2OEW: ALIX/AIP1 Bro1 Domain

Structure of ALIX/AIP1 Bro1 Domain. Determined by X-ray diffraction at 2.55 Å resolution. Released 27 Mar 2007.

Method: X-ray diffraction
Resolution: 2.55 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,910
Mol. weight: 42.74 kDa
Released: 27 Mar 2007

Explore 2OEW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2OEW contains 17 α-helices and 5 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 17 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	8-11	4
β-strand	12	1	1
α-helix	18-25	8
α-helix	36-50	15
α-helix	51-55	5
α-helix	62-76	15
β-strand	93-96	4	1
β-strand	103	1	2
β-strand	107	1	2
β-strand	110-113	4	1
α-helix	116-136	21
α-helix	143-170	28
α-helix	174-176	3
α-helix	177-179	3
α-helix	181-205	25
α-helix	210-231	22
α-helix	241-266	26
α-helix	270-291	22
α-helix	298-314	17
α-helix	315-319	5
α-helix	326-328	3
α-helix	330-332	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Programmed cell death 6-interacting protein	A	protein	380	Homo sapiens	Q8WUM4 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2OEW_1 Programmed cell death 6-interacting protein (chains A)
MHHHHHHHHHHSGQNLYFQGHMATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQY
CRAAEELSKLRRAAVGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAF
DKGSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGA
FLHIKETVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQ
AADYFGDAFKQCQYKDTLPKEVFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQH
AAELIKTVASRYDEYVNVKDFSDKINRALAAAKKDNDFIYHDRVPDLKDLDPIGKATLVK
STPVNVPISQKFTDLFEKMV

Primary citation

Structural and Biochemical Studies of ALIX/AIP1 and Its Role in Retrovirus Budding. Fisher, R.D., Chung, H.Y., Zhai, Q. et al. Cell (2007) 128:841-852. DOI 10.1016/j.cell.2007.01.035 · PubMed

Other PDB entries of the same protein (UniProt Q8WUM4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5WA1 1.87 Å, CHMP4C A232T in complex with ALIX BRO1
5V3R 1.91 Å, CHMP4C in complex with ALIX BRO1
3E1R 2.0 Å, Midbody targeting of the ESCRT machinery by a non-canonical coiled-coil in CEP55
3C3R 2.02 Å, ALIX BRO1 CHMP4C complex
3C3Q 2.1 Å, ALIX Bro1-domain:CHMIP4B co-crystal structure
3C3O 2.15 Å, ALIX Bro1-domain:CHMIP4A co-crystal structure
2ZNE 2.2 Å, Crystal structure of Zn2+-bound form of des3-23ALG-2 complexed with Alix ABS peptide
6KP3 2.2 Å, Structure of sendai virus Y3/ALIX-BRO1 domain complex
2XS1 2.3 Å, Crystal Structure of ALIX in complex with the SIVmac239 PYKEVTEDL Late Domain
2XS8 2.5 Å, Crystal Structure of ALIX in complex with the SIVagmTan-1 AYDPARKLL Late Domain
2R05 2.55 Å, Crystal Structure of ALIX/AIP1 in complex with the HIV-1 YPLASL Late Domain
2OEX 2.58 Å, Structure of ALIX/AIP1 V Domain

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