3JC6: DNA replication licensing factor MCM2
Structure of the eukaryotic replicative CMG helicase and pumpjack motion. Determined by electron microscopy at 3.7 Å resolution. Released 10 Feb 2016.
- Method
- Electron microscopy
- Resolution
- 3.7 Å
- Organism
- Saccharomyces cerevisiae
- Chains
- 11
- Atoms
- 23,732
- Mol. weight
- 788.77 kDa
- Ligands
- ZN
- Released
- 10 Feb 2016
Explore 3JC6 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
3JC6 contains 119 α-helices and 132 β-strands across 11 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 2: 11 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 203-215 | 13 | |
| α-helix | 226-236 | 11 | |
| α-helix | 246-252 | 7 | |
| α-helix | 254-260 | 7 | |
| α-helix | 264-282 | 19 | |
| α-helix | 311-313 | 3 | |
| β-strand | 314 | 1 | 1 |
| β-strand | 317 | 1 | 1 |
| β-strand | 320-325 | 6 | 1 |
| α-helix | 326-329 | 4 | |
| β-strand | 331-333 | 3 | 1 |
| β-strand | 383-391 | 9 | 1 |
| α-helix | 394-396 | 3 | |
| α-helix | 397-398 | 2 | |
| β-strand | 405-411 | 7 | 1 |
| α-helix | 412-414 | 3 | |
| β-strand | 423-426 | 4 | 1 |
| α-helix | 428 | 1 | |
| β-strand | 429-431 | 3 | 1 |
| β-strand | 446 | 1 | 2 |
| β-strand | 450-452 | 3 | 1 |
| β-strand | 456-458 | 3 | 1 |
Chain 3: 12 helices, 16 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 19-31 | 13 | |
| α-helix | 39-54 | 16 | |
| α-helix | 100-102 | 3 | |
| α-helix | 103-106 | 4 | |
| α-helix | 108-116 | 9 | |
| α-helix | 118-120 | 3 | |
| α-helix | 122-134 | 13 | |
| β-strand | 179-180 | 2 | 3 |
| β-strand | 184-186 | 3 | 4 |
| α-helix | 190-192 | 3 | |
| β-strand | 193 | 1 | 5 |
| β-strand | 196 | 1 | 6 |
| β-strand | 198-203 | 6 | 7 |
| β-strand | 210-213 | 4 | 7 |
| β-strand | 241-243 | 3 | 7 |
| β-strand | 250 | 1 | 6 |
| β-strand | 253 | 1 | 5 |
| β-strand | 255-259 | 5 | 4 |
| α-helix | 260-261 | 2 | |
| α-helix | 262-264 | 3 | |
| α-helix | 270-271 | 2 | |
| β-strand | 274-277 | 4 | 4 |
| α-helix | 280-282 | 3 | |
| β-strand | 291-293 | 3 | 4 |
| β-strand | 296-297 | 2 | 3 |
| β-strand | 298-300 | 3 | 4 |
| β-strand | 319-321 | 3 | 4 |
| β-strand | 327-328 | 2 | 4 |
Chain 4: 9 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 190-195 | 6 | |
| α-helix | 227-236 | 10 | |
| β-strand | 241 | 1 | 8 |
| α-helix | 255-263 | 9 | |
| α-helix | 265-284 | 20 | |
| α-helix | 295-298 | 4 | |
| β-strand | 303 | 1 | 8 |
| β-strand | 325 | 1 | 9 |
| β-strand | 328 | 1 | 10 |
| β-strand | 332-335 | 4 | 11 |
| α-helix | 336-338 | 3 | |
| β-strand | 339-342 | 4 | 12 |
| β-strand | 344-345 | 2 | 13 |
| β-strand | 348 | 1 | 14 |
| β-strand | 358-359 | 2 | 13 |
| β-strand | 365-366 | 2 | 15 |
| α-helix | 380-382 | 3 | |
| β-strand | 383 | 1 | 14 |
| β-strand | 391-394 | 4 | 12 |
| β-strand | 397-400 | 4 | 11 |
| α-helix | 411-413 | 3 | |
| β-strand | 414-417 | 4 | 11 |
| α-helix | 421-423 | 3 | |
| β-strand | 435-436 | 2 | 10 |
| β-strand | 438 | 1 | 9 |
| β-strand | 439-442 | 4 | 11 |
| β-strand | 445 | 1 | 16 |
| β-strand | 453 | 1 | 16 |
| β-strand | 458-461 | 4 | 11 |
| β-strand | 465-466 | 2 | 10 |
Chain 5: 13 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 22-36 | 15 | |
| α-helix | 45-55 | 11 | |
| β-strand | 60-63 | 4 | 17 |
| α-helix | 65-71 | 7 | |
| α-helix | 73-79 | 7 | |
| α-helix | 83-101 | 19 | |
| α-helix | 133-135 | 3 | |
| β-strand | 136-139 | 4 | 17 |
| α-helix | 148-150 | 3 | |
| β-strand | 162-169 | 8 | 18 |
