1Z6T: Apoptotic protease-activating factor 1

Structure of the apoptotic protease-activating factor 1 bound to ADP. Determined by X-ray diffraction at 2.21 Å resolution. Released 19 Apr 2005.

Method

X-ray diffraction

Resolution

2.21 Å

Organism

Homo sapiens

Chains

4

Atoms

19,663

Mol. weight

273.13 kDa

Ligands

ADP

Released

19 Apr 2005

Explore 1Z6T in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1Z6T contains 168 α-helices and 32 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 43 helices, 8 β-strands

Molecules and chains

>1Z6T_1 Apoptotic protease activating factor 1 (chains A, B, C, D)
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP
QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNG

Ligands and cofactors

Primary citation

Structure of the apoptotic protease-activating factor 1 bound to ADP. Riedl, S.J., Li, W., Chao, Y. et al. Nature (2005) 434:926-933. DOI 10.1038/nature03465 · PubMed

Related structures

Other PDB entries of the same protein (UniProt O14727 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 1CY5 1.3 Å, Crystal structure of the apaf-1 card
• 2P1H 1.59 Å, Rapid Folding and Unfolding of Apaf-1 CARD
• 2YGS 1.6 Å, Card domain from apaf-1
• 4RHW 2.1 Å, Crystal structure of Apaf-1 CARD and caspase-9 CARD complex
• 3YGS 2.5 Å, Apaf-1 card in complex with prodomain of procaspase-9
• 8XQK 2.85 Å, The Crystal Structure of Apaf from Biortus.
• 5WVC 2.99 Å, Structure of the CARD-CARD disk
• 3JBT 3.8 Å, Atomic structure of the Apaf-1 apoptosome
• 5JUY 4.1 Å, Active human apoptosome with procaspase-9
• 5WVE 4.4 Å, Apaf-1-Caspase-9 holoenzyme
• 3J2T 9.5 Å, An improved model of the human apoptosome
• 1C15 Solution structure of apaf-1 card

Browse structure collections

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