13DE: ATR-ATRIP-ETAA1 AAD
Cryo-EM structure of ATR-ATRIP-ETAA1 AAD (S95D/S111D). Determined by electron microscopy at 2.9 Å resolution. Released 5 Aug 2026.
- Method
- Electron microscopy
- Resolution
- 2.9 Å
- Organism
- Homo sapiens
- Chains
- 6
- Atoms
- 47,273
- Mol. weight
- 832.38 kDa
- Ligands
- ZN, MG, ANP
- Released
- 5 Aug 2026
Explore 13DE in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
13DE contains 367 α-helices and 50 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 160 helices, 25 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 8-10 | 3 | |
| α-helix | 11-20 | 10 | |
| α-helix | 21-22 | 2 | |
| α-helix | 26-44 | 19 | |
| α-helix | 49-56 | 8 | |
| α-helix | 62-63 | 2 | |
| α-helix | 64-78 | 15 | |
| α-helix | 80-82 | 3 | |
| α-helix | 90-111 | 22 | |
| α-helix | 114-119 | 6 | |
| α-helix | 120-137 | 18 | |
| α-helix | 139-165 | 27 | |
| β-strand | 174 | 1 | 1 |
| α-helix | 182-186 | 5 | |
| β-strand | 195 | 1 | 1 |
| α-helix | 199-216 | 18 | |
| α-helix | 217-219 | 3 | |
| α-helix | 225-239 | 15 | |
| α-helix | 242-259 | 18 | |
| α-helix | 266-279 | 14 | |
| α-helix | 280-282 | 3 | |
| α-helix | 288-302 | 15 | |
| α-helix | 315-331 | 17 | |
| α-helix | 333-336 | 4 | |
| α-helix | 340-351 | 12 | |
| α-helix | 352-356 | 5 | |
| α-helix | 365-381 | 17 | |
| α-helix | 383-385 | 3 | |
| α-helix | 390-392 | 3 | |
| α-helix | 393-415 | 23 | |
| β-strand | 453-455 | 3 | 2 |
| α-helix | 456-459 | 4 | |
| α-helix | 461-480 | 20 | |
| α-helix | 487-506 | 20 | |
| β-strand | 531-533 | 3 | 2 |
| α-helix | 537-553 | 17 | |
| α-helix | 559-579 | 21 | |
| α-helix | 584-594 | 11 | |
| α-helix | 596-601 | 6 | |
| α-helix | 606-610 | 5 | |
| α-helix | 618-624 | 7 | |
| α-helix | 630-641 | 12 | |
| α-helix | 649-660 | 12 | |
| α-helix | 665-672 | 8 | |
| α-helix | 675-679 | 5 | |
| α-helix | 690-697 | 8 | |
| α-helix | 701-708 | 8 | |
| α-helix | 711-716 | 6 | |
| β-strand | 722-726 | 5 | 3 |
| α-helix | 741-744 | 4 | |
| β-strand | 745-749 | 5 | 3 |
| α-helix | 753-755 | 3 | |
| β-strand | 758-759 | 2 | 4 |
| α-helix | 760-763 | 4 | |
| α-helix | 767-770 | 4 | |
| α-helix | 776-792 | 17 | |
| β-strand | 793-794 | 2 | 4 |
| α-helix | 800-810 | 11 | |
| α-helix | 811-814 | 4 | |
| α-helix | 818-834 | 17 | |
| α-helix | 841-860 | 20 | |
| α-helix | 863-879 | 17 | |
| α-helix | 884-896 | 13 | |
| α-helix | 901-918 | 18 | |
| α-helix | 922-928 | 7 | |
| α-helix | 930-947 | 18 | |
| α-helix | 962-981 | 20 | |
| α-helix | 986-1005 | 20 | |
| α-helix | 1008-1020 | 13 | |
| α-helix | 1025-1031 | 7 | |
| α-helix | 1034-1042 | 9 | |
| α-helix | 1046-1059 | 14 | |
| α-helix | 1064-1070 | 7 | |
| α-helix | 1072-1081 | 10 | |
| α-helix | 1087-1101 | 15 | |
| α-helix | 1116-1123 | 8 | |
| α-helix | 1127-1139 | 13 | |
| α-helix | 1145-1162 | 18 | |
| α-helix | 1164-1169 | 6 | |
| α-helix | 1171-1181 | 11 | |
| α-helix | 1182-1184 | 3 | |
| α-helix | 1189-1202 | 14 | |
| α-helix | 1209-1211 | 3 | |
| α-helix | 1212-1219 | 8 | |
| α-helix | 1220-1222 | 3 | |
| α-helix | 1227-1235 | 9 | |
| α-helix | 1236-1240 | 5 | |
| α-helix | 1249-1251 | 3 | |
| α-helix | 1259-1261 | 3 | |
