2LL6: CaM

Solution NMR structure of CaM bound to iNOS CaM binding domain peptide. Determined by solution NMR. Released 16 May 2012.

Method: Solution NMR
Organism: Homo sapiens
Chains: 2
Atoms: 1,301
Mol. weight: 18.69 kDa
Released: 16 May 2012

Explore 2LL6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2LL6 contains 9 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	27-28	2	1
α-helix	29-37	9
α-helix	45-55	11
β-strand	62-63	2	1
α-helix	65-75	11
α-helix	82-92	11
β-strand	99-100	2	2
α-helix	102-110	9
α-helix	118-128	11
β-strand	136-137	2	2
α-helix	138-143	6

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	152-163	12

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A	protein	148	Homo sapiens	P0DP23 (AlphaFold model)
Nitric oxide synthase, inducible	B	protein	17	Homo sapiens	P35228 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2LL6_1 Calmodulin (chains A)
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN
GTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B), FASTA

>2LL6_2 Nitric oxide synthase, inducible (chains B)
LKVLVKAVLFACMLMRK

Primary citation

Structure and Dynamics of Calmodulin (CaM) Bound to Nitric Oxide Synthase Peptides: Effects of a Phosphomimetic CaM Mutation. Piazza, M., Futrega, K., Spratt, D.E. et al. Biochemistry (2012) 51:3651-3661. DOI 10.1021/bi300327z · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
7BF1 1.24 Å, Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2…
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
4DJC 1.35 Å, 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
2W73 1.45 Å, High-resolution structure of the complex between calmodulin and a peptide from…
4LZX 1.5 Å, Complex of IQCG and Ca2+-free CaM
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93

Browse structure collections

About this viewer

MolViewer shows 2LL6 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.