23FE: Serine/threonine-protein kinase ATR
Cryo-EM structure of human ATR-ATRIP complex with ATPgammaS, Chk1 and ETAA1. Determined by electron microscopy at 2.9 Å resolution. Released 26 Aug 2026.
- Method
- Electron microscopy
- Resolution
- 2.9 Å
- Organism
- Homo sapiens
- Chains
- 8
- Atoms
- 46,261
- Mol. weight
- 836.65 kDa
- Ligands
- AGS, ZN, MG
- Released
- 26 Aug 2026
Explore 23FE in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
23FE contains 343 α-helices and 43 β-strands across 7 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 150 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 11-19 | 9 | |
| α-helix | 26-43 | 18 | |
| α-helix | 48-56 | 9 | |
| α-helix | 62-63 | 2 | |
| α-helix | 64-78 | 15 | |
| α-helix | 80-82 | 3 | |
| α-helix | 90-112 | 23 | |
| α-helix | 114-116 | 3 | |
| α-helix | 117-137 | 21 | |
| α-helix | 139-165 | 27 | |
| β-strand | 173 | 1 | 1 |
| β-strand | 196 | 1 | 1 |
| α-helix | 199-215 | 17 | |
| α-helix | 224-238 | 15 | |
| α-helix | 242-259 | 18 | |
| α-helix | 263-279 | 17 | |
| α-helix | 285-292 | 8 | |
| α-helix | 294-302 | 9 | |
| α-helix | 315-330 | 16 | |
| α-helix | 333-336 | 4 | |
| α-helix | 340-351 | 12 | |
| α-helix | 352-356 | 5 | |
| α-helix | 365-382 | 18 | |
| α-helix | 389-392 | 4 | |
| α-helix | 393-417 | 25 | |
| β-strand | 453-454 | 2 | 2 |
| α-helix | 461-479 | 19 | |
| α-helix | 487-505 | 19 | |
| β-strand | 531-532 | 2 | 2 |
| α-helix | 537-551 | 15 | |
| α-helix | 556-579 | 24 | |
| α-helix | 584-592 | 9 | |
| α-helix | 596-599 | 4 | |
| α-helix | 606-610 | 5 | |
| α-helix | 614-621 | 8 | |
| α-helix | 630-640 | 11 | |
| α-helix | 649-660 | 12 | |
| α-helix | 665-673 | 9 | |
| α-helix | 690-696 | 7 | |
| α-helix | 701-716 | 16 | |
| β-strand | 723-726 | 4 | 3 |
| α-helix | 741-744 | 4 | |
| β-strand | 745-748 | 4 | 3 |
| β-strand | 759 | 1 | 4 |
| α-helix | 760-769 | 10 | |
| α-helix | 776-791 | 16 | |
| β-strand | 794 | 1 | 4 |
| α-helix | 799-813 | 15 | |
| α-helix | 818-833 | 16 | |
| α-helix | 842-860 | 19 | |
| α-helix | 863-879 | 17 | |
| α-helix | 884-896 | 13 | |
| α-helix | 901-917 | 17 | |
| α-helix | 922-928 | 7 | |
| α-helix | 930-946 | 17 | |
| α-helix | 964-981 | 18 | |
| α-helix | 987-1004 | 18 | |
| α-helix | 1008-1021 | 14 | |
| α-helix | 1025-1031 | 7 | |
| α-helix | 1033-1043 | 11 | |
| α-helix | 1046-1060 | 15 | |
| α-helix | 1064-1068 | 5 | |
| α-helix | 1072-1081 | 10 | |
| α-helix | 1087-1099 | 13 | |
| α-helix | 1116-1139 | 24 | |
| α-helix | 1145-1162 | 18 | |
| α-helix | 1164-1169 | 6 | |
| α-helix | 1171-1182 | 12 | |
| α-helix | 1189-1201 | 13 | |
| α-helix | 1205-1218 | 14 | |
| α-helix | 1222-1225 | 4 | |
| α-helix | 1227-1238 | 12 | |
| α-helix | 1243-1245 | 3 | |
| α-helix | 1249-1251 | 3 | |
| α-helix | 1259-1261 | 3 | |
| α-helix | 1262-1277 | 16 | |
| α-helix | 1281-1291 | 11 | |
| α-helix | 1297-1313 | 17 | |
| α-helix | 1315-1323 | 9 | |
| β-strand | 1325 | 1 | 5 |
| α-helix | 1330-1342 | 13 | |
| α-helix | 1348-1361 | 14 | |
| α-helix | 1382-1384 | 3 | |
| α-helix | 1390-1405 | 16 | |
