23FA: Human ATR-ATRIP complex with Gartisertib

Cryo-EM structure of human ATR-ATRIP complex with Gartisertib. Determined by electron microscopy at 3.1 Å resolution. Released 26 Aug 2026.

Method
Electron microscopy
Resolution
3.1 Å
Organism
Homo sapiens
Chains
4
Atoms
45,436
Mol. weight
776.63 kDa
Ligands
ZN, MG, A1E5E
Released
26 Aug 2026

Explore 23FA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

23FA contains 330 α-helices and 45 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 140 helices, 24 β-strands

ElementResiduesLengthSheet
α-helix8-103
α-helix11-199
α-helix26-4318
α-helix48-569
α-helix62-632
α-helix64-7815
α-helix80-823
α-helix90-11021
α-helix117-13721
α-helix139-16527
β-strand173-17421
β-strand195-19621
α-helix199-21517
α-helix224-23815
α-helix242-25918
α-helix264-2663
α-helix267-27812
α-helix279-2813
α-helix285-30218
α-helix315-33016
α-helix333-3364
α-helix340-35112
α-helix352-3565
α-helix365-38218
α-helix390-3934
α-helix395-41521
β-strand453-45532
α-helix461-47818
α-helix486-50217
α-helix503-5075
β-strand531-53332
α-helix538-55114
α-helix556-57924
α-helix584-59411
α-helix596-5994
α-helix606-6105
α-helix615-62410
α-helix630-64112
α-helix649-65911
α-helix665-6739
α-helix677-6793
α-helix690-6956
α-helix701-71616
β-strand723-72643
α-helix741-7444
β-strand745-74843
β-strand75814
α-helix765-7706
α-helix776-79116
β-strand79314
α-helix799-81315
α-helix818-83417
α-helix841-86020
α-helix863-87917
α-helix884-89613
α-helix901-91717
α-helix922-9287
α-helix930-94718
α-helix964-98118
α-helix987-100519
α-helix1008-102114
α-helix1025-104319
α-helix1046-106015
α-helix1064-10685
α-helix1072-108211
α-helix1087-109913
α-helix1116-11227
α-helix1127-113913
α-helix1145-116218
α-helix1164-11696
α-helix1171-118313
α-helix1189-120113
α-helix1208-121912
α-helix1220-12223
α-helix1228-12358
α-helix1236-12405
α-helix1243-12486
α-helix1259-12613
α-helix1262-127211
α-helix1281-129212
α-helix1297-131317
α-helix1315-13228
β-strand132515
α-helix1330-134314
α-helix1348-136114
α-helix1390-140617
α-helix1411-142717
α-helix1438-14458
α-helix1448-145710
β-strand147916
β-strand148416
α-helix1487-150014
α-helix1505-152016
α-helix1522-153918
α-helix1542-155615
α-helix1573-159927
α-helix1621-163515
α-helix1638-164710
α-helix1651-166313
α-helix1670-16723
α-helix1673-168210
α-helix1686-169510
α-helix1702-171110
α-helix1715-172814
α-helix1733-174513
α-helix1749-176214
α-helix1766-17683
α-helix1771-178010
α-helix1784-179310
α-helix1800-181213
α-helix1816-183621
α-helix1843-18464
α-helix1848-186821
α-helix1883-18886
α-helix1894-191017
α-helix1916-193318
α-helix1937-194711
α-helix1952-196615
α-helix1969-198315
α-helix1993-201220
α-helix2018-203114
α-helix2036-205318
α-helix2064-207714
α-helix2083-210624
α-helix2113-213220
α-helix2135-21406
α-helix2142-21476
α-helix2155-217016
α-helix2172-21776
α-helix2188-220417
α-helix2208-222619
β-strand2236-223837
α-helix2244-22507
β-strand225918
α-helix22701
β-strand227115
α-helix22721
β-strand229218
β-strand2293-229647
β-strand2299-230247
β-strand2310-231677
β-strand2321-232887
α-helix2333-235119
α-helix2353-23575
β-strand2367-237157
β-strand2374-237857
β-strand2383-238539
α-helix2386-239611
α-helix2400-24023
α-helix2403-24086
α-helix2417-24237
α-helix2424-24285
α-helix2436-24438
α-helix2447-247125
β-strand2481-248449
β-strand2490-249239
α-helix2501-25044
α-helix2517-25215
α-helix2531-254515
α-helix2547-255812
α-helix2588-260013
α-helix2613-26142
α-helix2616-262712
α-helix2630-26345
Chain B: 146 helices, 21 β-strands
ElementResiduesLengthSheet
α-helix8-103
α-helix11-177
α-helix18-203
α-helix26-4419
α-helix48-569
α-helix62-632
α-helix64-7815
α-helix90-11122
α-helix114-1163
α-helix117-13721
