3SGP: Alpha-crystallin B chain

Amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L. Determined by X-ray diffraction at 1.4 Å resolution. Released 21 Mar 2012.

Method: X-ray diffraction
Resolution: 1.4 Å
Organism: Homo sapiens
Chains: 4
Atoms: 457
Mol. weight: 5.21 kDa
Ligands: MRD
Released: 21 Mar 2012

Explore 3SGP in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3SGP contains 0 α-helices and 4 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B, C and D: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	2-10	9	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Alpha-crystallin B chain	A, B, C, D	protein	11	Homo sapiens	P02511 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>3SGP_1 Alpha-crystallin B chain (chains A, B, C, D)
KLKVLGDVIEV

Ligands and cofactors

ID	Name	Formula	Copies
MRD	(4R)-2-methylpentane-2,4-diol	C6 H14 O2	1

Water and common crystallization additives (MPD) are not listed.

Primary citation

Atomic view of a toxic amyloid small oligomer. Laganowsky, A., Liu, C., Sawaya, M.R. et al. Science (2012) 335:1228-1231. DOI 10.1126/science.1213151 · PubMed

Other PDB entries of the same protein (UniProt P02511 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4M5S 1.37 Å, Human alphaB crystallin core domain in complex with C-terminal peptide
7ROJ 1.6 Å, Amyloid-related segment of alphaB-crystallin residues 90-100 with G95W mutation
3SGM 1.7 Å, Bromoderivative-2 of amyloid-related segment of alphaB-crystallin residues 90-100
3SGS 1.7 Å, Amyloid-related segment of alphaB-crystallin residues 95-100
2Y1Y 2.0 Å, Human alphaB crystallin ACD(residues 71-157)
4M5T 2.0 Å, Disulfide trapped human alphaB crystallin core domain in complex with C-terminal peptide
3SGR 2.17 Å, Tandem repeat of amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L
2Y1Z 2.5 Å, Human alphaB Crystallin ACD R120G
3SGO 2.56 Å, Amyloid-related segment of alphaB-crystallin residues 90-100
2WJ7 2.63 Å, human alphaB crystallin
5VVV 2.8 Å, Structural Investigations of the Substrate Specificity of Human O-GlcNAcase
3SGN 2.81 Å, Bromoderivative-8 of amyloid-related segment of alphaB-crystallin residues 90-100

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