2OJQ: Alix V domain

Crystal structure of Alix V domain. Determined by X-ray diffraction at 2.87 Å resolution. Released 20 Feb 2007.

Method: X-ray diffraction
Resolution: 2.87 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,704
Mol. weight: 39.19 kDa
Released: 20 Feb 2007

Explore 2OJQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2OJQ contains 14 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 14 helices, 0 β-strands

Element	Residues	Length
α-helix	363-398	36
α-helix	401-405	5
α-helix	406-408	3
α-helix	418-427	10
α-helix	430-471	42
α-helix	479-480	2
α-helix	481-484	4
α-helix	486-516	31
α-helix	518-521	4
α-helix	528-531	4
α-helix	547-575	29
α-helix	581-588	8
α-helix	596-634	39
α-helix	645-699	55

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Programmed cell death 6-interacting protein	A	protein	348	Homo sapiens	Q8WUM4 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2OJQ_1 Programmed cell death 6-interacting protein (chains A)
GAMGSPVSVQQSLAAYNQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDVSGDTVP
QSILTKSRSVIEQGGIQTVDQLIKELPELLQRNREILDESLRLLDEEEATDNDLRAKFKE
RWQRTPSNELYKPLRAEGTNFRTVLDKAVQADGQVKECYQSHRDTIVLLCKPEPELNAAI
PSANPAKTMQGSEVVSVLKSLLSNLDEVKKEREGLENDLKSVNFDMTSKFLTALAQDGVI
NEEALSVTELDRVYGGLTTKVQESLKKQEGLLKNIQVSHQEFSKMKQSNNEANLREEVLK
NLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTER

Primary citation

Structural basis for viral late-domain binding to Alix. Lee, S., Joshi, A., Nagashima, K. et al. Nat Struct Mol Biol (2007) 14:194-199. DOI 10.1038/nsmb1203 · PubMed

Other PDB entries of the same protein (UniProt Q8WUM4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5WA1 1.87 Å, CHMP4C A232T in complex with ALIX BRO1
5V3R 1.91 Å, CHMP4C in complex with ALIX BRO1
3E1R 2.0 Å, Midbody targeting of the ESCRT machinery by a non-canonical coiled-coil in CEP55
3C3R 2.02 Å, ALIX BRO1 CHMP4C complex
3C3Q 2.1 Å, ALIX Bro1-domain:CHMIP4B co-crystal structure
3C3O 2.15 Å, ALIX Bro1-domain:CHMIP4A co-crystal structure
2ZNE 2.2 Å, Crystal structure of Zn2+-bound form of des3-23ALG-2 complexed with Alix ABS peptide
6KP3 2.2 Å, Structure of sendai virus Y3/ALIX-BRO1 domain complex
2XS1 2.3 Å, Crystal Structure of ALIX in complex with the SIVmac239 PYKEVTEDL Late Domain
2XS8 2.5 Å, Crystal Structure of ALIX in complex with the SIVagmTan-1 AYDPARKLL Late Domain
2OEW 2.55 Å, Structure of ALIX/AIP1 Bro1 Domain
2R05 2.55 Å, Crystal Structure of ALIX/AIP1 in complex with the HIV-1 YPLASL Late Domain

Browse structure collections

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