2BFQ: Macro domains are ADP-ribose binding molecules

Macro domains are ADP-ribose binding molecules. Determined by X-ray diffraction at 1.5 Å resolution. Released 18 Jan 2005.

Method: X-ray diffraction
Resolution: 1.5 Å
Organism: ARCHAEOGLOBUS FULGIDUS
Chains: 1
Atoms: 1,666
Mol. weight: 21.57 kDa
Ligands: AR6
Released: 18 Jan 2005

Explore 2BFQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2BFQ contains 7 α-helices and 7 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	2-9	8	1
β-strand	12-18	7	1
α-helix	21-23	3
β-strand	28-33	6	1
α-helix	42-52	11
α-helix	55-70	16
β-strand	81-84	4	1
α-helix	86-91	6
β-strand	95-100	6	1
α-helix	110-130	21
β-strand	134-137	4	1
α-helix	149-162	14
β-strand	170-175	6	1
α-helix	178-191	14

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Hypothetical protein AF1521	A	protein	192	ARCHAEOGLOBUS FULGIDUS	O28751 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2BFQ_1 HYPOTHETICAL PROTEIN AF1521 (chains A)
MEVLFEAKVGDITLKLAQGDITQYPAKAIVNAANKRLEHGGGVAYAIAKACAGDAGLYTE
ISKKAMREQFGRDYIDHGEVVVTPAMNLEERGIKYVFHTVGPICSGMWSEELKEKLYKAF
LGPLEKAEEMGVESIAFPAVSAGIYGCDLEKVVETFLEAVKNFKGSAVKEVALVIYDRKS
AEVALKVFERSL

Ligands and cofactors

ID	Name	Formula	Copies
AR6	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl[hydroxy-[…	C15 H23 N5 O14 P2	1

Primary citation

The Macro Domain is an Adp-Ribose Binding Module. Karras, G.I., Kustatscher, G., Buhecha, H.R. et al. EMBO J (2005) 24:1911. DOI 10.1038/SJ.EMBOJ.7600664 · PubMed

Other PDB entries of the same protein (UniProt O28751 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1VHU 1.34 Å, Crystal structure of a putative phosphoesterase
1HJZ 1.7 Å, Crystal structure of AF1521 protein containing a macroH2A domain
6FX7 1.82 Å, Crystal structure of in vitro evolved Af1521
7WR6 1.96 Å, Crystal structure of ADP-riboxanated caspase-4 in complex with Af1521
2BFR 2.5 Å, The Macro domain is an ADP-ribose binding module

Browse structure collections

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