α-helix139-16426
β-strand173-175310
β-strand194-196310
α-helix199-22022
α-helix223-23816
α-helix242-25817
α-helix264-27815
α-helix285-30218
α-helix309-3124
α-helix315-33016
α-helix333-3364
α-helix340-35112
α-helix352-3565
α-helix365-38218
α-helix390-41728
β-strand453-455311
α-helix461-47818
α-helix486-50217
α-helix503-5075
β-strand531-533311
α-helix538-55316
α-helix556-57924
α-helix584-59411
α-helix596-5983
α-helix606-6105
α-helix618-6269
α-helix630-64112
α-helix649-66012
α-helix665-6739
α-helix676-6794
α-helix690-6967
α-helix702-71514
β-strand723-726412
α-helix741-7444
β-strand745-748412
β-strand758113
α-helix765-7673
α-helix776-79015
β-strand793113
α-helix799-81214
α-helix818-83417
α-helix841-86020
α-helix863-87917
α-helix884-89613
α-helix901-91717
α-helix922-9287
α-helix930-94718
α-helix964-98118
α-helix987-100519
α-helix1008-102114
α-helix1025-10317
α-helix1033-104311
α-helix1046-106015
α-helix1064-10685
α-helix1072-10809
α-helix1087-109913
α-helix1116-11238
α-helix1124-11263
α-helix1127-113812
α-helix1145-116218
α-helix1164-11696
α-helix1172-118312
α-helix1189-120113
α-helix1205-122521
α-helix1227-12348
α-helix1235-12395
α-helix1243-12453
α-helix1249-12513
α-helix1259-12613
α-helix1262-12698
α-helix1281-129212
α-helix1297-131317
α-helix1315-13206
α-helix1330-134314
α-helix1348-136114
α-helix1390-140617
α-helix1411-142717
α-helix1438-14458
α-helix1448-145912
α-helix1487-150014
α-helix1505-152016
α-helix1522-153817
α-helix1542-155615
α-helix1573-159927
α-helix1621-163515
α-helix1638-164710
α-helix1651-166313
α-helix1673-168210
α-helix1686-169510
α-helix1702-171110
α-helix1715-172814
α-helix1734-174512
α-helix1749-176214
α-helix1764-17663
α-helix1767-178014
α-helix1784-179310
α-helix1800-181213
α-helix1816-183722
α-helix1843-18464
α-helix1848-186821
α-helix1883-18886
α-helix1894-191118
α-helix1916-193318
α-helix1937-194610
α-helix1953-196513
α-helix1969-198315
α-helix1993-201220
α-helix2018-203114
α-helix2036-205318
α-helix2063-207816
α-helix2083-210624
α-helix2112-213221
α-helix2135-21395
α-helix2142-21476
α-helix2148-21503
α-helix2154-217017
α-helix2172-21776
α-helix2180-21834
α-helix2188-220417
α-helix2208-222619
α-helix2228-22303
β-strand2237114
α-helix2239-22424
α-helix2244-22507
α-helix22581
β-strand2259115
α-helix22601
α-helix2263-22653
β-strand2292115
β-strand2296116
β-strand2300114
β-strand2301-2302216
β-strand2310-2315616
β-strand2321-2328816
α-helix2333-235119
α-helix2353-23575
β-strand2367-2369316
β-strand2374-2378516
β-strand2383-2385317
α-helix2386-239611
α-helix2400-24023
α-helix2403-24097
α-helix2417-24237
α-helix2424-24285
α-helix2437-24437
α-helix2447-247024
α-helix2478-24803
β-strand2481-2484417
β-strand2490-2492317
α-helix2501-25044
α-helix2517-25215
α-helix2531-254515
α-helix2547-255812
α-helix2588-259811
α-helix2612-26154
α-helix2616-262712
α-helix2630-26334
Chain C: 21 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix308-3169
α-helix329-3324
α-helix372-39120
α-helix415-4195
α-helix420-43415
α-helix468-48720
α-helix490-4967
α-helix537-55115
α-helix554-5574
α-helix560-57314
α-helix580-5856
α-helix590-5945
α-helix600-61213
α-helix620-6234
α-helix631-64111
α-helix649-66820
α-helix682-70221
α-helix711-73323
α-helix737-7404
α-helix745-76117
α-helix767-7759
Chain D: 23 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix308-3169
α-helix329-3324
α-helix372-39019
α-helix414-4185
α-helix419-43820
α-helix468-48619
α-helix490-4978
α-helix537-55115
α-helix5551
α-helix556-5605
α-helix561-57313
α-helix577-5793
α-helix581-5888
α-helix591-5944
α-helix600-61314
α-helix620-6234
α-helix631-64111
α-helix649-66820
α-helix682-70221
α-helix711-73323
α-helix739-7413
α-helix745-76117
α-helix767-77610

