2H4M: Karyopherin Beta2/Transportin-M9NLS

Karyopherin Beta2/Transportin-M9NLS. Determined by X-ray diffraction at 3.05 Å resolution. Released 24 Oct 2006.

Method

X-ray diffraction

Resolution

3.05 Å

Organism

Homo sapiens

Chains

4

Atoms

12,740

Mol. weight

206.2 kDa

Released

24 Oct 2006

Explore 2H4M in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2H4M contains 127 α-helices and 4 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 67 helices, 1 β-strand

Molecules and chains

>2H4M_1 Transportin-1 (chains A, B)
MEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSE
DEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASK
GELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFL
QFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALV
MLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKL
IPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIGGSGGSGDTISDWNLRKCSAAALDV
LANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQ
CLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFA
TLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQML
MPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAML
NNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQ
SSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQP
YIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIR
DNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVG
DENWRRFSDQFPLPLKERLAAFYGV

>2H4M_2 Heterogeneous nuclear ribonucleoprotein A1 (chains C, D)
GGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGY

Primary citation

Rules for nuclear localization sequence recognition by karyopherin beta 2. Lee, B.J., Cansizoglu, A.E., Louis, T.H. et al. Cell (2006) 126:543-558. DOI 10.1016/j.cell.2006.05.049 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q92973 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 4FDD 2.3 Å, Crystal structure of KAP beta2-PY-NLS
• 2Z5K 2.6 Å, Complex of Transportin 1 with TAP NLS
• 4OO6 2.7 Å, Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma…
• 7CYL 2.7 Å, Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L)
• 5YVI 2.9 Å, Crystal structure of Karyopherin beta2 in complex with FUS(456-526)
• 1QBK 3.0 Å, Structure of the karyopherin BETA2-ran gppnhp nuclear transport complex
• 2QMR 3.0 Å, Karyopherin beta2/transportin
• 2Z5M 3.0 Å, Complex of Transportin 1 with TAP NLS, crystal form 2
• 4FQ3 3.0 Å, Crystal structure of transportin/FUS-NLS
• 5TQC 3.0 Å, Crystal structure of transport factor karyopherin-beta 2 in complex with the PY-NLS of…
• 4JLQ 3.05 Å, Crystal structure of human Karyopherin-beta2 bound to the PY-NLS of Saccharomyces…
• 5J3V 3.05 Å, Crystal structure of human Karyopherin-beta2 bound to the histone H3 tail

Browse structure collections

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