1MF7: Integrin alpha M I domain

Integrin alpha M I domain. Determined by X-ray diffraction at 1.25 Å resolution. Released 20 May 2003.

Method: X-ray diffraction
Resolution: 1.25 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,806
Mol. weight: 22.23 kDa
Released: 20 May 2003

Explore 1MF7 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1MF7 contains 15 α-helices and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 15 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	133-140	8	1
α-helix	147-164	18
β-strand	169-176	8	1
β-strand	180-184	5	1
α-helix	186-191	6
α-helix	195-199	5
β-strand	209	1	2
α-helix	211-217	7
α-helix	218-222	5
α-helix	225-227	3
α-helix	229-230	2
β-strand	234-241	8	1
β-strand	246	1	2
α-helix	252-254	3
α-helix	256-261	6
β-strand	264-271	8	1
α-helix	273-275	3
α-helix	278-287	10
α-helix	289	1
α-helix	292-295	4
β-strand	296-299	4	1
α-helix	302-308	7
α-helix	309-317	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Integrin alpha M	A	protein	194	Homo sapiens	P11215 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1MF7_1 INTEGRIN ALPHA M (chains A)
CPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFK
EFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVITDGEKFG
DPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKT
IQNQLREKIFCIGS

Primary citation

Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies. McCleverty, C.J., Liddington, R.C. Biochem J (2003) 372:121-127. DOI 10.1042/BJ20021273 · PubMed

Other PDB entries of the same protein (UniProt P11215 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1NA5 1.5 Å, Integrin alpha M I domain
8CE6 1.58 Å, Crystal structure of human Cd11b I domain in P212121 space group
1IDO 1.7 Å, I-domain from integrin CR3, MG2+ bound
1JLM 2.0 Å, I-domain from integrin CR3, MN2+ bound
4XW2 2.0 Å, Structural basis for simvastatin competitive antagonism of complement receptor 3
8CE9 2.11 Å, Crystal structure of human Cd11b I domain in C121 space group
1M1U 2.3 Å, An isoleucine-based allosteric switch controls affinity and shape shifting in integrin…
1N9Z 2.5 Å, Integrin alpha M I domain mutant
9RM9 2.6 Å, Cryo-EM structure of alphaM/beta2 headpiece complex without alphaM I-domain - the…
1BHO 2.7 Å, Mac-1 I domain magnesium complex
1BHQ 2.7 Å, Mac-1 I domain cadmium complex
1IDN 2.7 Å, Mac-1 I domain metal free

Browse structure collections

About this viewer

MolViewer shows 1MF7 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.