| α-helix | 1411-1427 | 17 | |
| α-helix | 1438-1445 | 8 | |
| α-helix | 1448-1458 | 11 | |
| β-strand | 1462-1464 | 3 | 6 |
| α-helix | 1466-1468 | 3 | |
| α-helix | 1482-1484 | 3 | |
| α-helix | 1487-1500 | 14 | |
| α-helix | 1505-1515 | 11 | |
| α-helix | 1517-1519 | 3 | |
| α-helix | 1522-1538 | 17 | |
| α-helix | 1542-1556 | 15 | |
| α-helix | 1573-1599 | 27 | |
| α-helix | 1621-1635 | 15 | |
| α-helix | 1638-1647 | 10 | |
| α-helix | 1651-1665 | 15 | |
| α-helix | 1670-1672 | 3 | |
| α-helix | 1673-1682 | 10 | |
| α-helix | 1686-1695 | 10 | |
| α-helix | 1702-1711 | 10 | |
| α-helix | 1715-1728 | 14 | |
| α-helix | 1733-1746 | 14 | |
| α-helix | 1749-1762 | 14 | |
| α-helix | 1766-1768 | 3 | |
| α-helix | 1771-1780 | 10 | |
| α-helix | 1784-1793 | 10 | |
| α-helix | 1800-1812 | 13 | |
| α-helix | 1816-1837 | 22 | |
| α-helix | 1843-1846 | 4 | |
| α-helix | 1848-1864 | 17 | |
| α-helix | 1865-1867 | 3 | |
| α-helix | 1883-1888 | 6 | |
| α-helix | 1894-1910 | 17 | |
| α-helix | 1916-1933 | 18 | |
| α-helix | 1937-1945 | 9 | |
| α-helix | 1952-1965 | 14 | |
| α-helix | 1969-1983 | 15 | |
| α-helix | 1993-2012 | 20 | |
| α-helix | 2018-2031 | 14 | |
| α-helix | 2036-2053 | 18 | |
| α-helix | 2058-2060 | 3 | |
| α-helix | 2063-2077 | 15 | |
| α-helix | 2083-2106 | 24 | |
| α-helix | 2112-2132 | 21 | |
| α-helix | 2135-2140 | 6 | |
| α-helix | 2142-2147 | 6 | |
| α-helix | 2154-2170 | 17 | |
| α-helix | 2172-2183 | 12 | |
| α-helix | 2188-2204 | 17 | |
| α-helix | 2207-2226 | 20 | |
| β-strand | 2236-2237 | 2 | 7 |
| α-helix | 2244-2250 | 7 | |
| α-helix | 2258 | 1 | |
| β-strand | 2259 | 1 | 8 |
| α-helix | 2260 | 1 | |
| α-helix | 2263-2266 | 4 | |
| α-helix | 2268-2269 | 2 | |
| β-strand | 2271 | 1 | 5 |
| α-helix | 2274-2276 | 3 | |
| β-strand | 2292 | 1 | 8 |
| β-strand | 2295-2302 | 8 | 7 |
| α-helix | 2303 | 1 | |
| β-strand | 2310-2315 | 6 | 7 |
| β-strand | 2321-2327 | 7 | 7 |
| α-helix | 2333-2351 | 19 | |
| α-helix | 2353-2357 | 5 | |
| β-strand | 2367-2369 | 3 | 7 |
| β-strand | 2375-2378 | 4 | 7 |
| α-helix | 2379-2380 | 2 | |
| β-strand | 2383-2385 | 3 | 9 |
| α-helix | 2386-2397 | 12 | |
| α-helix | 2400-2402 | 3 | |
| α-helix | 2403-2408 | 6 | |
| α-helix | 2417-2423 | 7 | |
| α-helix | 2424-2428 | 5 | |
| α-helix | 2436-2443 | 8 | |
| α-helix | 2447-2470 | 24 | |
| β-strand | 2481-2484 | 4 | 9 |
| β-strand | 2490-2492 | 3 | 9 |
| α-helix | 2502-2504 | 3 | |
| α-helix | 2517-2522 | 6 | |
| α-helix | 2531-2545 | 15 | |
| α-helix | 2547-2558 | 12 | |
| α-helix | 2582-2584 | 3 | |
| α-helix | 2588-2598 | 11 | |
| α-helix | 2612-2614 | 3 | |
| α-helix | 2616-2627 | 12 | |
| α-helix | 2630-2633 | 4 | |
| α-helix | 2638-2640 | 3 | |
Chain B: 146 helices, 20 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 8-10 | 3 | |
| α-helix | 11-19 | 9 | |
| α-helix | 26-29 | 4 | |
| α-helix | 31-43 | 13 | |
| α-helix | 48-56 | 9 | |
| α-helix | 62-63 | 2 | |
| α-helix | 64-78 | 15 | |
| α-helix | 80-82 | 3 | |
| α-helix | 90-112 | 23 | |
| α-helix | 114-119 | 6 | |
| α-helix | 120-136 | 17 | |
