Crystal structure of the complex of platelet receptor gpib-alpha and alpha-thrombin at 2.6A. Determined by X-ray diffraction at 2.6 Å resolution. Released 22 Jul 2003.
Explore 1P8V in 3D Show helices and sheets RCSB PDB PDBe
1P8V contains 23 α-helices and 42 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 5-9 | 5 | 1 |
| β-strand | 12-16 | 5 | 1 |
| α-helix | 25-26 | 2 | |
| β-strand | 35-37 | 3 | 1 |
| β-strand | 45-47 | 3 | 2 |
| α-helix | 48-51 | 4 | |
| β-strand | 59-61 | 3 | 1 |
| β-strand | 69-71 | 3 | 2 |
| β-strand | 81-83 | 3 | 1 |
| β-strand | 104-106 | 3 | 1 |
| β-strand | 128-130 | 3 | 1 |
| β-strand | 152-154 | 3 | 1 |
| β-strand | 176-178 | 3 | 1 |
| β-strand | 199-201 | 3 | 1 |
| β-strand | 207 | 1 | 3 |
| α-helix | 211-213 | 3 | |
| α-helix | 214-222 | 9 | |
| α-helix | 224-226 | 3 | |
| β-strand | 227 | 1 | 1 |
| β-strand | 228 | 1 | 4 |
| α-helix | 236-238 | 3 | |
| α-helix | 240 | 1 | |
| β-strand | 241 | 1 | 4 |
| α-helix | 243-245 | 3 | |
| β-strand | 247 | 1 | 5 |
| β-strand | 248 | 1 | 3 |
| β-strand | 255 | 1 | 5 |
| α-helix | 256-258 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 11-13 | 3 | |
| α-helix | 20-24 | 5 | |
| α-helix | 25-27 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 2 | 1 | 6 |
| β-strand | 5-6 | 2 | 7 |
| α-helix | 7-8 | 2 | |
| β-strand | 15-20 | 6 | 8 |
| β-strand | 25-32 | 8 | 8 |
| β-strand | 37-40 | 4 | 8 |
| α-helix | 42-44 | 3 | |
| β-strand | 46-47 | 2 | 9 |
| α-helix | 48-50 | 3 | |
| β-strand | 52-53 | 2 | 9 |
| α-helix | 56-58 | 3 | |
| β-strand | 59-63 | 5 | 8 |
| β-strand | 67 | 1 | 10 |
| β-strand | 77-79 | 3 | 8 |
| β-strand | 81-86 | 6 | 8 |
| β-strand | 91 | 1 | 11 |
| β-strand | 97 | 1 | 11 |
| β-strand | 101-105 | 5 | 8 |
| α-helix | 117-118 | 2 | |
| β-strand | 119 | 1 | 7 |
| α-helix | 120-121 | 2 | |
| α-helix | 123-129 | 7 | |
| β-strand | 135-140 | 6 | 7 |
| β-strand | 159 | 1 | 10 |
| β-strand | 161-168 | 8 | 7 |
| α-helix | 170-174 | 5 | |
| β-strand | 185-188 | 4 | 7 |
| α-helix | 192-194 | 3 | |
| β-strand | 199 | 1 | 6 |
| β-strand | 208-212 | 5 | 7 |
| β-strand | 219-227 | 9 | 7 |
| β-strand | 238-242 | 5 | 7 |
| α-helix | 244-246 | 3 | |
| α-helix | 247-257 | 11 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Platelet glycoprotein Ib alpha chain | A | protein | 279 | Homo sapiens | P07359 (AlphaFold model) |
| Prothrombin | B | protein | 29 | Homo sapiens | P00734 (AlphaFold model) |
| Prothrombin | C | protein | 259 | Homo sapiens | P00734 (AlphaFold model) |
>1P8V_1 Platelet glycoprotein Ib alpha chain (chains A) HPICEVSKVASHLEVNCDKRDLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQL NLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGAL RGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQ ENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMT SNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYY
>1P8V_2 Prothrombin (chains B) EADCGLRPLFEKKSLEDKTERELLESYID
>1P8V_3 Prothrombin (chains C) IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLL VRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL PDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIR ITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFY THVFRLKKWIQKVIDQFGE
| ID | Name | Formula | Copies |
|---|---|---|---|
| DFP | Diisopropyl phosphonate | C6 H15 O3 P | 1 |
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 1 |
Water and common crystallization additives (MES) are not listed.
Crystal Structure of the GpIbalpha-Thrombin Complex Essential for Platelet Aggregation. Dumas, J.J., Kumar, R., Seehra, J. et al. Science (2003) 301:222-226. DOI 10.1126/science.1083917 · PubMed
Other PDB entries of the same protein (UniProt P07359 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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