23FC: Human ATR-ATRIP complex with ATPgammaS and Chk1

Cryo-EM structure of human ATR-ATRIP complex with ATPgammaS and Chk1. Determined by electron microscopy at 2.7 Å resolution. Released 13 May 2026.

Method
Electron microscopy
Resolution
2.7 Å
Organism
Homo sapiens
Chains
6
Atoms
45,559
Mol. weight
779.9 kDa
Ligands
ZN, MG, AGS
Released
13 May 2026

Explore 23FC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

23FC contains 347 α-helices and 45 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 154 helices, 23 β-strands

ElementResiduesLengthSheet
α-helix11-2010
α-helix26-294
α-helix32-409
α-helix41-466
α-helix48-569
α-helix62-632
α-helix64-7815
α-helix80-823
α-helix90-11223
α-helix114-1163
α-helix117-13721
α-helix139-16527
β-strand173-17421
β-strand195-19621
α-helix199-21517
α-helix217-2204
α-helix225-23814
α-helix242-25918
α-helix263-27816
α-helix285-30218
α-helix315-33016
α-helix333-3364
α-helix340-35112
α-helix352-3565
α-helix365-38218
α-helix389-3924
α-helix393-41725
β-strand454-45522
α-helix456-4583
α-helix461-47515
α-helix476-4805
α-helix481-4833
α-helix487-50620
β-strand532-53322
α-helix537-55115
α-helix559-57921
α-helix584-59411
α-helix596-6016
α-helix606-6105
α-helix614-62411
α-helix625-6273
α-helix630-64112
α-helix649-66012
α-helix665-6728
α-helix675-6795
α-helix690-6978
α-helix701-71616
α-helix717-7193
β-strand723-72643
α-helix741-7444
β-strand745-74843
α-helix757-7582
β-strand75914
α-helix760-7623
α-helix763-7664
α-helix767-7704
α-helix776-79116
β-strand79414
α-helix799-81214
α-helix818-83316
α-helix841-86020
α-helix863-87917
α-helix884-89613
α-helix901-91717
α-helix922-9287
α-helix930-94718
α-helix964-98118
α-helix987-100519
α-helix1008-102114
α-helix1025-104319
α-helix1046-106015
α-helix1064-10685
α-helix1072-10809
α-helix1087-109913
α-helix1116-11227
α-helix1127-113711
α-helix1145-116925
α-helix1171-118212
α-helix1189-120214
α-helix1205-12106
α-helix1212-122514
α-helix1229-12346
α-helix1235-12406
α-helix1243-12453
α-helix1249-12513
α-helix1259-12613
α-helix1262-127514
α-helix1281-129111
α-helix1297-131317
α-helix1315-13239
β-strand132515
α-helix1330-134314
α-helix1348-136114
α-helix1390-140617
α-helix1411-142717
α-helix1438-14458
α-helix1448-145912
β-strand147916
β-strand148416
α-helix1487-150014
α-helix1505-151814
α-helix1522-153817
α-helix1542-155615
α-helix1573-159927
α-helix1621-163515
α-helix1638-164710
α-helix1651-166414
α-helix1670-16723
α-helix1673-168210
α-helix1686-169510
α-helix1699-17013
α-helix1702-171110
α-helix1715-172814
α-helix1734-174613
α-helix1749-176214
α-helix1771-178010
α-helix1784-179310
α-helix1800-181213
α-helix1816-183722
α-helix1843-18464
α-helix1848-186821
α-helix1883-18886
α-helix1894-191017
α-helix1916-193318
α-helix1937-19459
α-helix1952-196615
α-helix1969-198315
α-helix1993-201220
α-helix2018-203114
α-helix2036-205419
α-helix2063-207816
α-helix2083-210624
α-helix2112-213221
α-helix2135-21406
α-helix2142-21476
α-helix2148-21503
α-helix2154-217017
α-helix2172-218312
α-helix2188-220417
α-helix2207-222721
β-strand2236-223837
α-helix2239-22424
α-helix2244-22507
α-helix22581
β-strand225918
α-helix22601
α-helix2263-22664
α-helix2268-22692
β-strand227115
β-strand229218
β-strand2295-230287
α-helix23031
β-strand2310-231567
β-strand2321-232777
α-helix2333-235119
α-helix2353-23575
β-strand2367-236937
β-strand2375-237847
α-helix2379-23802
β-strand2383-238539
α-helix2386-239712
α-helix2403-24097
α-helix2417-24237
α-helix2424-24285
α-helix2436-24438
α-helix2447-247024
β-strand2481-248449
β-strand2490-249239
α-helix2501-25044
α-helix2517-25215
α-helix2527-25293
α-helix2531-254515
α-helix2547-255812
α-helix2588-259811
α-helix2612-26154
α-helix2616-262712
α-helix2630-26334
Chain B: 150 helices, 22 β-strands
ElementResiduesLengthSheet
α-helix8-1912
α-helix26-4015
α-helix41-455
α-helix48-569
α-helix62-632
α-helix64-7815
