2L7L: Ca2+/calmodulin

Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of calmodulin kinase I. Determined by solution NMR. Released 18 May 2011.

Method: Solution NMR
Organisms: Homo sapiens, Rattus norvegicus
Chains: 2
Atoms: 1,353
Mol. weight: 19.49 kDa
Ligands: CA
Released: 18 May 2011

Explore 2L7L in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2L7L contains 9 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	26-27	2	1
α-helix	29-38	10
α-helix	45-55	11
β-strand	63-64	2	1
α-helix	65-77	13
α-helix	81-92	12
β-strand	100	1	2
α-helix	102-111	10
α-helix	118-128	11
β-strand	136	1	2
α-helix	138-144	7

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	300-319	20

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A	protein	148	Homo sapiens	P0DP23 (AlphaFold model)
Calcium/calmodulin-dependent protein kinase type 1	B	protein	22	Rattus norvegicus	Q63450 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2L7L_1 Calmodulin (chains A)
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN
GTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B), FASTA

>2L7L_2 Calcium/calmodulin-dependent protein kinase type 1 (chains B)
AKSKWKQAFNATAVVRHMRKLQ

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

Fast methionine-based solution structure determination of calcium-calmodulin complexes. Gifford, J.L., Ishida, H., Vogel, H.J. J Biomol NMR (2011) 50:71-81. DOI 10.1007/s10858-011-9495-3 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
7BF1 1.24 Å, Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2…
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
4DJC 1.35 Å, 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
2W73 1.45 Å, High-resolution structure of the complex between calmodulin and a peptide from…
4LZX 1.5 Å, Complex of IQCG and Ca2+-free CaM
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93

Browse structure collections

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