 | 1 | 4 |
| β-strand | 35 | 1 | 4 |
| β-strand | 38-41 | 4 | 2 |
| β-strand | 47-50 | 4 | 2 |
| α-helix | 51-52 | 2 | |
| α-helix | 59-77 | 19 | |
| α-helix | 80-81 | 2 | |
| β-strand | 82-88 | 7 | 2 |
| β-strand | 94-102 | 9 | 2 |
1 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Heat-labile enterotoxin | D, E, F, G, H, L, M, N, O, P | protein | 103 | Escherichia coli | P32890 (AlphaFold model) |
Sequence of entity 1 (D, E, F, G, H, L, M, N, O, P), FASTA
>1LT6_1 HEAT-LABILE ENTEROTOXIN (chains D, E, F, G, H, L, M, N, O, P)
APQTITELCSEYRNTQIYTINDKILSYTESMAGKREMVIITFKSGETFQVEVPGSQHIDS
QKKAIERMKDTLRITYLTETKIDKLCVWNNKTPNSIAAISMKN
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| GAA | 3-nitrophenyl alpha-D-galactopyranoside | C12 H15 N O8 | 10 |
Primary citation
Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin. Merritt, E.A., Sarfaty, S., Feil, I.K. et al. Structure (1997) 5:1485-1499. DOI 10.1016/S0969-2126(97)00298-0 · PubMed
Other PDB entries of the same protein (UniProt P32890 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 1DJR 1.3 Å, Heat-labile enterotoxin B-pentamer complexed with M-carboxyphenyl-alpha-D-galactose
- 6IAL 1.45 Å, Porcine E.coli heat-labile enterotoxin B-pentamer in complex with Lacto-N-neohexaose
- 1EFI 1.6 Å, Heat-labile enterotoxin B-pentamer complexed with para-aminophenyl-alpha-D-galactopyranos…
- 5LZI 1.6 Å, Porcine heat-labile enterotoxin R13H in complex with inhibitor MM146
- 1LT5 1.7 Å, Heat-labile enterotoxin B-pentamer complexed with thiodigalactoside
- 1EEF 1.8 Å, Heat-labile enterotoxin B-pentamer complexed with bound ligand pepg
- 1FD7 1.8 Å, Heat-labile enterotoxin B-pentamer with bound ligand BMSC001
- 2XRS 1.81 Å, Crystal structures exploring the origins of the broader specificity of escherichia coli…
- 1LTS 1.95 Å, Refined structure of E. Coli heat labile enterotoxin, a close relative of cholera toxin
- 1PZI 1.99 Å, Heat-Labile Enterotoxin B-Pentamer Complexed With Nitrophenyl Galactoside 2a
- 1LT3 2.0 Å, Heat-labile enterotoxin double mutant N40C/G166C
- 1LT4 2.0 Å, Heat-labile enterotoxin mutant S63K
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