| α-helix | 1262-1274 | 13 | |
| α-helix | 1281-1292 | 12 | |
| α-helix | 1297-1313 | 17 | |
| α-helix | 1315-1323 | 9 | |
| β-strand | 1325 | 1 | 5 |
| α-helix | 1330-1342 | 13 | |
| α-helix | 1348-1361 | 14 | |
| α-helix | 1366-1368 | 3 | |
| α-helix | 1390-1406 | 17 | |
| α-helix | 1412-1428 | 17 | |
| α-helix | 1438-1445 | 8 | |
| α-helix | 1448-1454 | 7 | |
| α-helix | 1455-1458 | 4 | |
| β-strand | 1462-1464 | 3 | 6 |
| β-strand | 1479 | 1 | 7 |
| β-strand | 1484 | 1 | 7 |
| α-helix | 1487-1500 | 14 | |
| α-helix | 1505-1512 | 8 | |
| α-helix | 1515-1518 | 4 | |
| α-helix | 1522-1539 | 18 | |
| α-helix | 1542-1557 | 16 | |
| α-helix | 1573-1600 | 28 | |
| α-helix | 1623-1635 | 13 | |
| α-helix | 1638-1647 | 10 | |
| α-helix | 1651-1665 | 15 | |
| α-helix | 1669-1672 | 4 | |
| α-helix | 1673-1682 | 10 | |
| α-helix | 1686-1695 | 10 | |
| α-helix | 1699-1701 | 3 | |
| α-helix | 1702-1711 | 10 | |
| α-helix | 1718-1728 | 11 | |
| α-helix | 1734-1746 | 13 | |
| α-helix | 1750-1762 | 13 | |
| α-helix | 1767-1780 | 14 | |
| α-helix | 1784-1794 | 11 | |
| α-helix | 1800-1813 | 14 | |
| α-helix | 1816-1836 | 21 | |
| α-helix | 1843-1846 | 4 | |
| α-helix | 1848-1869 | 22 | |
| α-helix | 1883-1888 | 6 | |
| α-helix | 1894-1911 | 18 | |
| α-helix | 1916-1933 | 18 | |
| α-helix | 1937-1947 | 11 | |
| α-helix | 1952-1965 | 14 | |
| α-helix | 1969-1983 | 15 | |
| α-helix | 1989-1991 | 3 | |
| α-helix | 1994-2012 | 19 | |
| α-helix | 2018-2031 | 14 | |
| α-helix | 2036-2054 | 19 | |
| α-helix | 2058-2060 | 3 | |
| α-helix | 2062-2076 | 15 | |
| α-helix | 2083-2107 | 25 | |
| α-helix | 2112-2132 | 21 | |
| α-helix | 2135-2139 | 5 | |
| α-helix | 2142-2147 | 6 | |
| α-helix | 2154-2170 | 17 | |
| α-helix | 2172-2183 | 12 | |
| α-helix | 2188-2204 | 17 | |
| α-helix | 2208-2227 | 20 | |
| β-strand | 2236-2238 | 3 | 8 |
| α-helix | 2244-2251 | 8 | |
| α-helix | 2255-2257 | 3 | |
| β-strand | 2259 | 1 | 9 |
| α-helix | 2263-2265 | 3 | |
| β-strand | 2271 | 1 | 5 |
| α-helix | 2274-2276 | 3 | |
| β-strand | 2292 | 1 | 9 |
| β-strand | 2293-2296 | 4 | 8 |
| β-strand | 2299-2302 | 4 | 8 |
| β-strand | 2310-2316 | 7 | 8 |
| β-strand | 2321-2328 | 8 | 8 |
| α-helix | 2333-2351 | 19 | |
| α-helix | 2353-2357 | 5 | |
| β-strand | 2367-2369 | 3 | 8 |
| β-strand | 2374-2378 | 5 | 8 |
| α-helix | 2379-2380 | 2 | |
| β-strand | 2383-2385 | 3 | 10 |
| α-helix | 2386-2397 | 12 | |
| α-helix | 2403-2409 | 7 | |
| α-helix | 2417-2423 | 7 | |
| α-helix | 2424-2428 | 5 | |
| α-helix | 2436-2443 | 8 | |
| α-helix | 2447-2471 | 25 | |
| α-helix | 2478-2480 | 3 | |
| β-strand | 2481-2484 | 4 | 10 |
| β-strand | 2490-2492 | 3 | 10 |
| α-helix | 2501-2504 | 4 | |
| α-helix | 2517-2523 | 7 | |
| α-helix | 2531-2545 | 15 | |
| α-helix | 2547-2558 | 12 | |
| α-helix | 2577-2579 | 3 | |
| α-helix | 2588-2600 | 13 | |
| α-helix | 2612-2615 | 4 | |
| α-helix | 2616-2628 | 13 | |
| α-helix | 2630-2633 | 4 | |
| α-helix | 2638-2640 | 3 | |
Chain B: 159 helices, 24 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 8-10 | 3 | |
| α-helix | 11-20 | 10 | |
| α-helix | 21-22 | 2 | |
| α-helix | 26-44 | 19 | |
