1Z92: Interleukin-2 with its alpha receptor

structure of interleukin-2 with its alpha receptor. Determined by X-ray diffraction at 2.8 Å resolution. Released 7 Jun 2005.

Method: X-ray diffraction
Resolution: 2.8 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,971
Mol. weight: 40.21 kDa
Released: 7 Jun 2005

Explore 1Z92 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1Z92 contains 10 α-helices and 18 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	7-28	22
α-helix	36-39	4
β-strand	44-45	2	1
α-helix	53-55	3
α-helix	56-60	5
α-helix	63-70	8
α-helix	82-97	16
β-strand	111-112	2	1
α-helix	114-131	18

Chain B: 3 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	0-1	2
β-strand	2	1	2
α-helix	3	1
β-strand	13-17	5	3
β-strand	25-27	3	4
β-strand	34-36	3	5
β-strand	43-45	3	4
β-strand	46	1	6
β-strand	55	1	6
β-strand	61-63	3	5
α-helix	107-109	3
β-strand	119-120	2	4
β-strand	122	1	2
β-strand	126-131	6	3
β-strand	136-140	5	7
β-strand	144-146	3	3
β-strand	147-148	2	8
β-strand	155-156	2	8
β-strand	161-164	4	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interleukin-2	A	protein	133	Homo sapiens	P60568 (AlphaFold model)
Interleukin-2 receptor alpha chain	B	protein	219	Homo sapiens	P01589 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1Z92_1 Interleukin-2 (chains A)
APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLE
EELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNR
WITFCQSIISTLT

Sequence of entity 2 (B), FASTA

>1Z92_2 Interleukin-2 receptor alpha chain (chains B)
DPELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQ
CQCTSSATRNTTKQVTPQPEEQKERKTTEMQSPMQPVDQASLPGHCREPPPWENEATERI
YHFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQPQLICTGEMETSQFPGEEKP
QASPEGRPESETSCLVTTTDFQIQTEMAATMETSIFTTE

Primary citation

The structure of interleukin-2 complexed with its alpha receptor. Rickert, M., Wang, X., Boulanger, M.J. et al. Science (2005) 308:1477-1480. DOI 10.1126/science.1109745 · PubMed

Other PDB entries of the same protein (UniProt P60568 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8SOZ 1.64 Å, Structure of the complex formed by human interleukin-2 and scFv 602
8SOW 1.71 Å, Structure of the complex formed by human interleukin-2 and scFv F10
7M2G 1.79 Å, INTERLEUKIN-2 (human) mutant P65K, C125S
4NEJ 1.92 Å, Small molecular fragment bound to crystal contact interface of Interleukin-2
4NEM 1.93 Å, Small molecular fragment bound to crystal contact interface of Interleukin-2
1M48 1.95 Å, Crystal Structure of Human IL-2 Complexed with (R)-N-[2-[1-(Aminoiminomethyl)-3-piperidin…
5LQB 1.95 Å, Complex structure of human IL2 mutant, Proleukin, with Fab fragment of NARA1 antibody
1M47 1.99 Å, Crystal Structure of Human Interleukin-2
1M49 2.0 Å, Crystal Structure of Human Interleukin-2 Complexed with SP-1985
1M4B 2.15 Å, Crystal Structure of Human Interleukin-2 K43C Covalently Modified at C43 with…
1M4A 2.18 Å, Crystal Structure of Human Interleukin-2 Y31C Covalently Modified at C31 with…
1NBP 2.2 Å, Crystal Structure Of Human Interleukin-2 Y31C Covalently Modified At C31 With…

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