3EWV: Calmodulin

Crystal Structure of calmodulin complexed with a peptide. Determined by X-ray diffraction at 2.6 Å resolution. Released 20 Oct 2009.

Method: X-ray diffraction
Resolution: 2.6 Å
Organisms: Homo sapiens, synthetic construct
Chains: 2
Atoms: 1,346
Mol. weight: 19.58 kDa
Ligands: CA
Released: 20 Oct 2009

Explore 3EWV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3EWV contains 9 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	26-27	2	1
α-helix	29-38	10
α-helix	45-53	9
β-strand	63-64	2	1
α-helix	65-73	9
α-helix	82-92	11
β-strand	100	1	2
α-helix	102-111	10
α-helix	118-128	11
β-strand	136	1	2
α-helix	138-146	9

Chain E: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	396-407	12

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A	protein	154	Homo sapiens	P0DP23 (AlphaFold model)
Tumor necrosis factor receptor superfamily member 16	E	protein	17	synthetic construct	P08138 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>3EWV_1 Calmodulin (chains A)
HHHHHHADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINE
VDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGE
KLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (E), FASTA

>3EWV_2 Tumor necrosis factor receptor superfamily member 16 (chains E)
ATLDALLAALRRIQRAD

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

Structural insights into the mechanism of calmodulin binding to death receptors. Cao, P., Zhang, W., Gui, W. et al. Acta Crystallogr D Biol Crystallogr (2014) 70:1604-1613. DOI 10.1107/S1399004714006919 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
7BF1 1.24 Å, Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2…
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
4DJC 1.35 Å, 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
2W73 1.45 Å, High-resolution structure of the complex between calmodulin and a peptide from…
4LZX 1.5 Å, Complex of IQCG and Ca2+-free CaM
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93

Browse structure collections

About this viewer

MolViewer shows 3EWV directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.