| α-helix | 49-56 | 8 | |
| α-helix | 62-63 | 2 | |
| α-helix | 64-78 | 15 | |
| α-helix | 80-82 | 3 | |
| α-helix | 90-111 | 22 | |
| α-helix | 114-119 | 6 | |
| α-helix | 120-137 | 18 | |
| α-helix | 139-165 | 27 | |
| β-strand | 174 | 1 | 11 |
| α-helix | 182-186 | 5 | |
| β-strand | 195 | 1 | 11 |
| α-helix | 199-216 | 18 | |
| α-helix | 217-219 | 3 | |
| α-helix | 225-239 | 15 | |
| α-helix | 242-259 | 18 | |
| α-helix | 266-279 | 14 | |
| α-helix | 280-282 | 3 | |
| α-helix | 288-302 | 15 | |
| α-helix | 315-331 | 17 | |
| α-helix | 333-336 | 4 | |
| α-helix | 340-351 | 12 | |
| α-helix | 352-356 | 5 | |
| α-helix | 365-381 | 17 | |
| α-helix | 383-385 | 3 | |
| α-helix | 390-392 | 3 | |
| α-helix | 393-415 | 23 | |
| β-strand | 453-455 | 3 | 12 |
| α-helix | 456-459 | 4 | |
| α-helix | 461-480 | 20 | |
| α-helix | 487-506 | 20 | |
| β-strand | 531-533 | 3 | 12 |
| α-helix | 537-553 | 17 | |
| α-helix | 559-579 | 21 | |
| α-helix | 584-594 | 11 | |
| α-helix | 596-601 | 6 | |
| α-helix | 606-610 | 5 | |
| α-helix | 618-624 | 7 | |
| α-helix | 630-641 | 12 | |
| α-helix | 649-660 | 12 | |
| α-helix | 665-672 | 8 | |
| α-helix | 675-679 | 5 | |
| α-helix | 690-697 | 8 | |
| α-helix | 701-708 | 8 | |
| α-helix | 711-716 | 6 | |
| β-strand | 722-726 | 5 | 13 |
| α-helix | 741-744 | 4 | |
| β-strand | 745-749 | 5 | 13 |
| α-helix | 753-755 | 3 | |
| β-strand | 758-759 | 2 | 14 |
| α-helix | 760-763 | 4 | |
| α-helix | 767-770 | 4 | |
| α-helix | 776-792 | 17 | |
| β-strand | 793-794 | 2 | 14 |
| α-helix | 800-810 | 11 | |
| α-helix | 811-814 | 4 | |
| α-helix | 818-834 | 17 | |
| α-helix | 841-860 | 20 | |
| α-helix | 863-879 | 17 | |
| α-helix | 884-896 | 13 | |
| α-helix | 901-918 | 18 | |
| α-helix | 922-928 | 7 | |
| α-helix | 930-947 | 18 | |
| α-helix | 962-981 | 20 | |
| α-helix | 986-1005 | 20 | |
| α-helix | 1008-1020 | 13 | |
| α-helix | 1025-1031 | 7 | |
| α-helix | 1034-1042 | 9 | |
| α-helix | 1046-1059 | 14 | |
| α-helix | 1064-1070 | 7 | |
| α-helix | 1072-1081 | 10 | |
| α-helix | 1087-1101 | 15 | |
| α-helix | 1116-1123 | 8 | |
| α-helix | 1127-1139 | 13 | |
| α-helix | 1145-1162 | 18 | |
| α-helix | 1164-1169 | 6 | |
| α-helix | 1171-1181 | 11 | |
| α-helix | 1182-1184 | 3 | |
| α-helix | 1189-1202 | 14 | |
| α-helix | 1209-1211 | 3 | |
| α-helix | 1212-1219 | 8 | |
| α-helix | 1220-1222 | 3 | |
| α-helix | 1227-1235 | 9 | |
| α-helix | 1236-1240 | 5 | |
| α-helix | 1242-1245 | 4 | |
| α-helix | 1262-1275 | 14 | |
| α-helix | 1281-1292 | 12 | |
| α-helix | 1297-1313 | 17 | |
| α-helix | 1315-1323 | 9 | |
| β-strand | 1325 | 1 | 15 |
| α-helix | 1330-1342 | 13 | |
| α-helix | 1348-1361 | 14 | |
| α-helix | 1366-1368 | 3 | |
| α-helix | 1390-1406 | 17 | |
| α-helix | 1412-1428 | 17 | |
| α-helix | 1438-1445 | 8 | |
| α-helix | 1448-1454 | 7 | |
| α-helix | 1455-1458 | 4 | |
| β-strand | 1479 | 1 | 16 |
| β-strand | 1484 | 1 | 16 |
| α-helix | 1487-1500 | 14 | |
| α-helix | 1505-1512 | 8 | |
| α-helix | 1515-1518 | 4 | |
| α-helix | 1522-1539 | 18 | |
| α-helix | 1542-1557 | 16 | |
| α-helix | 1573-1600 | 28 | |
| α-helix | 1623-1635 | 13 | |
| α-helix | 1638-1647 | 10 | |
