7ROJ: Alpha-crystallin B chain peptide

Amyloid-related segment of alphaB-crystallin residues 90-100 with G95W mutation. Determined by X-ray diffraction at 1.6 Å resolution. Released 12 Jan 2022.

Method: X-ray diffraction
Resolution: 1.6 Å
Organism: Homo sapiens
Chains: 12
Atoms: 1,212
Mol. weight: 16.53 kDa
Ligands: TFA
Released: 12 Jan 2022

Explore 7ROJ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7ROJ contains 0 α-helices and 12 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, B, C, D, E, F, G, H, I and J: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	2-10	9	1

Chain K: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	2-9	8	2

Chain L: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	3-10	8	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Alpha-crystallin B chain peptide	A, B, C, D, E, F, G, H, I, J, K, L	protein	11	Homo sapiens	P02511 (AlphaFold model)

Sequence of entity 1 (A, B, C, D, E, F, G, H, I, J, K, L), FASTA

>7ROJ_1 Alpha-crystallin B chain peptide (chains A, B, C, D, E, F, G, H, I, J, K, L)
KVKVLWDVIEV

Ligands and cofactors

ID	Name	Formula	Copies
TFA	trifluoroacetic acid	C2 H F3 O2	4

Water and common crystallization additives (GOL, NA) are not listed.

Primary citation

Atomic view of an amyloid dodecamer exhibiting selective cellular toxic vulnerability in acute brain slices. Gray, A.L.H., Sawaya, M.R., Acharyya, D. et al. Protein Sci (2022) 31:716-727. DOI 10.1002/pro.4268 · PubMed

Other PDB entries of the same protein (UniProt P02511 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4M5S 1.37 Å, Human alphaB crystallin core domain in complex with C-terminal peptide
3SGP 1.4 Å, Amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L
3SGM 1.7 Å, Bromoderivative-2 of amyloid-related segment of alphaB-crystallin residues 90-100
3SGS 1.7 Å, Amyloid-related segment of alphaB-crystallin residues 95-100
2Y1Y 2.0 Å, Human alphaB crystallin ACD(residues 71-157)
4M5T 2.0 Å, Disulfide trapped human alphaB crystallin core domain in complex with C-terminal peptide
3SGR 2.17 Å, Tandem repeat of amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L
2Y1Z 2.5 Å, Human alphaB Crystallin ACD R120G
3SGO 2.56 Å, Amyloid-related segment of alphaB-crystallin residues 90-100
2WJ7 2.63 Å, human alphaB crystallin
5VVV 2.8 Å, Structural Investigations of the Substrate Specificity of Human O-GlcNAcase
3SGN 2.81 Å, Bromoderivative-8 of amyloid-related segment of alphaB-crystallin residues 90-100

Browse structure collections

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