3OBU: Tsg101 UEV domain

Crystal structure of the Tsg101 UEV domain in complex with a HIV-1 PTAP peptide. Determined by X-ray diffraction at 1.6 Å resolution. Released 1 Dec 2010.

Method: X-ray diffraction
Resolution: 1.6 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,363
Mol. weight: 17.47 kDa
Released: 1 Dec 2010

Explore 3OBU in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3OBU contains 6 α-helices and 10 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	5-11	7
α-helix	18-31	14
β-strand	35-42	8	1
β-strand	44-63	17	1
β-strand	66-76	11	1
α-helix	84-85	2
β-strand	86-89	4	1
β-strand	95-97	3	2
β-strand	100	1	3
β-strand	103	1	3
β-strand	108	1	1
β-strand	109	1	3
α-helix	112-115	4
α-helix	124-137	14
β-strand	141-143	3	2

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	10-12	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Tumor susceptibility gene 101 protein	A	protein	146	Homo sapiens	Q99816 (AlphaFold model)
Gag polyprotein	B	protein	9		Q72497

Sequence of entity 1 (A), FASTA

>3OBU_1 Tumor susceptibility gene 101 protein (chains A)
GAMGSAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYGTGSRELMNLTGTI
PVPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKH
PQSDLLGLIQVMIVVFGDEPPVFSRP

Sequence of entity 2 (B), FASTA

>3OBU_2 Gag polyprotein (chains B)
PEPTAPPEE

Primary citation

Crystallographic and Functional Analysis of the ESCRT-I /HIV-1 Gag PTAP Interaction. Im, Y.J., Kuo, L., Ren, X. et al. Structure (2010) 18:1536-1547. DOI 10.1016/j.str.2010.08.010 · PubMed

Other PDB entries of the same protein (UniProt Q99816 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7NLC 1.4 Å, Crystallographic structure of human Tsg101 UEV domain in complex with a HEV ORF3 peptide
3OBQ 1.4 Å, Crystal Structure of the Tsg101 UEV domain in complex with a human HRS PSAP peptide
3OBS 1.5 Å, Crystal structure of Tsg101 UEV domain
3OBX 1.6 Å, Crystal structure of the Tsg101 UEV domain in complex with a HIV-1 Gag P7A mutant peptide
3P9G 1.8 Å, Crystal structure of the TSG101 UEV domain in complex with FA459 peptide
3P9H 1.8 Å, Crystal structure of the TSG101 UEV domain in complex with FA258 peptide
1S1Q 2.0 Å, TSG101(UEV) domain in complex with Ubiquitin
4YC1 2.0 Å, Structure of the human TSG101-UEV domain in the P321 space group
6VME 2.19 Å, Human ESCRT-I heterotetramer headpiece
4EJE 2.2 Å, Structure Of The Tsg101 UEV Domain In Complex With an Ebola PTAP late Domain Peptide
7ZLX 2.25 Å, Crystal Structure of the TSG101-UEV domain:space group P21
2F0R 2.26 Å, Crystallographic structure of human Tsg101 UEV domain

Browse structure collections

About this viewer

MolViewer shows 3OBU directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.