2LXB: Sgt2 homodimerization domain

Solution structure of the Sgt2 homodimerization domain. Determined by solution NMR. Released 21 Nov 2012.

Method: Solution NMR
Organism: Saccharomyces cerevisiae
Chains: 2
Atoms: 1,106
Mol. weight: 15.78 kDa
Released: 21 Nov 2012

Explore 2LXB in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2LXB contains 8 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	5-21	17
α-helix	27-44	18
α-helix	51-55	5
α-helix	69-71	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Small glutamine-rich tetratricopeptide repeat-containing protein 2	A, B	protein	74	Saccharomyces cerevisiae	Q12118 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>2LXB_1 Small glutamine-rich tetratricopeptide repeat-containing protein 2 (chains A, B)
SVDSASKEEIAALIVNYFSSIVEKKEISEDGADSLNVAMDCISEAFGFEREAVSGILGKS
EFKGQHLADILNSA

Primary citation

Structures of the Sgt2/SGTA Dimerization Domain with the Get5/UBL4A UBL Domain Reveal an Interaction that Forms a Conserved Dynamic Interface. Chartron, J.W., Vandervelde, D.G., Clemons, W.M. Cell Rep (2012) 2:1620-1632. DOI 10.1016/j.celrep.2012.10.010 · PubMed

Other PDB entries of the same protein (UniProt Q12118 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5LYP 1.55 Å, Crystal structure of the Tpr Domain of Sgt2.
3ZDM 1.8 Å, Crystal structure of the Sgt2 N domain and the Get5 UBL domain complex
5LYN 2.0 Å, Structure of the Tpr Domain of Sgt2 in complex with yeast Ssa1 peptide fragment
2LXC Solution structure of the complex between the Sgt2 homodimerization domain and the Get5…
4ASV Solution structure of the N-terminal dimerisation domain of Sgt2
4ASW Structure of the complex between the N-terminal dimerisation domain of Sgt2 and the UBL…
9LLV Dimer Sgt2 from S.cerevisiae

Browse structure collections

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