Crystal Structure of the Complex of the Wild-type Von Willebrand Factor A1 domain and Glycoprotein Ib alpha at 2.6 Angstrom Resolution. Determined by X-ray diffraction at 2.6 Å resolution. Released 13 Apr 2004.
Explore 1SQ0 in 3D Show helices and sheets RCSB PDB PDBe
1SQ0 contains 17 α-helices and 28 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 511 | 1 | 1 |
| β-strand | 513-520 | 8 | 2 |
| β-strand | 522 | 1 | 3 |
| α-helix | 527-543 | 17 | |
| β-strand | 551-558 | 8 | 2 |
| β-strand | 562-566 | 5 | 2 |
| α-helix | 574-583 | 10 | |
| α-helix | 584-586 | 3 | |
| β-strand | 589 | 1 | 3 |
| α-helix | 594-600 | 7 | |
| α-helix | 601-605 | 5 | |
| β-strand | 615-622 | 8 | 2 |
| α-helix | 628-630 | 3 | |
| α-helix | 634-643 | 10 | |
| β-strand | 646-653 | 8 | 2 |
| α-helix | 659-668 | 10 | |
| β-strand | 675-677 | 3 | 2 |
| α-helix | 680-682 | 3 | |
| α-helix | 687-695 | 9 | |
| α-helix | 699 | 1 | |
| β-strand | 700 | 1 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 5-9 | 5 | 2 |
| β-strand | 12-16 | 5 | 2 |
| α-helix | 25-26 | 2 | |
| β-strand | 35-37 | 3 | 2 |
| β-strand | 45-47 | 3 | 4 |
| α-helix | 48-51 | 4 | |
| β-strand | 59-61 | 3 | 2 |
| β-strand | 69-71 | 3 | 4 |
| β-strand | 81-83 | 3 | 2 |
| β-strand | 104-106 | 3 | 2 |
| β-strand | 128-130 | 3 | 2 |
| β-strand | 152-154 | 3 | 2 |
| β-strand | 176-178 | 3 | 2 |
| β-strand | 199-201 | 3 | 2 |
| β-strand | 207 | 1 | 5 |
| α-helix | 211-213 | 3 | |
| α-helix | 214-222 | 9 | |
| β-strand | 227-232 | 6 | 2 |
| β-strand | 237-241 | 5 | 2 |
| α-helix | 243-245 | 3 | |
| β-strand | 247 | 1 | 6 |
| β-strand | 248 | 1 | 5 |
| β-strand | 255 | 1 | 6 |
| α-helix | 256-258 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Von Willebrand factor (vWF) [Contains: Von Willebrand antigen II] | A | protein | 214 | Homo sapiens | P04275 (AlphaFold model) |
| Platelet glycoprotein Ib alpha chain (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha)… | B | protein | 288 | Homo sapiens | P07359 (AlphaFold model) |
>1SQ0_1 Von Willebrand factor (vWF) [Contains: Von Willebrand antigen II] (chains A) MEDISEPPLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAV VEYHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKIDRPEAS RIALLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAF VLSSVDELEQQRDEIVSYLCDLAPEAPPPTLPPH
>1SQ0_2 Platelet glycoprotein Ib alpha chain (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (CD42B-alpha) (CD42B) [Contains: Glycocalicin] (chains B) HPICEVSKVASHLEVNCDKRDLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQL NLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGAL RGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNDLTELPAGLLNGLENLDTLLLQ ENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQGVDVKAMT SNVASVQCDNSDKFPVYKYPGKGCPTLGDEGDTDLYDYYPEEDTEGDK
Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations. Dumas, J.J., Kumar, R., McDonagh, T. et al. J Biol Chem (2004) 279:23327-23334. DOI 10.1074/jbc.M401659200 · PubMed
Other PDB entries of the same protein (UniProt P04275 (AlphaFold model), which also has an AlphaFold model), best resolution first:
1SQ0 is part of these collections:
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