α-helix80-823
α-helix90-11223
α-helix114-1163
α-helix117-13620
α-helix139-16426
β-strand173-175310
β-strand194-196310
α-helix199-22022
α-helix224-23815
α-helix242-25918
α-helix263-27917
α-helix285-30218
α-helix309-3124
α-helix315-33117
α-helix333-3364
α-helix340-35112
α-helix352-3565
α-helix365-38218
α-helix393-41725
β-strand453-455311
α-helix456-4594
α-helix462-47716
α-helix486-50217
α-helix503-5075
β-strand531-533311
α-helix537-55317
α-helix556-57823
α-helix584-59411
α-helix596-6005
α-helix606-6105
α-helix618-6269
α-helix630-64011
α-helix649-66012
α-helix665-6739
α-helix676-6794
α-helix688-6892
α-helix690-6967
α-helix701-71616
β-strand722-726512
α-helix741-7444
β-strand745-749512
β-strand758113
α-helix763-7664
α-helix767-7693
α-helix776-79217
β-strand793113
α-helix799-80911
α-helix812-8143
α-helix818-83417
α-helix841-86020
α-helix863-87917
α-helix884-89613
α-helix901-91717
α-helix922-9287
α-helix930-94718
α-helix964-98017
α-helix987-100519
α-helix1008-102114
α-helix1025-10317
α-helix1033-104311
α-helix1046-106015
α-helix1064-10707
α-helix1072-10798
α-helix1087-109913
α-helix1116-11238
α-helix1127-113812
α-helix1145-116218
α-helix1164-11696
α-helix1172-118312
α-helix1189-120113
α-helix1205-122521
α-helix1227-12348
α-helix1235-12395
α-helix1243-12519
α-helix1262-127110
α-helix1281-129212
α-helix1297-131317
α-helix1315-13228
β-strand1325114
α-helix1330-134314
α-helix1348-136114
α-helix1366-13683
α-helix1390-140617
α-helix1411-142818
α-helix1438-14458
α-helix1448-14547
α-helix1456-14583
α-helix1487-150115
α-helix1505-15128
α-helix1517-15193
α-helix1522-153817
α-helix1542-155615
α-helix1573-159725
α-helix1621-163515
α-helix1638-164710
α-helix1651-166515
α-helix1670-16723
α-helix1673-168210
α-helix1686-169510
α-helix1699-17013
α-helix1702-171110
α-helix1715-172814
α-helix1733-174614
α-helix1749-176214
α-helix1764-178017
α-helix1784-179310
α-helix1800-181213
α-helix1816-183621
α-helix1843-18464
α-helix1848-186821
α-helix1883-18886
α-helix1894-191017
α-helix1916-193318
α-helix1937-194610
α-helix1952-196514
α-helix1969-198315
α-helix1989-19913
α-helix1995-201218
α-helix2018-203114
α-helix2036-205318
α-helix2058-20603
α-helix2063-207614
α-helix2083-210624
α-helix2113-213220
α-helix2135-21395
α-helix2142-21476
α-helix2154-217017
α-helix2172-21798
α-helix2188-220417
α-helix2207-222620
β-strand2236-2238315
α-helix2239-22424
α-helix2244-22507
β-strand2259116
α-helix2263-22664
α-helix2268-22692
β-strand2271114
α-helix2274-22763
β-strand2292116
β-strand2293-2296415
β-strand2299-2302415
β-strand2310-2316715
β-strand2321-2328815
α-helix2333-235119
α-helix2353-23575
β-strand2367-2369315
β-strand2374-2378515
α-helix2379-23802
β-strand2383-2385317
α-helix2386-239712
α-helix2403-24075
α-helix2417-24237
α-helix2424-24285
α-helix2429-24313
α-helix2436-24438
α-helix2447-247125
β-strand2481-2484417
β-strand2490-2492317
α-helix2502-25043
α-helix2517-25226
α-helix2531-254515
α-helix2547-255812
α-helix2588-259811
α-helix2612-26154
α-helix2616-262712
α-helix2630-26334
Chain C: 22 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix308-3169
α-helix329-3346
α-helix372-39120
α-helix415-4195
α-helix420-43819
α-helix468-48619
α-helix490-4967
α-helix537-55115
α-helix555-5562
α-helix557-5615
α-helix562-57312
α-helix580-5878
α-helix591-5944
α-helix600-61415
α-helix620-6223
α-helix631-64111
α-helix649-66820
α-helix682-70120
α-helix711-73323
α-helix737-7404
α-helix745-76117
α-helix767-7759
Chain D: 21 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix308-3169
α-helix329-3324
α-helix372-39019
α-helix415-4195
α-helix420-43819
α-helix468-48619
α-helix490-4978
α-helix537-55115
α-helix5551
α-helix556-5616
α-helix562-57211
α-helix580-5889
α-helix591-5933
α-helix600-61213
α-helix631-64111
α-helix649-66820
α-helix682-70423
α-helix711-73323
α-helix737-7404
α-helix745-75814
α-helix767-77610

