Voltage-gated potassium channel subunit beta-2 (Kcnab2) is a 367-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62483.
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The mean pLDDT of this model is 91.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 87% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:10896669, PubMed:18003609, PubMed:21357749, PubMed:9763623). The beta-2/KCNAB2 subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:21357749). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:9763623). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates…
Homotetramer (PubMed:10399921, PubMed:10884227, PubMed:16002581, PubMed:18004376, PubMed:18806782, PubMed:20360102, PubMed:20534430, PubMed:23705070). Interaction with tetrameric potassium channel alpha subunits gives rise to a heterooctamer (PubMed:10884227, PubMed:16002581, PubMed:18004376, PubMed:18806782, PubMed:20360102, PubMed:20534430, PubMed:23705070). Identified in potassium channel…
Cytoplasm, Membrane, Cell membrane, Cell projection, axon, Synapse, synaptosome, Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3EAU | X-ray | 1.82 Å | A=35-361 |
| 3EB3 | X-ray | 2.0 Å | A=35-361 |
| 3EB4 | X-ray | 2.0 Å | A=35-361 |
| 1EXB | X-ray | 2.1 Å | A=36-367 |
| 2R9R | X-ray | 2.4 Å | A/G=36-367 |
| 4JTA | X-ray | 2.5 Å | A/P=36-367 |
| 4JTD | X-ray | 2.54 Å | A/G=36-367 |
| 4JTC | X-ray | 2.56 Å | A/G=36-367 |
| 1QRQ | X-ray | 2.8 Å | A/B/C/D=36-360 |
| 2A79 | X-ray | 2.9 Å | A=36-367 |
| 3LNM | X-ray | 2.9 Å | A/C=35-367 |
| 3LUT | X-ray | 2.9 Å | A=1-367 |
| 6EBL | EM | 3.0 Å | A/C/E/G=37-367 |
| 7SIZ | X-ray | 3.1 Å | A/C=35-367 |
| 5WIE | X-ray | 3.3 Å | A/G=35-367 |
| 6EBK | EM | 3.3 Å | A/C/E/G=37-367 |
| 7SIT | X-ray | 3.32 Å | A/C=35-367 |
| 6CI1 | EM | 4.9 Å | A/B/C/D/E/F/G/H=36-361 |
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