| α-helix | 1651-1665 | 15 | |
| α-helix | 1669-1672 | 4 | |
| α-helix | 1673-1682 | 10 | |
| α-helix | 1686-1695 | 10 | |
| α-helix | 1699-1701 | 3 | |
| α-helix | 1702-1711 | 10 | |
| α-helix | 1718-1728 | 11 | |
| α-helix | 1734-1746 | 13 | |
| α-helix | 1750-1762 | 13 | |
| α-helix | 1767-1780 | 14 | |
| α-helix | 1784-1794 | 11 | |
| α-helix | 1800-1813 | 14 | |
| α-helix | 1816-1836 | 21 | |
| α-helix | 1843-1846 | 4 | |
| α-helix | 1848-1869 | 22 | |
| α-helix | 1883-1888 | 6 | |
| α-helix | 1894-1911 | 18 | |
| α-helix | 1916-1933 | 18 | |
| α-helix | 1937-1947 | 11 | |
| α-helix | 1952-1965 | 14 | |
| α-helix | 1969-1983 | 15 | |
| α-helix | 1989-1991 | 3 | |
| α-helix | 1994-2012 | 19 | |
| α-helix | 2018-2031 | 14 | |
| α-helix | 2036-2054 | 19 | |
| α-helix | 2058-2060 | 3 | |
| α-helix | 2062-2076 | 15 | |
| α-helix | 2083-2107 | 25 | |
| α-helix | 2112-2132 | 21 | |
| α-helix | 2135-2139 | 5 | |
| α-helix | 2142-2147 | 6 | |
| α-helix | 2154-2170 | 17 | |
| α-helix | 2172-2183 | 12 | |
| α-helix | 2188-2204 | 17 | |
| α-helix | 2208-2227 | 20 | |
| β-strand | 2236-2238 | 3 | 17 |
| α-helix | 2244-2251 | 8 | |
| α-helix | 2255-2257 | 3 | |
| β-strand | 2259 | 1 | 18 |
| α-helix | 2263-2265 | 3 | |
| β-strand | 2271 | 1 | 15 |
| α-helix | 2274-2276 | 3 | |
| β-strand | 2292 | 1 | 18 |
| β-strand | 2293-2296 | 4 | 17 |
| β-strand | 2299-2302 | 4 | 17 |
| β-strand | 2310-2316 | 7 | 17 |
| β-strand | 2321-2328 | 8 | 17 |
| α-helix | 2333-2351 | 19 | |
| α-helix | 2353-2357 | 5 | |
| β-strand | 2367-2369 | 3 | 17 |
| β-strand | 2374-2378 | 5 | 17 |
| α-helix | 2379-2380 | 2 | |
| β-strand | 2383-2385 | 3 | 19 |
| α-helix | 2386-2397 | 12 | |
| α-helix | 2403-2409 | 7 | |
| α-helix | 2417-2423 | 7 | |
| α-helix | 2424-2428 | 5 | |
| α-helix | 2436-2443 | 8 | |
| α-helix | 2447-2471 | 25 | |
| α-helix | 2478-2480 | 3 | |
| β-strand | 2481-2484 | 4 | 19 |
| β-strand | 2490-2492 | 3 | 19 |
| α-helix | 2501-2504 | 4 | |
| α-helix | 2517-2523 | 7 | |
| α-helix | 2531-2545 | 15 | |
| α-helix | 2547-2558 | 12 | |
| α-helix | 2577-2579 | 3 | |
| α-helix | 2588-2600 | 13 | |
| α-helix | 2612-2615 | 4 | |
| α-helix | 2616-2628 | 13 | |
| α-helix | 2630-2633 | 4 | |
| α-helix | 2638-2640 | 3 | |
Chains C and D: 21 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 305-316 | 12 | |
| α-helix | 329-333 | 5 | |
| α-helix | 372-390 | 19 | |
| α-helix | 414-419 | 6 | |
| α-helix | 420-441 | 22 | |
| α-helix | 465-488 | 24 | |
| α-helix | 490-496 | 7 | |
| α-helix | 537-551 | 15 | |
| α-helix | 555-574 | 20 | |
| α-helix | 577-583 | 7 | |
| α-helix | 586-588 | 3 | |
| α-helix | 590-593 | 4 | |
| α-helix | 600-613 | 14 | |
| α-helix | 620-624 | 5 | |
| α-helix | 631-641 | 11 | |
| α-helix | 649-668 | 20 | |
| α-helix | 682-701 | 20 | |
| α-helix | 711-733 | 23 | |
| α-helix | 737-740 | 4 | |
| α-helix | 745-761 | 17 | |
| α-helix | 767-777 | 11 | |
Chain E: 4 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| β-strand | 105-107 | 3 | 6 |
| α-helix | 112-116 | 5 | |
| α-helix | 132-137 | 6 | |
| α-helix | 150-157 | 8 | |
| α-helix | 183-205 | 23 | |