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Serine/threonine-protein kinase ATRA, Bprotein2644Homo sapiensQ13535 (AlphaFold model)
ATR-interacting proteinC, Dprotein791Homo sapiensQ8WXE1 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>23FA_1 Serine/threonine-protein kinase ATR (chains A, B)
MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTD
SQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNWIITRLLRIAATPSCHLLH
KKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLS
QLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYG
SPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIK
TLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAG
YESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENL
SSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYS
GLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFY
TKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIY
SHSDDGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWAL
QSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHG
MFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKL
AFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDG
FIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKS
ASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVR
KQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQ
LNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELL
LRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLS
SSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFV
RCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPE
LKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIK
YATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKD
FTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGH
QLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLIT
KVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDD
QHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVST
VDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLY
AAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVV
KSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTW
SVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCEL
EHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMV
GECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGV
ELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHF
YLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTK
AYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVL
MEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTD
KLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANH
ASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLME
FNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVY
MTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRS
TAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMV
NGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNET
GEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGW
TPYM
Sequence of entity 2 (C, D), FASTA
>23FA_2 ATR-interacting protein (chains C, D)
MAGTSAPGSKRRSEPPAPRPGPPPGTGHPPSKRARGFSAAAAPDPDDPFGAHGDFTADDL
EELDTLASQALSQCPAAARDVSSDHKVHRLLDGMSKNPSGKNRETVPIKDNFELEVLQAQ
YKELKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALSDKEKE
FSKKLQSLQSELQFKDAEMNELRTKLQTSERANKLAAPSVSHVSPRKNPSVVIKPEACSP
QFGKTSFPTKESFSANMSLPHPCQTESGYKPLVGREDSKPHSLRGDSIKQEEAQKSFVDS
WRQRSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAGMSGL
RTTGSYDGSFSLSALREAQNLAFTGLNLVARNECSRDGDPAEGGRRAFPLCQLPGAVHFL
PLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVSSGVETNPEDSVCILEGFSVTALS
ILQHLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMTSALRGVADDQGQHPLLK
MLLHLLAFSSAATGHLQASVLTQCLKVLVKLAENTSCDFLPRFQCVFQVLPKCLSPETPL
PSVLLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITSRPDRVALETQWLQLEQEVV
WLLAKLGVQSPLPPVTGSNCQCNVEVVRALTVMLHRQWLTVRRAGGPPRTDQQRRTVRCL
RDTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSMLIRGLPDVTDCEEAALDDLCAAE
TDVEDPEVECG

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn2
MGMagnesium ionMg1
A1E5EGartisertibC25 H29 F2 N9 O32

Primary citation

Mechanistic insights into phosphorylation-driven activation and therapeutic inhibition of human ATR-ATRIP. Wang, L., Wang, M., Zhao, L. et al. To be published.

Other PDB entries of the same protein (UniProt Q13535 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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