3US0: P63 DNA Binding Domain

Structure of p63 DNA Binding Domain in Complex with a 22 Base Pair A/T Rich Response Element Containing a Two Base Pair "AT" Spacer Between Half Sites. Determined by X-ray diffraction at 2.5 Å resolution. Released 1 Feb 2012.

Method
X-ray diffraction
Resolution
2.5 Å
Organism
Homo sapiens
Chains
6
Atoms
7,279
Mol. weight
104.49 kDa
Ligands
ZN
Released
1 Feb 2012

Explore 3US0 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3US0 contains 17 α-helices and 48 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 12 β-strands

ElementResiduesLengthSheet
β-strand13211
α-helix134-1363
β-strand139-14132
β-strand153-15641
β-strand161-16441
β-strand169-17572
β-strand185-19281
α-helix206-2105
β-strand226-22942
β-strand235-23841
β-strand245-25061
α-helix253-2553
β-strand261-26772
β-strand282-28981
β-strand295-305111
α-helix309-3168
Chain B: 4 helices, 12 β-strands
ElementResiduesLengthSheet
α-helix126-1283
β-strand13213
β-strand139-14134
β-strand153-15643
β-strand161-16443
β-strand169-17574
β-strand185-19283
α-helix201-2022
α-helix206-2105
β-strand226-22834
β-strand235-23843
β-strand245-25063
β-strand261-26774
β-strand282-28983
β-strand295-305113
α-helix309-31911
Chain C: 4 helices, 12 β-strands
ElementResiduesLengthSheet
β-strand13215
β-strand139-14136
β-strand153-15645
β-strand161-16445
β-strand169-17576
β-strand185-19285
α-helix201-2022
α-helix206-2105
β-strand226-22836
β-strand235-23845
β-strand245-25065
α-helix253-2553
β-strand261-26776
β-strand282-28985
β-strand295-304105
α-helix309-31810
Chain D: 5 helices, 12 β-strands
ElementResiduesLengthSheet
α-helix126-1283
β-strand13217
β-strand139-14138
β-strand153-15647
β-strand161-16557
β-strand169-17578
β-strand185-19287
α-helix201-2022
α-helix206-2105
β-strand226-22838
β-strand235-23847
β-strand245-25067
α-helix253-2553
β-strand261-26778
β-strand282-28987
β-strand295-306127
α-helix309-32012

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Tumor protein 63A, B, C, Dprotein203Homo sapiensQ9H3D4 (AlphaFold model)
5'-d(*ap*ap*ap*cp*ap*tp*gp*tp*tp*tp*ap*tp*ap*ap*ap*cp*ap*tp*gp*tp*tp*t)-3'E, FDNA22
Sequence of entity 1 (A, B, C, D), FASTA
>3US0_1 Tumor protein 63 (chains A, B, C, D)
GSHMASPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPP
PQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDP
ITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRC
FEARICACPGRDRKADEDSIRKQ
Sequence of entity 2 (E, F), FASTA
>3US0_2 5'-D(*AP*AP*AP*CP*AP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*TP*GP*TP*TP*T)-3' (chains E, F)
AAACATGTTTATAAACATGTTT

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn4

Primary citation

Pliable DNA Conformation of Response Elements Bound to Transcription Factor p63. Chen, C., Gorlatova, N., Herzberg, O. J Biol Chem (2012) 287:7477-7486. DOI 10.1074/jbc.M111.315820 · PubMed

Other PDB entries of the same protein (UniProt Q9H3D4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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