3WTZ: ETS-1 DNA binding and autoinhibitory domains

Crystal structure of ETS-1 DNA binding and autoinhibitory domains (276-441). Determined by X-ray diffraction at 2.61 Å resolution. Released 20 Aug 2014.

Method: X-ray diffraction
Resolution: 2.61 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,245
Mol. weight: 38.43 kDa
Released: 20 Aug 2014

Explore 3WTZ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3WTZ contains 19 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	304-309	6
α-helix	317-319	3
α-helix	323-330	8
α-helix	337-345	9
α-helix	348-350	3
β-strand	354-356	3	1
β-strand	362-365	4	1
α-helix	368-379	12
α-helix	386-398	13
β-strand	402-404	3	1
α-helix	405	1
β-strand	411-414	4	1
α-helix	418-422	5
α-helix	426-432	7

Chain B: 9 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	304-314	11
α-helix	323-330	8
α-helix	337-345	9
α-helix	348-350	3
β-strand	354-356	3	2
β-strand	362-365	4	2
α-helix	368-376	9
α-helix	387-398	12
β-strand	402-404	3	2
α-helix	405	1
β-strand	411-414	4	2
α-helix	418-422	5
α-helix	426-432	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Protein C-ets-1	A, B	protein	166	Homo sapiens	P14921 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>3WTZ_1 Protein C-ets-1 (chains A, B)
SLQRVPSYDSFDSEDYPAALPNHKPKGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPI
QLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRY
YYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVKPDADE

Primary citation

A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions. Shiina, M., Hamada, K., Inoue-Bungo, T. et al. J Mol Biol (2015) 427:1655-1669. DOI 10.1016/j.jmb.2014.07.020 · PubMed

Other PDB entries of the same protein (UniProt P14921 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1GVJ 1.53 Å, Ets-1 DNA binding and autoinhibitory domains
4LG0 2.19 Å, Structure of a ternary FOXO1-ETS1 DNA complex
4L18 2.3 Å, Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 3)
3WTS 2.35 Å, Crystal structure of the complex comprised of ETS1, RUNX1, CBFBETA, and the tcralpha…
3WTT 2.35 Å, Crystal structure of the complex comprised of phosphorylated ETS1, RUNX1, CBFBETA, and…
3WU1 2.4 Å, Crystal structure of the ETS1-RUNX1-DNA ternary complex
4L0Y 2.5 Å, Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 1)
2NNY 2.58 Å, Crystal structure of the Ets1 dimer DNA complex.
3WU0 2.6 Å, Crystal structure of phosphorylated ETS-1 DNA binding and autoinhibitory domains (276-441)
3WTU 2.7 Å, Crystal structure of the complex comprised of ETS1 (V170A), RUNX1, CBFBETA, and the…
3WTV 2.7 Å, Crystal structure of the complex comprised of ETS1(V170G), RUNX1, CBFBETA, and the…
3WTY 2.7 Å, Crystal structure of the complex comprised of ETS1(G333P), RUNX1, CBFBETA, and the…

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