| α-helix | 170-172 | 3 | |
| β-strand | 173 | 1 | 19 |
| β-strand | 176-183 | 8 | 20 |
| β-strand | 190-193 | 4 | 20 |
| α-helix | 206-208 | 3 | |
| β-strand | 241-250 | 10 | 20 |
| β-strand | 253 | 1 | 19 |
| β-strand | 256-260 | 5 | 18 |
| α-helix | 261 | 1 | |
| α-helix | 270-272 | 3 | |
| β-strand | 273-277 | 5 | 18 |
| β-strand | 279 | 1 | 19 |
| α-helix | 280-282 | 3 | |
| β-strand | 291-294 | 4 | 18 |
| β-strand | 298-301 | 4 | 18 |
| α-helix | 324 | 1 | |
| β-strand | 325-329 | 5 | 18 |
| β-strand | 334-335 | 2 | 18 |
Chain 6: 6 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 107-120 | 14 | |
| α-helix | 136-146 | 11 | |
| β-strand | 150-154 | 5 | 21 |
| α-helix | 155-162 | 8 | |
| α-helix | 165-169 | 5 | |
| α-helix | 174-177 | 4 | |
| α-helix | 178-192 | 15 | |
| β-strand | 264-268 | 5 | 21 |
| β-strand | 273-274 | 2 | 22 |
| β-strand | 289-290 | 2 | 22 |
| β-strand | 292-295 | 4 | 23 |
| β-strand | 303 | 1 | 2 |
| β-strand | 354 | 1 | 2 |
| β-strand | 357-362 | 6 | 23 |
| β-strand | 377-381 | 5 | 23 |
| β-strand | 391 | 1 | 23 |
| β-strand | 394-395 | 2 | 23 |
| β-strand | 396-397 | 2 | 24 |
| β-strand | 404-405 | 2 | 25 |
| β-strand | 419-420 | 2 | 15 |
| β-strand | 450-451 | 2 | 25 |
| β-strand | 454-456 | 3 | 23 |
| β-strand | 459-460 | 2 | 24 |
Chain 7: 10 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7 | 1 | 7 |
| α-helix | 14-24 | 11 | |
| α-helix | 62-71 | 10 | |
| β-strand | 77-81 | 5 | 26 |
| α-helix | 82-91 | 10 | |
| α-helix | 103-109 | 7 | |
| α-helix | 112-115 | 4 | |
| α-helix | 120-124 | 5 | |
| α-helix | 140-157 | 18 | |
| β-strand | 201-205 | 5 | 26 |
| α-helix | 217-219 | 3 | |
| β-strand | 225 | 1 | 27 |
| β-strand | 239-246 | 8 | 27 |
| α-helix | 249-251 | 3 | |
| β-strand | 252-253 | 2 | 27 |
| β-strand | 256 | 1 | 28 |
| β-strand | 259-262 | 4 | 29 |
| β-strand | 269-270 | 2 | 29 |
| β-strand | 278 | 1 | 16 |
| β-strand | 298-300 | 3 | 29 |
| β-strand | 306 | 1 | 28 |
| β-strand | 309-316 | 8 | 27 |
| β-strand | 331-336 | 6 | 27 |
| α-helix | 337-339 | 3 | |
| β-strand | 348-353 | 6 | 27 |
| β-strand | 355 | 1 | 27 |
| β-strand | 376-377 | 2 | 27 |
| β-strand | 380-383 | 4 | 27 |
Chain A: 6 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-21 | 18 | |
| α-helix | 35-57 | 23 | |
| α-helix | 58-62 | 5 | |
| α-helix | 68-103 | 36 | |
| α-helix | 125-144 | 20 | |
| β-strand | 162-166 | 5 | 30 |
| β-strand | 188-192 | 5 | 30 |
| α-helix | 193-200 | 8 | |
Chain B: 11 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 11-12 | 2 | |
| α-helix | 13-20 | 8 | |
| β-strand | 24-29 | 6 | 39 |
| α-helix | 62-64 | 3 | |
| β-strand | 69-72 | 4 | 39 |
| α-helix | 73-81 | 9 | |
| β-strand | 85-87 | 3 | 39 |
| α-helix | 88-90 | 3 | |
| α-helix | 95-106 | 12 | |
| α-helix | 119-128 | 10 | |
| α-helix | 130-132 | 3 | |
| α-helix | 141-159 | 19 | |
| α-helix | 160-162 | 3 | |
| β-strand | 164 | 1 | 40 |
| β-strand | 167 | 1 | 40 |
| β-strand | 169 | 1 | 38 |
| α-helix | 175-198 | 24 | |
3 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| DNA replication licensing factor MCM2 | 2 | protein | 868 | Saccharomyces cerevisiae | P29469 (AlphaFold model) |
| DNA replication licensing factor MCM3 | 3 | protein | 971 | Saccharomyces cerevisiae | P24279 (AlphaFold model) |
| DNA replication licensing factor MCM4 | 4 | protein | 933 | Saccharomyces cerevisiae | P30665 (AlphaFold model) |
