4DRA: MHF complex

Crystal structure of MHF complex. Determined by X-ray diffraction at 2.41 Å resolution. Released 16 May 2012.

Method: X-ray diffraction
Resolution: 2.41 Å
Organism: Homo sapiens
Chains: 8
Atoms: 5,387
Mol. weight: 90.33 kDa
Released: 16 May 2012

Explore 4DRA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4DRA contains 30 α-helices and 16 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	15-38	24
β-strand	42	1	1
α-helix	44-71	28
β-strand	76-77	2	2
α-helix	79-85	7
α-helix	90-103	14

Chain B: 6 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	15-37	23
α-helix	41	1
β-strand	42	1	3
α-helix	43	1
α-helix	44-71	28
β-strand	76-77	2	4
α-helix	79-85	7
α-helix	90-106	17

Chain C: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	8-37	30
β-strand	42	1	5
α-helix	44-71	28
β-strand	76-77	2	6
α-helix	79-85	7
α-helix	90-103	14

Chain D: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	12-37	26
β-strand	42	1	7
α-helix	44-71	28
β-strand	76-77	2	8
α-helix	79-84	6
α-helix	90-101	12

Chains E, G and H: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	12-20	9
β-strand	29-30	2	2
α-helix	32-59	28
β-strand	65	1	1
α-helix	67-80	14

Chain F: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	12-20	9
β-strand	29-30	2	4
α-helix	32-60	29
β-strand	65	1	3
α-helix	67-80	14

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Centromere protein S	A, B, C, D	protein	113	Homo sapiens	Q8N2Z9 (AlphaFold model)
Centromere protein X	E, F, G, H	protein	84	Homo sapiens	A8MT69 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>4DRA_1 Centromere protein S (chains A, B, C, D)
HHHHHHMEEEAETEEQQRFSYQQRLKAAVHYTVGCLCEEVALDKEMQFSKQTIAAISELT
FRQCENFAKDLEMFARHAKRTTINTEDVKLLARRSNSLLKYITDKSEEIAQIN

Sequence of entity 2 (E, F, G, H), FASTA

>4DRA_2 Centromere protein X (chains E, F, G, H)
GSHMEGAGAGSGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQA
QAEDALRVDVDQLEKVLPQLLLDF

Primary citation

The structure of the FANCM-MHF complex reveals physical features for functional assembly. Tao, Y., Jin, C., Li, X. et al. Nat Commun (2012) 3:782-782. DOI 10.1038/ncomms1779 · PubMed

Other PDB entries of the same protein (UniProt Q8N2Z9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4NE3 1.8 Å, Human MHF1-MHF2 complex
4E45 2.0 Å, Crystal structure of the hMHF1/hMHF2 Histone-Fold Tetramer in Complex with Fanconi…
4E44 2.1 Å, Crystal structure of the hMHF1/hMHF2 Histone-Fold Tetramer
4NE6 2.1 Å, Human MHF1-MHF2 complex
4NE5 2.5 Å, Human MHF1-MHF2 complex
4DRB 2.63 Å, The crystal structure of FANCM bound MHF complex
28OP 2.7 Å, Structure of the human inner kinetochore CCAN and CENP-C bound to DNA
7R5S 2.83 Å, Structure of the human CCAN bound to alpha satellite DNA
7XHO 3.29 Å, Structure of human inner kinetochore CCAN complex
9TAW 3.54 Å, Structure of the human inner kinetochore CCAN bound to DNA
7XHN 3.71 Å, Structure of human inner kinetochore CCAN-DNA complex
9TAX 4.5 Å, Structure of the human inner kinetochore CCAN bound to a mono-CENP-A nucleosome

Browse structure collections

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