1QRQ: Voltage-dependent K+ channel beta subunit

Structure of a voltage-dependent K+ channel beta subunit. Determined by X-ray diffraction at 2.8 Å resolution. Released 27 Oct 1999.

Method: X-ray diffraction
Resolution: 2.8 Å
Organism: Rattus norvegicus
Chains: 4
Atoms: 10,348
Mol. weight: 148.4 kDa
Ligands: NDP
Released: 27 Oct 1999

Explore 1QRQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1QRQ contains 84 α-helices and 56 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B, C and D: 21 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	39-41	3	1
β-strand	48-50	3	1
β-strand	52-55	4	2
α-helix	59-63	5
α-helix	66-78	13
β-strand	83-87	5	2
α-helix	90-93	4
α-helix	94-106	13
α-helix	110-112	3
β-strand	114-119	6	2
β-strand	121	1	3
α-helix	126-128	3
β-strand	129	1	3
α-helix	133-147	15
β-strand	152-157	6	2
α-helix	166-178	13
β-strand	182-188	7	2
α-helix	192-205	14
α-helix	208-210	3
β-strand	212-216	5	2
β-strand	218	1	4
β-strand	221	1	4
α-helix	223	1
α-helix	224-228	5
α-helix	229-236	8
β-strand	239-243	5	2
α-helix	247-252	6
α-helix	258-259	2
α-helix	271-278	8
α-helix	280-299	20
α-helix	303-312	10
β-strand	317-322	6	2
α-helix	327-334	8
α-helix	336-339	4
α-helix	345-355	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Protein (kv BETA2 protein)	A, B, C, D	protein	325	Rattus norvegicus	P62483 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>1QRQ_1 PROTEIN (KV BETA2 PROTEIN) (chains A, B, C, D)
LQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA
EVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVV
FANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQA
EYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKD
KILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIG
AIQVLPKLSSSIVHEIDSILGNKPY

Ligands and cofactors

ID	Name	Formula	Copies
NDP	NADPH dihydro-nicotinamide-adenine-dinucleotide phosphate	C21 H30 N7 O17 P3	4

Primary citation

Structure of a voltage-dependent K+ channel beta subunit. Gulbis, J.M., Mann, S., MacKinnon, R. Cell (1999) 97:943-952. DOI 10.1016/S0092-8674(00)80805-3 · PubMed

Other PDB entries of the same protein (UniProt P62483 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3EAU 1.82 Å, Voltage-dependent K+ channel beta subunit in complex with cortisone
3EB3 2.0 Å, Voltage-dependent K+ channel beta subunit (W121A) in complex with cortisone
3EB4 2.0 Å, Voltage-dependent K+ channel beta subunit (I211R) in complex with cortisone
1EXB 2.1 Å, Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K channels
2R9R 2.4 Å, Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel)…
4JTA 2.5 Å, Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin
4JTD 2.54 Å, Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Lys27Met mutant of…
4JTC 2.56 Å, Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin in Cs+
2A79 2.9 Å, Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
3LNM 2.9 Å, F233W mutant of the Kv2.1 paddle-Kv1.2 chimera channel
3LUT 2.9 Å, A Structural Model for the Full-length Shaker Potassium Channel Kv1.2
6EBL 3.0 Å, The voltage-activated Kv1.2-2.1 paddle chimera channel in lipid nanodiscs, cytosolic…

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