| Minichromosome maintenance protein 5 | 5 | protein | 775 | Saccharomyces cerevisiae | P29496 (AlphaFold model) |
| DNA replication licensing factor MCM6 | 6 | protein | 1017 | Saccharomyces cerevisiae | P53091 |
| DNA replication licensing factor MCM7 | 7 | protein | 845 | Saccharomyces cerevisiae | P38132 |
| Cell division control protein 45 | E | protein | 672 | Saccharomyces cerevisiae | Q08032 |
| DNA replication complex GINS protein SLD5 | D | protein | 294 | Saccharomyces cerevisiae | Q03406 |
| DNA replication complex GINS protein PSF2 | B | protein | 213 | Saccharomyces cerevisiae | P40359 |
| DNA replication complex GINS protein PSF1 | A | protein | 208 | Saccharomyces cerevisiae | Q12488 |
| DNA replication complex GINS protein PSF3 | C | protein | 194 | Saccharomyces cerevisiae | Q12146 |
Sequence of entity 1 (2), FASTA
>3JC6_1 DNA replication licensing factor MCM2 (chains 2)
MSDNRRRRREEDDSDSENELPPSSPQQHFRGGMNPVSSPIGSPDMINPEGDDNEVDDVPD
IDEVEEQMNEVDLMDDNMYEDYAADHNRDRYDPDQVDDREQQELSLSERRRIDAQLNERD
RLLRNVAYIDDEDEEQEGAAQLDEMGLPVQRRRRRRQYEDLENSDDDLLSDMDIDPLREE
LTLESLSNVKANSYSEWITQPNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSE
SLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDF
PTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIR
ISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKP
GEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEE
EREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVL
LLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLAD
KGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNST
LPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELK
NNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQ
MDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKV
VVDSFVDAQKVSVRRQLRRSFAIYTLGH
Sequence of entity 2 (3), FASTA
>3JC6_2 DNA replication licensing factor MCM3 (chains 3)
MEGSTGFDGDATTFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQ
DDADERDLLGDDDGDDLEKEKKAASSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAY
FIPPAEKALTDLADSMDDVPHPNASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLV
SVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNK
LTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKS
LGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIF
DILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLR
FVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTD
VDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLL
SRFDLLFVVTDDINEIRDRSISEHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINP
EEHSNSGAGVENEGEDDEDHVFEKFNPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYV
QYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKT
VNKVDAKVAANLLRFALLGEDIGNDIDEEESEYEEALSKRSPQKSPKKRQRVRQPASNSG
SPIKSTPRRSTASSVNATPSSARRILRFQDDEQNAGEDDNDIMSPLPADEEAELQRRLQL
GLRVSPRRREHLHAPEEGSSGPLTEVGTPRLPNVSSAGQDDEQQQSVISFDNVEPGTIST
GRLSLISGIIARLMQTEIFEEESYPVASLFERINEELPEEEKFSAQEYLAGLKIMSDRNN
LMVADDKVWRV
Sequence of entity 3 (4), FASTA
>3JC6_3 DNA replication licensing factor MCM4 (chains 4)
MSQQSSSPTKEDNNSSSPVVPNPDSVPPQLSSPALFYSSSSSQGDIYGRNNSQNLSQGEG
NIRAAIGSSPLNFPSSSQRQNSDVFQSQGRQGRIRSSASASGRSRYHSDLRSDRALPTSS
SSLGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNTLDTSSSSAPPSEASEPLRII
WGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSN
LNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKF
YKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEI
DRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVY
DELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTST
IEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGI
LLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVG
LTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAG
IITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDREL
AKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKM
GDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATDP
KTGKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQASDSMSFNELIKQINEHSQDRVES
SDIQEALSRLQQEDKVIVLGEGVRRSVRLNNRV
Sequence of entity 4 (5), FASTA
>3JC6_4 Minichromosome maintenance protein 5 (chains 5)
MSFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYS
LTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENT
SMDTDSLLLNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLS
IMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDP
YIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSI
YNSKNGAGSGRSGGGNGGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQL
SRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGT
AKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCID
EFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNI
DFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMK
RYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRIT
ESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLNQASGTSLSEIRRFEQELKR
RLPIGWSTSYQTLRREFVDTHRFSQLALDKALYALEKHETIQLRHQGQNIYRSGV
Sequence of entity 5 (6), FASTA
>3JC6_5 DNA replication licensing factor MCM6 (chains 6)
MSSPFPADTPSSNRPSNSSPPPSSIGAGFGSSSGLDSQIGSRLHFPSSSQPHVSNSQTGP
FVNDSTQFSSQRLQTDGSATNDMEGNEPARSFKSRALNHVKKVDDVTGEKVREAFEQFLE
DFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPF
LQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGN
GTSAMATRSITTSTSPEQTERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEV
RPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVR
IQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSST
LDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRET
ELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGH
EAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSG
KASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQT
ISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCN
EKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKEL
RKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDV
DDVEMDEEFDNIESQSHAASGNNDDNDDGTGSGVITSEPPADIEEGQSEATARPGTSEKK
KTTVTYDKYVSMMNMIVRKIAEVDREGAEELTAVDIVDWYLLQKENDLGSLAEYWEERRL
AFKVIKRLVKDRILMEIHGTRHNLRDLENEENENNKTVYVIHPNCEVLDQLEPQDSS
Sequence of entity 6 (7), FASTA
>3JC6_6 DNA replication licensing factor MCM7 (chains 7)
MSAALPSIQLPVDYNNLFNEITDFLVTFKQDTLSSDATRNENEDENLDAENIEQHLLEKG
PKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRA
IDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDA
LREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLIT
VRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFM
STRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPY
TGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAP
EIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRG
VYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEV
MEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLM
LDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYV
VQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLV
RVSKESLYQETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRGFTMLQLS
