3OXQ: Ca2+/CaM-CaV1.2 pre-IQ/IQ domain complex

Crystal Structure of Ca2+/CaM-CaV1.2 pre-IQ/IQ domain complex. Determined by X-ray diffraction at 2.55 Å resolution. Released 3 Nov 2010.

Method: X-ray diffraction
Resolution: 2.55 Å
Organism: Homo sapiens
Chains: 6
Atoms: 5,036
Mol. weight: 86.23 kDa
Ligands: CA
Released: 3 Nov 2010

Explore 3OXQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3OXQ contains 36 α-helices and 12 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	26-27	2	1
α-helix	29-38	10
α-helix	45-55	11
β-strand	63-64	2	1
α-helix	65-76	12
α-helix	82-92	11
β-strand	99-100	2	2
α-helix	102-111	10
α-helix	118-128	11
β-strand	136-137	2	2
α-helix	138-146	9

Chain B: 8 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	6-17	12
β-strand	26-27	2	3
α-helix	29-38	10
α-helix	45-53	9
β-strand	63-64	2	3
α-helix	65-75	11
α-helix	83-90	8
α-helix	102-108	7
α-helix	118-128	11
α-helix	138-145	8

Chain C: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	26-27	2	4
α-helix	29-37	9
α-helix	45-55	11
β-strand	63-64	2	4
α-helix	65-77	13
α-helix	82-92	11
β-strand	100	1	5
α-helix	102-111	10
α-helix	118-128	11
β-strand	136	1	5
α-helix	138-146	9

Chain D: 8 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	6-17	12
β-strand	26-27	2	6
α-helix	29-38	10
α-helix	45-53	9
β-strand	63-64	2	6
α-helix	65-75	11
α-helix	83-90	8
α-helix	102-105	4
α-helix	118-128	11
α-helix	138-145	8

Chain E: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	1561-1598	38
α-helix	1615-1632	18

Chain F: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	1561-1600	40
α-helix	1615-1632	18

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A, B, C, D	protein	149	Homo sapiens	P0DP23 (AlphaFold model)
Voltage-dependent L-type calcium channel subunit alpha-1C	E, F	protein	78	Homo sapiens	Q13936 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>3OXQ_1 Calmodulin (chains A, B, C, D)
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (E, F), FASTA

>3OXQ_2 Voltage-dependent L-type calcium channel subunit alpha-1C (chains E, F)
GTLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFY
ATFLIQEYFRKFKKRKEQ

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	14

Primary citation

Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. Kim, E.Y., Rumpf, C.H., Van Petegem, F. et al. EMBO J (2010) 29:3924-3938. DOI 10.1038/emboj.2010.260 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
7BF1 1.24 Å, Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2…
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
4DJC 1.35 Å, 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
2W73 1.45 Å, High-resolution structure of the complex between calmodulin and a peptide from…
4LZX 1.5 Å, Complex of IQCG and Ca2+-free CaM
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93

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