4DJC: Calmodulin

1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex. Determined by X-ray diffraction at 1.35 Å resolution. Released 22 Feb 2012.

Method: X-ray diffraction
Resolution: 1.35 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,547
Mol. weight: 21.95 kDa
Ligands: IPA, CA
Released: 22 Feb 2012

Explore 4DJC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4DJC contains 9 α-helices and 4 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	2-4	3
α-helix	7-20	14
β-strand	27-28	2	1
α-helix	30-39	10
α-helix	46-56	11
β-strand	64-65	2	1
α-helix	66-93	28
β-strand	100-101	2	2
α-helix	103-112	10
α-helix	119-129	11
β-strand	137-138	2	2
α-helix	139-146	8

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	1490-1500	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A	protein	152	Homo sapiens	P0DP23 (AlphaFold model)
Sodium channel protein type 5 subunit alpha	B	protein	35	Homo sapiens	Q14524 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4DJC_1 Calmodulin (chains A)
SNAMADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVD
ADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKL
TDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B), FASTA

>4DJC_2 Sodium channel protein type 5 subunit alpha (chains B)
SNAQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIF

Ligands and cofactors

ID	Name	Formula	Copies
IPA	Isopropyl alcohol	C3 H8 O	9
CA	Calcium ion	Ca	4

Primary citation

Crystallographic basis for calcium regulation of sodium channels. Sarhan, M.F., Tung, C.C., Van Petegem, F. et al. Proc Natl Acad Sci U S A (2012) 109:3558-3563. DOI 10.1073/pnas.1114748109 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
7BF1 1.24 Å, Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2…
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
2W73 1.45 Å, High-resolution structure of the complex between calmodulin and a peptide from…
4LZX 1.5 Å, Complex of IQCG and Ca2+-free CaM
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93
6DAD 1.65 Å, 1.65 Angstrom crystal structure of the N97I Ca/CaM:CaV1.2 IQ domain complex

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