2R6P: Major envelope protein E

Fit of E protein and Fab 1A1D-2 into 24 angstrom resolution cryoEM map of Fab complexed with dengue 2 virus. Determined by electron microscopy at 24.0 Å resolution. Released 25 Dec 2007.

Method
Electron microscopy
Resolution
24.0 Å
Organisms
Dengue virus 2 Puerto Rico/PR159-S1/1969, Mus musculus
Chains
7
Atoms
2,006
Mol. weight
221.97 kDa
Released
25 Dec 2007

Explore 2R6P in 3D Show helices and sheets RCSB PDB PDBe

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Major envelope protein EA, B, Cprotein390Dengue virus 2 Puerto Rico/PR159-S1/1969P12823
Heavy chain of 1A1D-2D, Fprotein216Mus musculusP01865 (AlphaFold model)
Light chain of 1A1D-2E, Gprotein206Mus musculusP01660 (AlphaFold model)
Sequence of entity 1 (A, B, C), FASTA
>2R6P_1 Major envelope protein E (chains A, B, C)
MRCIGISNRDFVEGVSSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKQPATLRKYCIE
AKLTNTTTDSRCPTQGEPTLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCK
KNMEGKIVQPENLEYTVVITPHSGEEHAVGNDTGKHGKEVKITPQSSITEAELTGYGTVT
MECSPRTGLDFNEMVLLQMKDKAWLVHRQWFLDLPLPWLPGAGSNWIQKETLVTFKNPHA
KKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGK
FKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPIVTEKDSPV
NIEAEPPFGDSYIIIGVEPGQLKLNWFKKG
Sequence of entity 2 (D, F), FASTA
>2R6P_2 Heavy chain of 1A1D-2 (chains D, F)
EVQLQQSGAELVKPGASVKLSCTASGFNIKDTYMHWVKQRPEQGLEWIGRIDPANGYSKY
DPKFQGKATITADTSSNAAYLQLSSLTSEDTAVYFCARDYEGFAYWGQGTLVTVSSAKTT
PPSVYPLAPGAAAATSSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTL
SSSVTVTSSTWPSQTITCNVAHPASSTKVDKKIEPR
Sequence of entity 3 (E, G), FASTA
>2R6P_3 Light chain of 1A1D-2 (chains E, G)
DIVLTQSPASLAVSLGQRATISCRASESVVRYGNSFMHWYQQKPGQPPKLLIYRASSLES
GIPTRFSGSGSRTDFTLTINPVEADDVATYYCQQTNVDPWAFGGGTKLEIKRADAAPTVS
IFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDRQNGVLNSWTDQDSTYSMSSTLTLT
KDEYERHNSYTCEATSPIVKSFNRNE

Primary citation

Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins. Lok, S.M., Kostyuchenko, V., Nybakken, G.E. et al. Nat Struct Mol Biol (2008) 15:312-317. DOI 10.1038/nsmb.1382 · PubMed

Other PDB entries of the same protein (UniProt P12823), best resolution first:

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