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Serine/threonine-protein kinase ATRA, Bprotein2644Homo sapiensQ13535 (AlphaFold model)
ATR-interacting proteinC, Dprotein791Homo sapiensQ8WXE1 (AlphaFold model)
Serine/threonine-protein kinase Chk1E, Fprotein14Homo sapiensO14757 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>23FC_1 Serine/threonine-protein kinase ATR (chains A, B)
MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTD
SQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNWIITRLLRIAATPSCHLLH
KKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLS
QLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYG
SPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIK
TLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAG
YESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENL
SSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYS
GLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFY
TKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIY
SHSDDGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWAL
QSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHG
MFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKL
AFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDG
FIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKS
ASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVR
KQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQ
LNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELL
LRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLS
SSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFV
RCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPE
LKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIK
YATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKD
FTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGH
QLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLIT
KVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDD
QHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVST
VDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLY
AAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVV
KSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTW
SVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCEL
EHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMV
GECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGV
ELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHF
YLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTK
AYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVL
MEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTD
KLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANH
ASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLME
FNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVY
MTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRS
TAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMV
NGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNET
GEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGW
TPYM
Sequence of entity 2 (C, D), FASTA
>23FC_2 ATR-interacting protein (chains C, D)
MAGTSAPGSKRRSEPPAPRPGPPPGTGHPPSKRARGFSAAAAPDPDDPFGAHGDFTADDL
EELDTLASQALSQCPAAARDVSSDHKVHRLLDGMSKNPSGKNRETVPIKDNFELEVLQAQ
YKELKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALSDKEKE
FSKKLQSLQSELQFKDAEMNELRTKLQTSERANKLAAPSVSHVSPRKNPSVVIKPEACSP
QFGKTSFPTKESFSANMSLPHPCQTESGYKPLVGREDSKPHSLRGDSIKQEEAQKSFVDS
WRQRSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAGMSGL
RTTGSYDGSFSLSALREAQNLAFTGLNLVARNECSRDGDPAEGGRRAFPLCQLPGAVHFL
PLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVSSGVETNPEDSVCILEGFSVTALS
ILQHLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMTSALRGVADDQGQHPLLK
MLLHLLAFSSAATGHLQASVLTQCLKVLVKLAENTSCDFLPRFQCVFQVLPKCLSPETPL
PSVLLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITSRPDRVALETQWLQLEQEVV
WLLAKLGVQSPLPPVTGSNCQCNVEVVRALTVMLHRQWLTVRRAGGPPRTDQQRRTVRCL
RDTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSMLIRGLPDVTDCEEAALDDLCAAE
TDVEDPEVECG
Sequence of entity 3 (E, F), FASTA
>23FC_3 Serine/threonine-protein kinase Chk1 (chains E, F)
VKYSSSQPEPRTGL

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn4
MGMagnesium ionMg4
AGSPhosphothiophosphoric acid-adenylate esterC10 H16 N5 O12 P3 S2

Primary citation

Cryo-EM structure of human ATR-ATRIP complex with ATPgammaS and Chk1. Wang, L., Wang, M., Zhao, L. et al. To be published.

Other PDB entries of the same protein (UniProt Q13535 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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