3QYN: P63 DNA Binding Domain

Structure of p63 DNA Binding Domain in Complex with a 22 Base Pair A/T Rich Response Element Containing 2 Base Pair Spacer Between Half Sites. Determined by X-ray diffraction at 2.5 Å resolution. Released 6 Apr 2011.

Method
X-ray diffraction
Resolution
2.5 Å
Organism
Homo sapiens
Chains
6
Atoms
7,333
Mol. weight
104.49 kDa
Ligands
ZN
Released
6 Apr 2011

Explore 3QYN in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3QYN contains 17 α-helices and 50 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 14 β-strands

ElementResiduesLengthSheet
β-strand13211
α-helix134-1363
β-strand139-14132
β-strand153-15641
β-strand161-16441
β-strand170-17562
β-strand185-19281
β-strand20313
α-helix206-2105
β-strand22413
β-strand226-22942
β-strand235-23841
β-strand245-25061
α-helix253-2553
β-strand261-26772
β-strand282-28981
β-strand295-304101
α-helix309-3168
Chain B: 4 helices, 12 β-strands
ElementResiduesLengthSheet
β-strand13214
β-strand139-14135
β-strand153-15644
β-strand161-16444
β-strand169-17575
β-strand185-19284
α-helix201-2022
α-helix206-2105
β-strand226-22835
β-strand235-23844
β-strand245-25064
α-helix253-2553
β-strand261-26775
β-strand282-28984
β-strand295-305114
α-helix309-32012
Chain C: 5 helices, 12 β-strands
ElementResiduesLengthSheet
α-helix126-1283
β-strand13216
β-strand139-14137
β-strand153-15646
β-strand161-16446
β-strand169-17577
β-strand185-19286
α-helix201-2022
α-helix206-2105
β-strand226-22837
β-strand235-23846
β-strand245-25066
α-helix253-2553
β-strand261-26777
β-strand282-28986
β-strand295-305116
α-helix309-31911
Chain D: 4 helices, 12 β-strands
ElementResiduesLengthSheet
β-strand13218
β-strand139-14139
β-strand153-15648
β-strand161-16448
β-strand169-17579
β-strand185-19288
α-helix201-2022
α-helix206-2105
β-strand226-22839
β-strand235-23848
β-strand245-25068
α-helix253-2553
β-strand261-26779
β-strand282-28988
β-strand295-305118
α-helix309-31911

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Tumor protein 63A, B, C, Dprotein203Homo sapiensQ9H3D4 (AlphaFold model)
5'-d(*ap*ap*ap*cp*ap*tp*gp*tp*tp*tp*tp*ap*ap*ap*ap*cp*ap*tp*gp*tp*tp*t)-3'E, FDNA22
Sequence of entity 1 (A, B, C, D), FASTA
>3QYN_1 Tumor protein 63 (chains A, B, C, D)
GSHMASPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPP
PQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDP
ITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRC
FEARICACPGRDRKADEDSIRKQ
Sequence of entity 2 (E, F), FASTA
>3QYN_2 5'-D(*AP*AP*AP*CP*AP*TP*GP*TP*TP*TP*TP*AP*AP*AP*AP*CP*AP*TP*GP*TP*TP*T)-3' (chains E, F)
AAACATGTTTTAAAACATGTTT

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn4

Primary citation

Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements. Chen, C., Gorlatova, N., Kelman, Z. et al. Proc Natl Acad Sci U S A (2011) 108:6456-6461. DOI 10.1073/pnas.1013657108 · PubMed

Other PDB entries of the same protein (UniProt Q9H3D4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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