3LUT: Voltage-gated potassium channel subunit beta-2

A Structural Model for the Full-length Shaker Potassium Channel Kv1.2. Determined by X-ray diffraction at 2.9 Å resolution. Released 23 Jun 2010.

Method
X-ray diffraction
Resolution
2.9 Å
Organism
Rattus norvegicus
Chains
2
Atoms
5,848
Mol. weight
98.81 kDa
Ligands
NAP
Released
23 Jun 2010

Explore 3LUT in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3LUT contains 44 α-helices and 18 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 24 helices, 14 β-strands

ElementResiduesLengthSheet
β-strand39-4131
β-strand48-5031
β-strand52-5542
α-helix59-635
α-helix66-7813
β-strand83-8752
α-helix90-934
α-helix94-10613
α-helix110-1123
β-strand114-11962
β-strand12113
α-helix126-1283
β-strand12913
α-helix133-14715
β-strand152-15762
α-helix166-17813
β-strand182-18872
α-helix192-20514
α-helix208-2103
β-strand212-21652
β-strand21814
β-strand22114
α-helix2231
α-helix224-2285
α-helix229-2368
α-helix2381
β-strand239-24352
α-helix247-2526
α-helix264-2663
α-helix271-2777
α-helix280-29819
α-helix303-31210
β-strand317-32262
α-helix327-3348
α-helix336-3394
α-helix340-3423
α-helix345-35511
α-helix358-3603
Chain B: 20 helices, 4 β-strands
ElementResiduesLengthSheet
β-strand34-3965
β-strand42-4765
α-helix48-525
α-helix62-654
α-helix66-683
β-strand69-7025
β-strand75-7845
α-helix82-9312
α-helix106-11510
α-helix120-13011
α-helix141-1444
α-helix151-1577
α-helix164-18421
α-helix203-2053
α-helix220-23920
α-helix254-26916
α-helix279-2824
α-helix290-30213
α-helix303-3097
α-helix312-32312
α-helix325-35026
α-helix361-37212
α-helix387-40317
α-helix406-42015

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Voltage-gated potassium channel subunit beta-2Aprotein367Rattus norvegicusP62483 (AlphaFold model)
Potassium voltage-gated channel subfamily A member 2Bprotein499Rattus norvegicusP63142 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>3LUT_1 Voltage-gated potassium channel subunit beta-2 (chains A)
MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTF
GGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF
WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG
MAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGA
MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG
CTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSILGNKPY
SKKDYRS
Sequence of entity 2 (B), FASTA
>3LUT_2 Potassium voltage-gated channel subfamily A member 2 (chains B)
MTVATGDPVDEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLG
DPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGE
EAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSF
CLETLPIFRDENEDMHGGGVTFHTYSQSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVR
FFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVR
VFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERDSQFPS
IPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE
TEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTA
NCTLANTNYVNITKMLTDV

Ligands and cofactors

IDNameFormulaCopies
NAPNADP nicotinamide-adenine-dinucleotide phosphateC21 H28 N7 O17 P31

Water and common crystallization additives (K) are not listed.

Primary citation

Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement. Chen, X., Wang, Q., Ni, F. et al. Proc Natl Acad Sci U S A (2010) 107:11352-11357. DOI 10.1073/pnas.1000142107 · PubMed

Other PDB entries of the same protein (UniProt P62483 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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