2MK7: Alpha-dystroglycan

Tetra-O-GalNAc glycosylated mucin sequence from alpha dystroglycan mucin domain. Determined by solution NMR. Released 4 Feb 2015.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 127
Mol. weight: 1.88 kDa
Ligands: A2G
Released: 4 Feb 2015

Explore 2MK7 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2MK7 contains 1 α-helix and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	7-9	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Alpha-dystroglycan	A	protein	11	Homo sapiens	Q14118 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2MK7_1 Alpha-dystroglycan (chains A)
XPPTTTTKKPX

Ligands and cofactors

ID	Name	Formula	Copies
A2G	2-acetamido-2-deoxy-alpha-D-galactopyranose	C8 H15 N O6	4

Primary citation

Contrasting the conformational effects of alpha-O-GalNAc and alpha-O-Man glycan protein modifications and their impact on the mucin-like region of alpha-dystroglycan. Borgert, A., Foley, B.L., Live, D. Glycobiology (2021) 31:649-661. DOI 10.1093/glycob/cwaa112 · PubMed

Other PDB entries of the same protein (UniProt Q14118 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5GGP 1.6 Å, Crystal structure of N-terminal domain of human protein O-mannose…
5LLK 1.8 Å, Crystal structure of human alpha-dystroglycan
1EG4 2.0 Å, Structure of a dystrophin ww domain fragment in complex with a beta-dystroglycan peptide
7E9K 2.05 Å, Crystal Structure of POMGNT2 in complex with UDP and mono-mannosyl peptide (379Man long…
7E9L 2.1 Å, Crystal Structure of POMGNT2 in complex with UDP and mono-mannosyl peptide (379Man short…
6JJY 2.3 Å, Crystal Structure of KIBRA and beta-Dystroglycan
8UF4 2.43 Å, Crystal structure of wildtype dystroglycan proteolytic domain (juxtamembrane domain)

Browse structure collections

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