1N1A: N-terminal domain of human FKBP52

Crystal Structure of the N-terminal domain of human FKBP52. Determined by X-ray diffraction at 2.4 Å resolution. Released 30 Dec 2002.

Method: X-ray diffraction
Resolution: 2.4 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,919
Mol. weight: 30.67 kDa
Released: 30 Dec 2002

Explore 1N1A in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1N1A contains 7 α-helices and 18 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	23-24	2	1
β-strand	33-39	7	1
β-strand	52-61	10	1
β-strand	66-69	4	1
β-strand	77-80	4	1
α-helix	88-94	7
α-helix	97-98	2
β-strand	102-107	6	1
α-helix	109-111	3
β-strand	118	1	2
β-strand	122	1	2
β-strand	128-138	11	1

Chain B: 4 helices, 9 β-strands

Element	Residues	Length	Sheet
α-helix	19-21	3
β-strand	23-24	2	3
β-strand	33-39	7	3
β-strand	52-61	10	3
β-strand	66-69	4	3
β-strand	77-80	4	3
α-helix	88-94	7
α-helix	97-98	2
β-strand	102-107	6	3
α-helix	109-111	3
β-strand	118	1	4
β-strand	122	1	4
β-strand	128-138	11	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
FKBP52	A, B	protein	140	Homo sapiens	Q02790 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>1N1A_1 FKBP52 (chains A, B)
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGW
LLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPP
KIPPNATLVFEVELFEFKGE

Primary citation

Structure of the N-terminal domain of human FKBP52. Li, P., Ding, Y., Wu, B. et al. Acta Crystallogr D Biol Crystallogr (2003) 59:16-22. DOI 10.1107/S0907444902017523 · PubMed

Other PDB entries of the same protein (UniProt Q02790 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4LAY 1.7 Å, Crystal Structure Analysis of FKBP52, Complex with I63
4DRJ 1.8 Å, o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
4LAV 1.8 Å, Crystal Structure Analysis of FKBP52, Crystal Form II
1Q1C 1.9 Å, Crystal structure of N(1-260) of human FKBP52
4LAX 2.01 Å, Crystal Structure Analysis of FKBP52, Complex with FK506
6RCY 2.3 Å, Crystal structure of FK1 domain of FKBP52 in complex with a bio-inspired hybrid…
4LAW 2.4 Å, Crystal Structure Analysis of FKBP52, Crystal Form III
1P5Q 2.8 Å, Crystal Structure of FKBP52 C-terminal Domain
1QZ2 3.0 Å, Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD…
4TW8 3.0 Å, The Fk1-Fk2 domains of FKBP52 in complex with iFit-FL
8FFV 3.01 Å, Cryo-EM structure of the GR-Hsp90-FKBP52 complex

Browse structure collections

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