Crystal structure of the Mus81-Eme1 complex. Determined by X-ray diffraction at 2.7 Å resolution. Released 29 Apr 2008.
Explore 2ZIU in 3D Show helices and sheets RCSB PDB PDBe
2ZIU contains 30 α-helices and 26 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 314 | 1 | 1 |
| β-strand | 319-325 | 7 | 2 |
| α-helix | 327-329 | 3 | |
| α-helix | 340-346 | 7 | |
| β-strand | 352-353 | 2 | 2 |
| β-strand | 362-368 | 7 | 2 |
| α-helix | 369 | 1 | |
| β-strand | 384-395 | 12 | 2 |
| α-helix | 396-405 | 10 | |
| α-helix | 408-416 | 9 | |
| β-strand | 422-428 | 7 | 2 |
| α-helix | 434-437 | 4 | |
| α-helix | 441-453 | 13 | |
| β-strand | 458-461 | 4 | 2 |
| α-helix | 465-481 | 17 | |
| β-strand | 488 | 1 | 1 |
| β-strand | 515-516 | 2 | 2 |
| α-helix | 517-527 | 11 | |
| β-strand | 531 | 1 | 3 |
| α-helix | 532-540 | 9 | |
| β-strand | 543 | 1 | 4 |
| α-helix | 548-557 | 10 | |
| α-helix | 561-570 | 10 | |
| α-helix | 574-577 | 4 | |
| β-strand | 585-586 | 2 | 5 |
| β-strand | 591-592 | 2 | 5 |
| α-helix | 594-606 | 13 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 249-251 | 3 | |
| β-strand | 253-256 | 4 | 6 |
| α-helix | 258-261 | 4 | |
| α-helix | 266-275 | 10 | |
| α-helix | 278 | 1 | |
| β-strand | 279-282 | 4 | 6 |
| β-strand | 290-291 | 2 | 7 |
| β-strand | 292-294 | 3 | 6 |
| α-helix | 306-307 | 2 | |
| β-strand | 308 | 1 | 6 |
| α-helix | 309 | 1 | |
| β-strand | 312-317 | 6 | 7 |
| α-helix | 318-326 | 9 | |
| α-helix | 345-354 | 10 | |
| β-strand | 359-364 | 6 | 7 |
| α-helix | 405-418 | 14 | |
| β-strand | 422 | 1 | 7 |
| β-strand | 425-426 | 2 | 7 |
| α-helix | 429-444 | 16 | |
| α-helix | 456-460 | 5 | |
| β-strand | 469 | 1 | 4 |
| α-helix | 478-486 | 9 | |
| α-helix | 494-503 | 10 | |
| α-helix | 507-515 | 9 | |
| α-helix | 520-523 | 4 | |
| β-strand | 531 | 1 | 8 |
| β-strand | 544 | 1 | 8 |
| α-helix | 547-558 | 12 | |
| β-strand | 565 | 1 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Mus81 protein | A | protein | 311 | Danio rerio | Q7SXA9 (AlphaFold model) |
| Crossover junction endonuclease EME1 | B | protein | 341 | Homo sapiens | Q96AY2 (AlphaFold model) |
>2ZIU_1 Mus81 protein (chains A) MSETGRTAMGWHLSPGSYDIVLCVDLCETTGGSSVRKQELVKELQRNSVTFDVRKLNVGD FLWVARERVTPVPGQLRPPVGKELVLDYIIERKRMDDLCGSIIDGRFREQKFRLKRCGLR KPIYLVEECGSAAAHLSIPESTLQQAIVNTQVVDGFFVKRVQDAKESAAYLTIMTRYLQK LYQNCTLFCRSRELEGDGEAESEKMVANLSCSLMAFTEFNYGAIKNKCQTVREVFARQLM QISGVSGDKAAAVLEHYSTVSSLLQAYDKCSSETEKEKLLSSVKYGKLKRNLGPALSRTI YQLYCTRGPLS
>2ZIU_2 Crossover junction endonuclease EME1 (chains B) MGSSHHHHHHSQDPNSEECLKHIIVVLDPVLLQMEGGGQLLGALQTMECRCVIEAQAVPC SVTWRRRAGPSEDREDWVEEPTVLVLLRAEAFVSMIDNGKQGSLDSTMKGKETLQGFVTD ITAKTAGKALSLVIVDQEKCFSAQNPPRRGKQGANKQTKKQQQRQPEASIGSMVSRVDAE EALVDLQLHTEAQAQIVQSWKELADFTCAFTKAVAEAPFKKLRDETTFSFCLESDWAGGV KVDLAGRGLALVWRRQIQQLNRVSLEMASAVVNAYPSPQLLVQAYQQCFSDKERQNLLAD IQVRRGEGVTSTSRRIGPELSRRIYLQMTTLQPHLSLDSAD
Crystal structure of the Mus81-Eme1 complex. Chang, J.H., Kim, J.J., Choi, J.M. et al. Genes Dev (2008) 22:1093-1106. DOI 10.1101/gad.1618708 · PubMed
Other PDB entries of the same protein (UniProt Q7SXA9 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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