2OT8: Karyopherin Beta2/Transportin-hnRNPM NLS Complex

Karyopherin Beta2/Transportin-hnRNPM NLS Complex. Determined by X-ray diffraction at 3.1 Å resolution. Released 10 Apr 2007.

Method

X-ray diffraction

Resolution

3.1 Å

Organism

Homo sapiens

Chains

4

Atoms

12,802

Mol. weight

200.49 kDa

Released

10 Apr 2007

Explore 2OT8 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2OT8 contains 131 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 66 helices, 0 β-strands

Molecules and chains

>2OT8_1 Transportin-1 (chains A, B)
MEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSE
DEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASK
GELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFL
QFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALV
MLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKL
IPVLVNGMKYSDIDIILLKGDVEGGSGGDDTISDWNLRKCSAAALDVLANVYRDELLPHI
LPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSIT
CWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPY
LAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKD
EDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDK
DFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKAC
FQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEII
NRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGIC
TMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPL
PLKERLAAFYGV

>2OT8_2 Heterogeneous nuclear ribonucleoprotein M (chains C, D)
ERPAQNEKRKEKNIKRGGNRFEPYANPTKR

Primary citation

Structure-based design of a pathway-specific nuclear import inhibitor. Cansizoglu, A.E., Lee, B.J., Zhang, Z.C. et al. Nat Struct Mol Biol (2007) 14:452-454. DOI 10.1038/nsmb1229 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q92973 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 4FDD 2.3 Å, Crystal structure of KAP beta2-PY-NLS
• 2Z5K 2.6 Å, Complex of Transportin 1 with TAP NLS
• 4OO6 2.7 Å, Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma…
• 7CYL 2.7 Å, Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L)
• 5YVI 2.9 Å, Crystal structure of Karyopherin beta2 in complex with FUS(456-526)
• 1QBK 3.0 Å, Structure of the karyopherin BETA2-ran gppnhp nuclear transport complex
• 2QMR 3.0 Å, Karyopherin beta2/transportin
• 2Z5M 3.0 Å, Complex of Transportin 1 with TAP NLS, crystal form 2
• 4FQ3 3.0 Å, Crystal structure of transportin/FUS-NLS
• 5TQC 3.0 Å, Crystal structure of transport factor karyopherin-beta 2 in complex with the PY-NLS of…
• 2H4M 3.05 Å, Karyopherin Beta2/Transportin-M9NLS
• 4JLQ 3.05 Å, Crystal structure of human Karyopherin-beta2 bound to the PY-NLS of Saccharomyces…

Browse structure collections

About this viewer

MolViewer shows 2OT8 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.