| α-helix | 139-165 | 27 | |
| β-strand | 174 | 1 | 10 |
| β-strand | 195 | 1 | 10 |
| α-helix | 199-220 | 22 | |
| α-helix | 224-238 | 15 | |
| α-helix | 242-257 | 16 | |
| α-helix | 267-278 | 12 | |
| α-helix | 285-302 | 18 | |
| α-helix | 308-312 | 5 | |
| α-helix | 315-331 | 17 | |
| α-helix | 333-336 | 4 | |
| α-helix | 340-351 | 12 | |
| α-helix | 352-356 | 5 | |
| α-helix | 358 | 1 | |
| α-helix | 365-382 | 18 | |
| α-helix | 390-417 | 28 | |
| β-strand | 453-454 | 2 | 11 |
| α-helix | 461-479 | 19 | |
| α-helix | 487-506 | 20 | |
| β-strand | 531-532 | 2 | 11 |
| α-helix | 537-551 | 15 | |
| α-helix | 556-575 | 20 | |
| α-helix | 584-599 | 16 | |
| α-helix | 606-610 | 5 | |
| α-helix | 618-624 | 7 | |
| α-helix | 625-627 | 3 | |
| α-helix | 630-641 | 12 | |
| α-helix | 649-660 | 12 | |
| α-helix | 665-673 | 9 | |
| α-helix | 675-677 | 3 | |
| α-helix | 690-698 | 9 | |
| α-helix | 701-716 | 16 | |
| β-strand | 723-726 | 4 | 12 |
| α-helix | 741-744 | 4 | |
| β-strand | 745-748 | 4 | 12 |
| α-helix | 760-763 | 4 | |
| α-helix | 765-768 | 4 | |
| α-helix | 776-792 | 17 | |
| α-helix | 799-813 | 15 | |
| α-helix | 818-834 | 17 | |
| α-helix | 841-860 | 20 | |
| α-helix | 863-879 | 17 | |
| α-helix | 884-896 | 13 | |
| α-helix | 901-917 | 17 | |
| α-helix | 922-928 | 7 | |
| α-helix | 930-947 | 18 | |
| α-helix | 964-981 | 18 | |
| α-helix | 987-1005 | 19 | |
| α-helix | 1008-1020 | 13 | |
| α-helix | 1025-1042 | 18 | |
| α-helix | 1047-1060 | 14 | |
| α-helix | 1064-1068 | 5 | |
| α-helix | 1073-1080 | 8 | |
| α-helix | 1087-1099 | 13 | |
| α-helix | 1116-1122 | 7 | |
| α-helix | 1127-1139 | 13 | |
| α-helix | 1145-1162 | 18 | |
| α-helix | 1164-1167 | 4 | |
| α-helix | 1171-1183 | 13 | |
| α-helix | 1185-1187 | 3 | |
| α-helix | 1189-1201 | 13 | |
| α-helix | 1207-1210 | 4 | |
| α-helix | 1212-1218 | 7 | |
| α-helix | 1220-1225 | 6 | |
| α-helix | 1229-1234 | 6 | |
| α-helix | 1235-1239 | 5 | |
| α-helix | 1249-1251 | 3 | |
| α-helix | 1259-1261 | 3 | |
| α-helix | 1262-1271 | 10 | |
| α-helix | 1281-1292 | 12 | |
| α-helix | 1297-1313 | 17 | |
| α-helix | 1315-1322 | 8 | |
| β-strand | 1325 | 1 | 13 |
| α-helix | 1330-1342 | 13 | |
| α-helix | 1348-1361 | 14 | |
| α-helix | 1366-1368 | 3 | |
| α-helix | 1390-1406 | 17 | |
| α-helix | 1411-1428 | 18 | |
| α-helix | 1438-1445 | 8 | |
| α-helix | 1448-1457 | 10 | |
| α-helix | 1487-1500 | 14 | |
| α-helix | 1505-1513 | 9 | |
| α-helix | 1517-1519 | 3 | |
| α-helix | 1522-1538 | 17 | |
| α-helix | 1542-1556 | 15 | |
| α-helix | 1573-1597 | 25 | |
| α-helix | 1621-1635 | 15 | |
| α-helix | 1638-1647 | 10 | |
| α-helix | 1651-1664 | 14 | |
| α-helix | 1670-1672 | 3 | |
| α-helix | 1673-1682 | 10 | |
| α-helix | 1686-1695 | 10 | |
| α-helix | 1699-1701 | 3 | |
| α-helix | 1702-1711 | 10 | |
| α-helix | 1715-1728 | 14 | |
| α-helix | 1733-1745 | 13 | |
| α-helix | 1749-1762 | 14 | |
| α-helix | 1771-1780 | 10 | |
| α-helix | 1784-1793 | 10 | |
| α-helix | 1800-1812 | 13 | |
| α-helix | 1816-1836 | 21 | |
| α-helix | 1843-1846 | 4 | |
| α-helix | 1848-1868 | 21 | |