NCIQEYSYLNVWHLINEGNTLKFVDDGTMDTDQEDSLVSTPKLAPQTTASANVSAQDSDI
DLQDA
Sequence of entity 7 (E), FASTA
>3JC6_7 Cell division control protein 45 (chains E)
MYYGISQFSEAYNKILRNSSSHSSCQLVIFVSCLNIDALCATKMLSLLFKKQLVQSQIVP
IFGYSELRRHYSQLDDNINSLLLVGFGGVIDLEAFLEIDPQEYVIDTDEKSGEQSFRRDI
YVLDAHRPWNLDNIFGSQIIQCFDDGTVDDTLGEQKEAYYKLLELDEESGDDELSGDEND
NNGGDDEATDADEVTDEDEEDEDETISNKRGNSSIGPNDLSKRKQRKKQIHEYEGVLEEY
YSQGTTVVNSISAQIYSLLSAIGETNLSNLWLNILGTTSLDIAYAQVYNRLYPLLQDEVK
RLTPSSRNSVKTPDTLTLNIQPDYYLFLLRHSSLYDSFYYSNYVNAKLSLWNENGKKRLH
KMFARMGIPLSTAQETWLYMDHSIKRELGIIFDKNLDRYGLQDIIRDGFVRTLGYRGSIS
ASEFVEALTALLEVGNSTDKDSVKINNDNNDDTDGEEEEDNSAQKLTNLRKRWVSNFWLS
WDALDDRKVELLNRGIQLAQDLQRAIFNTGVAILEKKLIKHLRIYRLCVLQDGPDLDLYR
NPLTLLRLGNWLIECCAESEDKQLLPMVLASIDENTDTYLVAGLTPRYPRGLDTIHTKKP
ILNNFSMAFQQITAETDAKVRIDNFESSIIEIRREDLSPFLEKLTLSGLLDYKDHDGDYK
DHDIDYKDDDDK
Sequence of entity 8 (D), FASTA
>3JC6_8 DNA replication complex GINS protein SLD5 (chains D)
MDINIDDILAELDKETTAVDSTKITQGSSSTTHRDANTIVGSSLDLNDKTQIYVSPQQDF
SDLMKSWKNERCSPELLPYPHQLMKRLLNRISMQSQLIENISMGFLDMQNASNANPPMPN
ESKLPLLCMETELERLKFVIRSYIRCRLSKIDKFSLYLRQLNEDENSLISLTDLLSKDEI
KYHDTHSLIWLKLVNDSILKYMPEELQAINDTEGSVNMIDEPDWNKFVFIHVNGPPDGKW
NEDPLLQENEFGKPCYTVTIPDLKEEVELTIGSIYVMRYEVIRDLLRDDKVALI
Sequence of entity 9 (B), FASTA
>3JC6_9 DNA replication complex GINS protein PSF2 (chains B)
MSLPAHLQQTFSPEEIQFIVENEPIKIFPRITTRQKIRGDDRGTGNHTRWQLITTDDKAL
NNMVAMRSTEVVLWIALLLKQQSKCSIVAPQWLTTKELDRKIQYEKTHPDRFSELPWNWL
VLARILFNKAKDDFHDPIHELRGKIQDLREIRQIKVLKGLKYLNESHLQLDNLSLLEINE
LRPFITEIMDKLREIHTASLTAGTENDEEEFNI
Sequence of entity 10 (A), FASTA
>3JC6_10 DNA replication complex GINS protein PSF1 (chains A)
MYGDLGNKLVLEAKRTKQLYARSNQDVNLPMYHEDIIRNILKEVSNLRKNTEYLKEQQQL
GMLDDKVAKCQYFVTLLCMERNKRCLLAYQRLRTDILDSMAWNNNGLDLMSSITFSQQDT
NNLSHQEQEYLKEYCDLITDLKSGDLVDIDLSGSLVPPSDVFIDVRVLKDAGEIQTEYGV
FNLIKDSQFFVRQSDVERLIQQGYLQKI
Sequence of entity 11 (C), FASTA
>3JC6_11 DNA replication complex GINS protein PSF3 (chains C)
MGYYDIDDVLADGTEFPCKFQYDIPGLGYLENNPGRPITKNTKLSLPLWLARILAIVGGD
EALVDEEPVPFVELLPPDMFSTKVMNAIKTDPVALDLHSINSHFFSLAIKWIMLFSEKEL
ANVVSELLLQRAQELNHHASSLSIDLNADSTGKNSANTNIATSTFLLKLEEMEKEIYKKS
HESYKDTKRWMFKK
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 1 |
Primary citation
Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Yuan, Z., Bai, L., Sun, J. et al. Nat Struct Mol Biol (2016) 23:217-224. DOI 10.1038/nsmb.3170 · PubMed
Other PDB entries of the same protein (UniProt P29469 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 7W8G 2.52 Å, Cryo-EM structure of MCM double hexamer
- 28VY 2.7 Å, sCMGE assembled on ARS1 DNA with Sld2 and RPA
- 8RIF 2.79 Å, Cryo-EM structure of the MCM double hexamer loaded onto dsDNA.
- 7V3V 2.9 Å, Cryo-EM structure of MCM double hexamer bound with DDK in State I
- 9TH8 2.9 Å, Cryo-EM structure of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA
- 7P30 3.0 Å, 3.0 A resolution structure of a DNA-loaded MCM double hexamer
- 8KG6 3.07 Å, Yeast replisome in state I
- 9RHL 3.1 Å, Phospho-DH bound by Sld3-MBD on ARS1 DNA
- 7PMK 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
- 7PMN 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II)
- 7PT6 3.2 Å, Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state III
- 7V3U 3.2 Å, Cryo-EM structure of MCM double hexamer with structured Mcm4-NSD
Browse structure collections
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