Chain F: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 132-137 | 6 | |
| α-helix | 183-205 | 23 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Serine/threonine-protein kinase ATR | A, B | protein | 2663 | Homo sapiens | Q13535 (AlphaFold model) |
| ATR-interacting protein | C, D | protein | 810 | Homo sapiens | Q8WXE1 (AlphaFold model) |
| Ewing's tumor-associated antigen 1 | E, F | protein | 205 | Homo sapiens | Q9NY74 (AlphaFold model) |
Sequence of entity 1 (A, B), FASTA
>13DE_1 Serine/threonine-protein kinase ATR (chains A, B)
MDYKDDDDKENLYFQGGGRMGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFI
DRILTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSN
WIITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHR
RNVMGHAVEWPVVMSRFLSQLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVF
FRRQELLLWQIGCVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLV
EMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDL
LKAALCHLLQYFLKFVPAGYESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALK
MESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSI
LWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQ
HKSKKKPSVVITWMSLDFYTKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSS
FEDHILEDLCGMLSLPWIYSHSDDGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLT
LFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSD
IVKKEFASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKAS
VCKPFLFLLKKKIPSPVKLAFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVR
VAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAK
GDLVPFALLHLLHCLLSKSASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESL
HSSQMTALPNTPCQNADVRKQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPD
LAAKASPAASALIRTLGKQLNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETE
IELGSLLRQDFQGLHNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMAD
YLQPKLLGILAFFNMQLLSSSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTG
LRFKDDFPELCCRAWDCFVRCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIEN
RDAVQDFLHEIYFLPDHPELKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRI
HALTSLKETLYKNQEKLIKYATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGEL
GAIDPGRLDFSTTETQGKDFTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAI
QELLSIYDCREMETNGPGHQLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLS
KLGSNFAEWSASWAGYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCN
QEDQQEVYAEIMAVLKHDDQHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKA
EKCPHSKSNRNKVDSMVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESF
ITEKKQNIQEHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATAC
YDRAIQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKL
SQWDLVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFER
GSYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPIL
ALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAK
WLWSKGDVHQALIVLQKGVELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAI
MKKYKDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQ
FIYQSMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTA
FSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKA
IHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIP
LQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKF
YIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVN
NTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFL
RTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNK
GETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDP
LVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVH
YLIQEATDENLLCQMYLGWTPYM
Sequence of entity 2 (C, D), FASTA
>13DE_2 ATR-interacting protein (chains C, D)
MDYKDDDDKENLYFQGGGRMAGTSAPGSKRRSEPPAPRPGPPPGTGHPPSKRARGFSAAA
APDPDDPFGAHGDFTADDLEELDTLASQALSQCPAAARDVSSDHKVHRLLDGMSKNPSGK
NRETVPIKDNFELEVLQAQYKELKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLEEQRR
SHFLLEQEKTQALSDKEKEFSKKLQSLQSELQFKDAEMNELRTKLQTSERANKLAAPSVS
HVSPRKNPSVVIKPEACSPQFGKTSFPTKESFSANMSLPHPCQTESGYKPLVGREDSKPH
SLRGDSIKQEEAQKSFVDSWRQRSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSSESPA
GTPLQPPGFGSTLAGMSGLRTTGSYDGSFSLSALREAQNLAFTGLNLVARNECSRDGDPA
EGGRRAFPLCQLPGAVHFLPLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVSSGVE
TNPEDSVCILEGFSVTALSILQHLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGD
MTSALRGVADDQGQHPLLKMLLHLLAFSSAATGHLQASVLTQCLKVLVKLAENTSCDFLP
RFQCVFQVLPKCLSPETPLPSVLLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITS
RPDRVALETQWLQLEQEVVWLLAKLGVQSPLPPVTGSNCQCNVEVVRALTVMLHRQWLTV
RRAGGPPRTDQQRRTVRCLRDTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSMLIRG
LPDVTDCEEAALDDLCAAETDVEDPEVECG
Sequence of entity 3 (E, F), FASTA
>13DE_3 Ewing's tumor-associated antigen 1 (chains E, F)
GSGREGPPGPVRQREQPPTAALCSKSNPEERYETPKRALKMDSLSSSFSDPNDPDGQNDI
FWDQNDPLTKQLGKGRKKQIYTTDSDEISHIVNRIAPQDEKPTTNSMLDMWIGETAIPCT
PSVAKGKSRAKISCTKLKTQSQEEELMKLAKQFDKNMEELDVIQEQNKRNYDFTQMISET
EILSNYKDNIQMWSLHNIVPEIDNA
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 4 |
| MG | Magnesium ion | Mg | 4 |
| ANP | Phosphoaminophosphonic acid-adenylate ester | C10 H17 N6 O12 P3 | 2 |
Primary citation
Structural mechanism of TOPBP1 activating the ATR-ATRIP replication checkpoint kinase. Li, B., Yaseen, A., Pavletich, N.P. Nat Struct Mol Biol (2026) 33:1204-1213. DOI 10.1038/s41594-026-01844-1 · PubMed
Other PDB entries of the same protein (UniProt Q13535 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 9ZCY 2.5 Å, Cryo-EM structure of apo-ATR-ATRIP
- 23EW 2.7 Å, Cryo-EM structure of human ATR-ATRIP complex with Berzosertib
- 23FC 2.7 Å, Cryo-EM structure of human ATR-ATRIP complex with ATPgammaS and Chk1
- 9L40 2.87 Å, kinase of ATR bound VE-822 state
- 23FE 2.9 Å, Cryo-EM structure of human ATR-ATRIP complex with ATPgammaS, Chk1 and ETAA1
- 23FB 3.0 Å, Cryo-EM structure of human ATR-ATRIP complex with ATPgammaS
- 9ZD3 3.0 Å, Cryo-EM structure of ATR-ATRIP-ETAA1 AAD
- 23FA 3.1 Å, Cryo-EM structure of human ATR-ATRIP complex with Gartisertib
- 23EX 3.2 Å, Cryo-EM structure of human ATR-ATRIP complex with Ceralasertib
- 23EY 3.2 Å, Cryo-EM structure of human ATR-ATRIP complex with Elimusertib
- 9L4B 3.2 Å, Kinase domain of ATR bound with RP-3500
- 9ZD1 3.2 Å, Cryo-EM structure of ATR-ATRIP-TOPBP1 AAD
Browse structure collections
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