Platelet glycoprotein Ib alpha chain (GP1BA) is a 652-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P07359.
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The mean pLDDT of this model is 64.3 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 47% |
What pLDDT means and how to read it
GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium
Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage (PubMed:17008541, PubMed:2070794). Interacts with FLNB (PubMed:9651345). Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23) (PubMed:19828450)
Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4CH2 | X-ray | 1.6 Å | P/Q=287-300 |
| 1P9A | X-ray | 1.7 Å | G=17-306 |
| 4CH8 | X-ray | 1.75 Å | P/Q/R/S=287-300 |
| 1M0Z | X-ray | 1.85 Å | A/B=17-306 |
| 3P72 | X-ray | 1.9 Å | A=17-281 |
| 4C2A | X-ray | 2.08 Å | B=17-306 |
| 8WE2 | X-ray | 2.11 Å | Q/R=646-652 |
| 1OOK | X-ray | 2.3 Å | G=17-306 |
| 2BP3 | X-ray | 2.32 Å | S/T=598-619 |
| 4YR6 | X-ray | 2.38 Å | C/F=503-512 |
| 8WF6 | X-ray | 2.47 Å | E/F/Q/R=596-607 |
| 1P8V | X-ray | 2.6 Å | A=17-294 |
| 1SQ0 | X-ray | 2.6 Å | B=17-304 |
| 1GWB | X-ray | 2.8 Å | A/B=16-296 |
| 1QYY | X-ray | 2.8 Å | A/G=17-306 |
| 4C2B | X-ray | 2.8 Å | B/D/F/H=17-306 |
| 1U0N | X-ray | 2.95 Å | D=17-281 |
| 1M10 | X-ray | 3.1 Å | B=17-306 |
| 4MGX | X-ray | 3.16 Å | B=603-611 |
| 3PMH | X-ray | 3.2 Å | G=17-306 |
Showing 20 of 22 experimental structures (best resolution first).
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