| α-helix | 1883-1887 | 5 | |
| α-helix | 1894-1910 | 17 | |
| α-helix | 1916-1933 | 18 | |
| α-helix | 1937-1946 | 10 | |
| α-helix | 1952-1965 | 14 | |
| α-helix | 1969-1983 | 15 | |
| α-helix | 1989-1991 | 3 | |
| α-helix | 1995-2012 | 18 | |
| α-helix | 2018-2031 | 14 | |
| α-helix | 2036-2053 | 18 | |
| α-helix | 2063-2077 | 15 | |
| α-helix | 2083-2106 | 24 | |
| α-helix | 2113-2132 | 20 | |
| α-helix | 2135-2140 | 6 | |
| α-helix | 2142-2147 | 6 | |
| α-helix | 2154-2170 | 17 | |
| α-helix | 2172-2177 | 6 | |
| α-helix | 2188-2204 | 17 | |
| α-helix | 2207-2227 | 21 | |
| β-strand | 2236-2238 | 3 | 14 |
| α-helix | 2244-2250 | 7 | |
| β-strand | 2259 | 1 | 15 |
| α-helix | 2263-2265 | 3 | |
| β-strand | 2271 | 1 | 13 |
| α-helix | 2289-2291 | 3 | |
| β-strand | 2292 | 1 | 15 |
| β-strand | 2293-2296 | 4 | 14 |
| β-strand | 2299-2302 | 4 | 14 |
| β-strand | 2310-2316 | 7 | 14 |
| β-strand | 2321-2328 | 8 | 14 |
| α-helix | 2333-2351 | 19 | |
| α-helix | 2353-2357 | 5 | |
| β-strand | 2367-2371 | 5 | 14 |
| β-strand | 2374-2378 | 5 | 14 |
| β-strand | 2383-2385 | 3 | 16 |
| α-helix | 2386-2397 | 12 | |
| α-helix | 2403-2408 | 6 | |
| α-helix | 2417-2423 | 7 | |
| α-helix | 2424-2428 | 5 | |
| α-helix | 2429-2431 | 3 | |
| α-helix | 2436-2443 | 8 | |
| α-helix | 2447-2470 | 24 | |
| β-strand | 2481-2484 | 4 | 16 |
| β-strand | 2490-2492 | 3 | 16 |
| α-helix | 2501-2504 | 4 | |
| α-helix | 2517-2521 | 5 | |
| α-helix | 2531-2545 | 15 | |
| α-helix | 2547-2558 | 12 | |
| α-helix | 2588-2599 | 12 | |
| α-helix | 2612-2615 | 4 | |
| α-helix | 2616-2627 | 12 | |
| α-helix | 2630-2633 | 4 | |
Chain C: 20 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 308-316 | 9 | |
| α-helix | 329-334 | 6 | |
| α-helix | 372-391 | 20 | |
| α-helix | 415-419 | 5 | |
| α-helix | 420-438 | 19 | |
| α-helix | 468-486 | 19 | |
| α-helix | 490-496 | 7 | |
| α-helix | 537-551 | 15 | |
| α-helix | 555-557 | 3 | |
| α-helix | 560-573 | 14 | |
| α-helix | 580-586 | 7 | |
| α-helix | 591-594 | 4 | |
| α-helix | 600-612 | 13 | |
| α-helix | 631-640 | 10 | |
| α-helix | 649-668 | 20 | |
| α-helix | 682-702 | 21 | |
| α-helix | 711-733 | 23 | |
| α-helix | 737-740 | 4 | |
| α-helix | 745-761 | 17 | |
| α-helix | 767-776 | 10 | |
Chain D: 20 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 308-316 | 9 | |
| α-helix | 329-332 | 4 | |
| α-helix | 372-390 | 19 | |
| α-helix | 416-419 | 4 | |
| α-helix | 420-438 | 19 | |
| α-helix | 470-488 | 19 | |
| α-helix | 490-497 | 8 | |
| α-helix | 537-551 | 15 | |
| α-helix | 556-559 | 4 | |
| α-helix | 562-573 | 12 | |
| α-helix | 580-588 | 9 | |
| α-helix | 590-594 | 5 | |
| α-helix | 600-613 | 14 | |
| α-helix | 631-641 | 11 | |
| α-helix | 649-668 | 20 | |
| α-helix | 682-704 | 23 | |
| α-helix | 711-733 | 23 | |
| α-helix | 737-740 | 4 | |
| α-helix | 745-761 | 17 | |
| α-helix | 767-776 | 10 | |
Chain E: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 318-319 | 2 | |
Chain G: 3 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| β-strand | 105-107 | 3 | 6 |
| α-helix | 130-136 | 7 | |
| α-helix | 182-199 | 18 | |
| α-helix | 202-207 | 6 | |
Chain H: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 130-136 | 7 | |
| α-helix | 154-157 | 4 | |
| α-helix | 182-207 | 26 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Serine/threonine-protein kinase ATR | A, B | protein | 2644 | Homo sapiens | Q13535 (AlphaFold model) |
| Serine/threonine-protein kinase Chk1 | E, F | protein | 14 | Homo sapiens | O14757 (AlphaFold model) |
| Ewing's tumor-associated antigen 1 | G, H | protein | 250 | Homo sapiens | Q9NY74 (AlphaFold model) |
| ATR-interacting protein | C, D | protein | 791 | Homo sapiens | Q8WXE1 (AlphaFold model) |
Sequence of entity 1 (A, B), FASTA
>23FE_1 Serine/threonine-protein kinase ATR (chains A, B)
MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTD
SQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNWIITRLLRIAATPSCHLLH
KKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLS
QLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYG
SPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIK
TLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAG
YESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENL
SSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYS
GLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFY
TKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIY
SHSDDGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWAL
QSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHG
MFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKL
AFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDG
FIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKS
ASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVR
KQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQ
LNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELL
LRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLS
SSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFV
RCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPE
LKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIK
YATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKD
FTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGH
QLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLIT
KVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDD
QHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVST
VDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLY
AAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVV
KSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTW
SVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCEL
EHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMV
GECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGV
ELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHF
YLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTK
AYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVL
MEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTD
KLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANH
ASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLME
FNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVY
MTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRS
TAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMV
NGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNET
GEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGW
TPYM
Sequence of entity 2 (E, F), FASTA
>23FE_2 Serine/threonine-protein kinase Chk1 (chains E, F)
VKYSSSQPEPRTGL
Sequence of entity 3 (G, H), FASTA
>23FE_3 Ewing's tumor-associated antigen 1 (chains G, H)
MSRRRKHDDSPSPKKTPHKTVAAEECGSVVEPGRRRLRSARGSWPCGAREGPPGPVRQRE
QPPTAALCSKSNPEERYETPKRALKMDSLSSSFSSPNDPDGQNDIFWDQNSPLTKQLGKG
RKKQIYTTDSDEISHIVNRIAPQDEKPTTNSMLDMWIGETAIPCTPSVAKGKSRAKISCT
KLKTQSQEEELMKLAKQFDKNMEELDVIQEQNKRNYDFTQMISETEILSNYKDNIQMWSL
HNIVPEIDNA
Sequence of entity 4 (C, D), FASTA
>23FE_4 ATR-interacting protein (chains C, D)
MAGTSAPGSKRRSEPPAPRPGPPPGTGHPPSKRARGFSAAAAPDPDDPFGAHGDFTADDL
EELDTLASQALSQCPAAARDVSSDHKVHRLLDGMSKNPSGKNRETVPIKDNFELEVLQAQ
YKELKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALSDKEKE
FSKKLQSLQSELQFKDAEMNELRTKLQTSERANKLAAPSVSHVSPRKNPSVVIKPEACSP
QFGKTSFPTKESFSANMSLPHPCQTESGYKPLVGREDSKPHSLRGDSIKQEEAQKSFVDS
WRQRSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAGMSGL
RTTGSYDGSFSLSALREAQNLAFTGLNLVARNECSRDGDPAEGGRRAFPLCQLPGAVHFL
PLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVSSGVETNPEDSVCILEGFSVTALS
ILQHLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMTSALRGVADDQGQHPLLK
MLLHLLAFSSAATGHLQASVLTQCLKVLVKLAENTSCDFLPRFQCVFQVLPKCLSPETPL
PSVLLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITSRPDRVALETQWLQLEQEVV
WLLAKLGVQSPLPPVTGSNCQCNVEVVRALTVMLHRQWLTVRRAGGPPRTDQQRRTVRCL
RDTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSMLIRGLPDVTDCEEAALDDLCAAE
TDVEDPEVECG
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| AGS | Phosphothiophosphoric acid-adenylate ester | C10 H16 N5 O12 P3 S | 2 |
| ZN | Zinc ion | Zn | 4 |
| MG | Magnesium ion | Mg | 4 |
Primary citation
Cryo-EM structure of human ATR-ATRIP complex with ATPgammaS, Chk1 and ETAA1. Wang, M., Wang, L., Cheng, J. et al. To be published.
Other PDB entries of the same protein (UniProt Q13535 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 9ZCY 2.5 Å, Cryo-EM structure of apo-ATR-ATRIP
- 23EW 2.7 Å, Cryo-EM structure of human ATR-ATRIP complex with Berzosertib
- 23FC 2.7 Å, Cryo-EM structure of human ATR-ATRIP complex with ATPgammaS and Chk1
- 9L40 2.87 Å, kinase of ATR bound VE-822 state
- 13DE 2.9 Å, Cryo-EM structure of ATR-ATRIP-ETAA1 AAD (S95D/S111D)
- 23FB 3.0 Å, Cryo-EM structure of human ATR-ATRIP complex with ATPgammaS
- 9ZD3 3.0 Å, Cryo-EM structure of ATR-ATRIP-ETAA1 AAD
- 23FA 3.1 Å, Cryo-EM structure of human ATR-ATRIP complex with Gartisertib
- 23EX 3.2 Å, Cryo-EM structure of human ATR-ATRIP complex with Ceralasertib
- 23EY 3.2 Å, Cryo-EM structure of human ATR-ATRIP complex with Elimusertib
- 9L4B 3.2 Å, Kinase domain of ATR bound with RP-3500
- 9ZD1 3.2 Å, Cryo-EM structure of ATR-ATRIP-TOPBP1 AAD
Browse structure collections
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